PMID- 38079181
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 64
IP  - 11
DP  - 2023 Nov
TI  - Adjunctive brivaracetam and sustained seizure frequency reduction in very active 
      focal epilepsy.
PG  - 2922-2933
LID - 10.1111/epi.17740 [doi]
AB  - OBJECTIVE: This study aimed to explore the effectiveness of brivaracetam (BRV) 
      according to baseline seizure frequency and past treatment history in subjects 
      with focal epilepsy who were included in the Brivaracetam Add-On First Italian 
      Network Study (BRIVAFIRST). METHODS: BRIVAFIRST was a 12-month retrospective, 
      multicenter study including adults prescribed adjunctive BRV. Study outcomes 
      included sustained seizure response (SSR), sustained seizure freedom (SSF), and 
      the rates of treatment discontinuation and adverse events (AEs). Baseline seizure 
      frequency was stratified as <5, 5-20, and >20 seizures per month, and the number 
      of prior antiseizure medications (ASMs) as <5 and >/=6. RESULTS: A total of 994 
      participants were included. During the 1-year study period, SSR was reached by 
      45.8%, 39.3%, and 22.6% of subjects with a baseline frequency of <5, 5-20, and 
      >20 seizures per month (p < .001); the corresponding figures for the SSF were 
      23.4%, 9.8%, and 2.8% (p < .001). SSR was reached by 51.2% and 26.5% participants 
      with a history of 1-5 and >/=6 ASMs (p < .001); the corresponding rates of SSF were 
      24.7% and 4.5% (p < .001). Treatment discontinuation due to lack of efficacy was 
      more common in participants with >20 seizures compared to those with <5 seizures 
      per month (25.8% vs. 9.3%, p < .001), and in participants with history of >/=6 
      prior ASMs compared to those with history of 1-5 ASMs (19.6% vs. 12.2%, 
      p = .002). There were no differences in the rates of BRV withdrawal due to AEs 
      and the rates of AEs across the groups of participants defined according to the 
      number of seizures at baseline and the number of prior ASMs. SIGNIFICANCE: The 
      baseline seizure frequency and the number of previous ASMs were predictors of 
      sustained seizure frequency reduction with adjunctive BRV in subjects with focal 
      epilepsy.
CI  - (c) 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of 
      International League Against Epilepsy.
FAU - Lattanzi, Simona
AU  - Lattanzi S
AUID- ORCID: 0000-0001-8748-0083
AD  - Neurological Clinic, Department of Experimental and Clinical Medicine, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Canafoglia, Laura
AU  - Canafoglia L
AUID- ORCID: 0000-0002-5385-761X
AD  - Department of Epileptology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 
      Milan, Italy.
FAU - Canevini, Maria Paola
AU  - Canevini MP
AD  - Epilepsy Center, Child Neuropsychiatry Unit, AAST Santi Paolo Carlo, Milan, 
      Italy.
AD  - Department of Health Sciences, Universita degli Studi, Milan, Italy.
FAU - Casciato, Sara
AU  - Casciato S
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Cerulli Irelli, Emanuele
AU  - Cerulli Irelli E
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Chiesa, Valentina
AU  - Chiesa V
AD  - Epilepsy Center, Child Neuropsychiatry Unit, AAST Santi Paolo Carlo, Milan, 
      Italy.
FAU - Dainese, Filippo
AU  - Dainese F
AD  - Epilepsy Center, Neurology Unit, Venice, Italy.
FAU - De Maria, Giovanni
AU  - De Maria G
AD  - Clinical Neurophysiology Unit, Epilepsy Center, Spedali Civili, Brescia, Italy.
FAU - Didato, Giuseppe
AU  - Didato G
AUID- ORCID: 0000-0002-4812-6310
AD  - Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
FAU - Di Gennaro, Giancarlo
AU  - Di Gennaro G
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Falcicchio, Giovanni
AU  - Falcicchio G
AUID- ORCID: 0000-0003-0745-5246
AD  - Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 
      Hospital of Bari A. Moro, Bari, Italy.
FAU - Fanella, Martina
AU  - Fanella M
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Ferlazzo, Edoardo
AU  - Ferlazzo E
AD  - Department of Medical and Surgical Sciences, Magna Graecia University of 
      Catanzaro, Catanzaro, Italy.
FAU - Gangitano, Massimo
AU  - Gangitano M
AD  - Department of Biomedicine, Neuroscience, and Advanced Diagnostics, University of 
      Palermo, Palermo, Italy.
FAU - La Neve, Angela
AU  - La Neve A
AD  - Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 
      Hospital of Bari A. Moro, Bari, Italy.
FAU - Mecarelli, Oriano
AU  - Mecarelli O
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Montalenti, Elisa
AU  - Montalenti E
AD  - Epilepsy Center, AOU Citta della Salute e della Scienza di Torino, Turin, Italy.
