PMID- 38078712
OWN - NLM
STAT- MEDLINE
DCOM- 20240207
LR  - 20240207
IS  - 1827-1839 (Electronic)
IS  - 0392-9590 (Linking)
VI  - 42
IP  - 6
DP  - 2023 Dec
TI  - Circumferential degree of tibial artery calcification is associated with 
      infrapopliteal endovascular revascularization outcomes in patients with chronic 
      limb-threatening ischemia.
PG  - 528-536
LID - 10.23736/S0392-9590.23.05130-1 [doi]
AB  - BACKGROUND: Tibial artery calcification (TAC) is correlated with an increased 
      risk of amputation and mortality in patients with chronic limb-threatening 
      ischemia (CLTI). The association between calcification characteristics and 
      adverse limb events of CLTI. However, it has not been assessed. This study aims 
      to assess the relationship between the characteristics of TAC based on computed 
      tomography angiography (CTA) scans and postoperative outcomes in patients with 
      CLTI undergoing infrapopliteal endovascular therapy. METHODS: This was a 
      retrospective study of patients who underwent infrapopliteal endovascular 
      revascularization for CLTI and had a preoperative CTA scan. Based on CTA, TAC was 
      divided into the following categories: annularity, thickness, continuity and 
      severity. Cox regression models using generalized estimating equations were 
      performed to assess the relationship between calcification characteristics and 
      postoperative outcomes. The outcomes evaluated were the occurrence of all cause 
      mortality (ACM) and unplanned amputation. RESULTS: Among the 148 patients 
      undergoing endovascular, there were 50 (33.8%) patients died and 26 (17.6%) 
      patients underwent unplanned amputation. Annular calcification was more common in 
      the ACM group than in the non-ACM group. No significant differences were found 
      between the two groups with regard to the probability of calcification in the 
      thickness and the continuity (P>0.05). Patients in the unplanned amputation group 
      had significantly annular, thin and continuity calcifications (P<0.05) than those 
      in the non-unplanned amputation group. The presence of annular calcification was 
      an independent predictor of ACM (hazard ratio (HR), 3.186; 95% confidence 
      interval (CI), 1.781-5.702; P<0.001) and unplanned amputation (HR, 3.739; 95% CI, 
      1.707-8.191; P<0.05). CONCLUSIONS: Among patients with CLTI, the occurrence of 
      annular calcification in the tibial artery are related to a greater chance of ACM 
      and unplanned amputation in the postoperative period. The circumferential degree 
      of TAC of the operated limb can be considered as a marker of clinical prognosis 
      in this group of patients.
FAU - Dong, Yue
AU  - Dong Y
AD  - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Liu, Yuankang
AU  - Liu Y
AD  - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Liao, Hongli
AU  - Liao H
AD  - Department of Radiology, Central Hospital of Wuhan, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Cheng, Panpan
AU  - Cheng P
AD  - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Liu, Xiaoqi
AU  - Liu X
AD  - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Huang, Wei
AU  - Huang W
AD  - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Cai, Shuang
AU  - Cai S
AD  - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Jiang, Cuiping
AU  - Jiang C
AD  - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Liu, Shuhua
AU  - Liu S
AD  - Department of Burns, Tongren Hospital of Wuhan University, Wuhan, China.
FAU - Xu, Xiangyang
AU  - Xu X
AD  - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Radiology, Liyuan Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China - 740202975@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20231211
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
SB  - IM
MH  - Humans
MH  - Chronic Limb-Threatening Ischemia
MH  - Tibial Arteries/diagnostic imaging/surgery
MH  - *Endovascular Procedures/methods
MH  - Risk Factors
MH  - Retrospective Studies
MH  - *Peripheral Arterial Disease/diagnostic imaging/surgery
MH  - Treatment Outcome
MH  - Ischemia/diagnostic imaging/surgery
MH  - Limb Salvage/adverse effects/methods
MH  - Chronic Disease
EDAT- 2023/12/11 12:42
MHDA- 2024/02/07 06:42
CRDT- 2023/12/11 09:01
PHST- 2024/02/07 06:42 [medline]
PHST- 2023/12/11 12:42 [pubmed]
PHST- 2023/12/11 09:01 [entrez]
AID - S0392-9590.23.05130-1 [pii]
AID - 10.23736/S0392-9590.23.05130-1 [doi]
PST - ppublish
SO  - Int Angiol. 2023 Dec;42(6):528-536. doi: 10.23736/S0392-9590.23.05130-1. Epub 
      2023 Dec 11.