PMID- 38077803
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231211
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 14
IP  - 11
DP  - 2023 Nov 15
TI  - Mechanisms of action of natural products on type 2 diabetes.
PG  - 1603-1620
LID - 10.4239/wjd.v14.i11.1603 [doi]
AB  - Over the past several decades, type 2 diabetes mellitus (T2DM) has been 
      considered a global public health concern. Currently, various therapeutic 
      modalities are available for T2DM management, including dietary modifications, 
      moderate exercise, and use of hypoglycemic agents and lipid-lowering medications. 
      Although the curative effect of most drugs on T2DM is significant, they also 
      exert some adverse side effects. Biologically active substances found in natural 
      medicines are important for T2DM treatment. Several recent studies have reported 
      that active ingredients derived from traditional medicines or foods exert a 
      therapeutic effect on T2DM. This review compiled important articles regarding the 
      therapeutic effects of natural products and their active ingredients on islet beta 
      cell function, adipose tissue inflammation, and insulin resistance. Additionally, 
      this review provided an in-depth understanding of the multiple regulatory effects 
      on different targets and signaling pathways of natural medicines in the treatment 
      of T2DM as well as a theoretical basis for clinical effective application.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Wang, Tao
AU  - Wang T
AD  - Clinical Molecular Immunology Center, Yangtze University, Jingzhou 434023, Hubei 
      Province, China.
FAU - Wang, Yang-Yang
AU  - Wang YY
AD  - Clinical Molecular Immunology Center, Yangtze University, Jingzhou 434023, Hubei 
      Province, China.
FAU - Shi, Meng-Yue
AU  - Shi MY
AD  - Clinical Molecular Immunology Center, Yangtze University, Jingzhou 434023, Hubei 
      Province, China.
FAU - Liu, Lian
AU  - Liu L
AD  - Department of Pharmacology, Yangtze University, Jingzhou 434023, Hubei Province, 
      China. liulian@yangtzeu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10704200
OTO - NOTNLM
OT  - Adipose tissue inflammation
OT  - Insulin resistance
OT  - Natural product
OT  - Type 2 diabetes
OT  - beta cell
COIS- Conflict-of-interest statement: The authors declare having no conflicts of 
      interest.
EDAT- 2023/12/11 12:43
MHDA- 2023/12/11 12:44
PMCR- 2023/11/15
CRDT- 2023/12/11 06:35
PHST- 2023/08/31 00:00 [received]
PHST- 2023/09/14 00:00 [revised]
PHST- 2023/10/23 00:00 [accepted]
PHST- 2023/12/11 12:44 [medline]
PHST- 2023/12/11 12:43 [pubmed]
PHST- 2023/12/11 06:35 [entrez]
PHST- 2023/11/15 00:00 [pmc-release]
AID - 10.4239/wjd.v14.i11.1603 [doi]
PST - ppublish
SO  - World J Diabetes. 2023 Nov 15;14(11):1603-1620. doi: 10.4239/wjd.v14.i11.1603.