FAU - Morano, Alessandra
AU  - Morano A
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Piazza, Federico
AU  - Piazza F
AD  - Rita Levi Montalcini Department of Neurosciences, University of Turin, Turin, 
      Italy.
FAU - Pizzanelli, Chiara
AU  - Pizzanelli C
AUID- ORCID: 0000-0001-5044-8944
AD  - Department of Translational Research on New Technologies in Medicine and Surgery, 
      University of Pisa, Pisa, Italy.
AD  - Neurology Unit, Pisa University Hospital, Pisa, Italy.
FAU - Pulitano, Patrizia
AU  - Pulitano P
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Ranzato, Federica
AU  - Ranzato F
AD  - Epilepsy Center, UOC Neurology, AULSS 8 Vicenza, Vicenza, Italy.
FAU - Rosati, Eleonora
AU  - Rosati E
AD  - Department of Neurofarba, University of Florence, Florence, Italy.
FAU - Tassi, Laura
AU  - Tassi L
AD  - C. Munari Epilepsy Surgery Center, Niguarda Hospital, Milan, Italy.
FAU - Di Bonaventura, Carlo
AU  - Di Bonaventura C
AUID- ORCID: 0000-0003-1890-5409
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
CN  - BRIVAFIRST (Brivaracetam Add-On First Italian Network Study) Group Membership
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20230909
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - U863JGG2IA (brivaracetam)
RN  - 0 (Anticonvulsants)
RN  - 0 (Pyrrolidinones)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Anticonvulsants/therapeutic use
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Drug Therapy, Combination
MH  - Seizures/drug therapy/chemically induced
MH  - *Epilepsies, Partial/drug therapy
MH  - Pyrrolidinones/therapeutic use
OTO - NOTNLM
OT  - antiseizure medication
OT  - brivaracetam
OT  - epilepsy
OT  - focal seizures
FIR - Alicino, Angela
IR  - Alicino A
FIR - Ascoli, Michele
IR  - Ascoli M
FIR - Assenza, Giovanni
IR  - Assenza G
FIR - Avorio, Federica
IR  - Avorio F
FIR - Badioni, Valeria
IR  - Badioni V
FIR - Banfi, Paola
IR  - Banfi P
FIR - Bartolini, Emanuele
IR  - Bartolini E
FIR - Basili, Luca Manfredi
IR  - Basili LM
FIR - Belcastro, Vincenzo
IR  - Belcastro V
FIR - Beretta, Simone
IR  - Beretta S
FIR - Berto, Irene
IR  - Berto I
FIR - Biggi, Martina
IR  - Biggi M
FIR - Billo, Giuseppe
IR  - Billo G
FIR - Boero, Giovanni
IR  - Boero G
FIR - Bonanni, Paolo
IR  - Bonanni P
FIR - Bongiorno, Jole
IR  - Bongiorno J
FIR - Brigo, Francesco
IR  - Brigo F
FIR - Caggia, Emanuele
IR  - Caggia E
FIR - Cagnetti, Claudia
IR  - Cagnetti C
FIR - Calvello, Carmen
IR  - Calvello C
FIR - Cesnik, Edward
IR  - Cesnik E
FIR - Chianale, Gigliola
IR  - Chianale G
FIR - Ciampanelli, Domenico
IR  - Ciampanelli D
FIR - Ciuffini, Roberta
IR  - Ciuffini R
FIR - Cocito, Dario
IR  - Cocito D
FIR - Colella, Donato
IR  - Colella D
FIR - Contento, Margherita
IR  - Contento M
FIR - Costa, Cinzia
IR  - Costa C
FIR - Cumbo, Eduardo
IR  - Cumbo E
FIR - D'Aniello, Alfredo
IR  - D'Aniello A
FIR - Deleo, Francesco
IR  - Deleo F
FIR - DiFrancesco, Jacopo C
IR  - DiFrancesco JC
FIR - Di Giacomo, Roberta
IR  - Di Giacomo R
FIR - Di Liberto, Alessandra
IR  - Di Liberto A
FIR - Domina, Elisabetta
IR  - Domina E
FIR - Dono, Fedele
IR  - Dono F
FIR - Durante, Vania
IR  - Durante V
FIR - Elia, Maurizio
IR  - Elia M
FIR - Estraneo, Anna
IR  - Estraneo A
FIR - Evangelista, Giacomo
IR  - Evangelista G
FIR - Faedda, Maria Teresa
IR  - Faedda MT
FIR - Failli, Ylenia
IR  - Failli Y
FIR - Fallica, Elisa
IR  - Fallica E
FIR - Fattouch, Jinane
IR  - Fattouch J
FIR - Ferrari, Alessandra
IR  - Ferrari A
FIR - Ferreri, Florinda
IR  - Ferreri F
FIR - Fisco, Giacomo
IR  - Fisco G
FIR - Fonti, Davide
IR  - Fonti D
FIR - Fortunato, Francesco
IR  - Fortunato F
FIR - Foschi, Nicoletta
IR  - Foschi N
FIR - Francavilla, Teresa
IR  - Francavilla T
FIR - Galli, Rosita
IR  - Galli R
FIR - Gazzina, Stefano
IR  - Gazzina S
FIR - Giallonardo, Anna Teresa
IR  - Giallonardo AT
FIR - Giorgi, Filippo Sean
IR  - Giorgi FS
FIR - Giuliano, Loretta
IR  - Giuliano L
FIR - Habetswallner, Francesco
IR  - Habetswallner F
FIR - Izzi, Francesca
IR  - Izzi F
FIR - Kassabian, Benedetta
IR  - Kassabian B
FIR - Labate, Angelo
IR  - Labate A
FIR - Luisi, Concetta
IR  - Luisi C
FIR - Magliani, Matteo
IR  - Magliani M
FIR - Maira, Giulia
IR  - Maira G
FIR - Mari, Luisa
IR  - Mari L
FIR - Marino, Daniela
IR  - Marino D
FIR - Mascia, Addolorata
IR  - Mascia A
FIR - Mazzeo, Alessandra
IR  - Mazzeo A
FIR - Meletti, Stefano
IR  - Meletti S
FIR - Milano, Chiara
IR  - Milano C
FIR - Nilo, Annacarmen
IR  - Nilo A
FIR - Orlando, Biagio
IR  - Orlando B
FIR - Paladin, Francesco
IR  - Paladin F
FIR - Pascarella, Maria Grazia
IR  - Pascarella MG
FIR - Pastori, Chiara
IR  - Pastori C
FIR - Pauletto, Giada
IR  - Pauletto G
FIR - Peretti, Alessia
IR  - Peretti A
FIR - Perri, Gabriella
IR  - Perri G
FIR - Pezzella, Marianna
IR  - Pezzella M
FIR - Piccioli, Marta
IR  - Piccioli M
FIR - Pignatta, Pietro
IR  - Pignatta P
FIR - Pilolli, Nicola
IR  - Pilolli N
FIR - Pisani, Francesco
IR  - Pisani F
FIR - Pisani, Laura Rosa
IR  - Pisani LR
FIR - Placidi, Fabio
IR  - Placidi F
FIR - Pollicino, Patrizia
IR  - Pollicino P
FIR - Porcella, Vittoria
IR  - Porcella V
FIR - Pradella, Silvia
IR  - Pradella S
FIR - Puligheddu, Monica
IR  - Puligheddu M
FIR - Quadri, Stefano
IR  - Quadri S
FIR - Quarato, Pier Paolo
IR  - Quarato PP
FIR - Quintas, Rui
IR  - Quintas R
FIR - Renna, Rosaria
IR  - Renna R
FIR - Rizzo, Giada Ricciardo
IR  - Rizzo GR
FIR - Rum, Adriana
IR  - Rum A
FIR - Salamone, Enrico Michele
IR  - Salamone EM
FIR - Savastano, Ersilia
IR  - Savastano E
FIR - Sessa, Maria
IR  - Sessa M
FIR - Stokelj, David
IR  - Stokelj D
FIR - Tartara, Elena
IR  - Tartara E
FIR - Tombini, Mario
IR  - Tombini M
FIR - Tumminelli, Gemma
IR  - Tumminelli G
FIR - Vaudano, Anna Elisabetta
IR  - Vaudano AE
FIR - Ventura, Maria
IR  - Ventura M
FIR - Vigano, Ilaria
IR  - Vigano I
FIR - Viglietta, Emanuela
IR  - Viglietta E
FIR - Vignoli, Aglaia
IR  - Vignoli A
FIR - Villani, Flavio
IR  - Villani F
FIR - Zambrelli, Elena
IR  - Zambrelli E
FIR - Zummo, Lelia
IR  - Zummo L
EDAT- 2023/12/11 12:42
MHDA- 2023/12/17 13:19
CRDT- 2023/12/11 11:34
PHST- 2023/08/03 00:00 [revised]
PHST- 2023/06/10 00:00 [received]
PHST- 2023/08/03 00:00 [accepted]
PHST- 2023/12/17 13:19 [medline]
PHST- 2023/12/11 12:42 [pubmed]
PHST- 2023/12/11 11:34 [entrez]
AID - 10.1111/epi.17740 [doi]
PST - ppublish
SO  - Epilepsia. 2023 Nov;64(11):2922-2933. doi: 10.1111/epi.17740. Epub 2023 Sep 9.