PMID- 38079259
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240226
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 47
IP  - 3
DP  - 2024 Mar 1
TI  - Association of Body Weight Time in Target Range With the Risk of Kidney Outcomes 
      in Patients With Overweight/Obesity and Type 2 Diabetes Mellitus.
PG  - 371-378
LID - 10.2337/dc23-1727 [doi]
AB  - OBJECTIVE: We assessed the relationship of body weight time in target range (TTR) 
      with composite kidney outcome in people with overweight/obesity and type 2 
      diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: Included in this study 
      were 3,601 participants with baseline estimated glomerular filtration rate (eGFR) 
      >/=60 mL/min/1.73 m2 from the Look AHEAD (Action for Health in Diabetes) trial. 
      Body weight TTR was defined as the proportion of time during the first 4 years 
      that body weight was within the weight loss target (a weight loss of >/=7% from 
      baseline). The primary outcome was composite kidney outcome, defined as eGFR 
      decline >/=30% from baseline and to a level <60 mL/min/1.73 m2 at follow-up visit, 
      or end-stage kidney disease. RESULTS: During a median follow-up of 8.0 years, 435 
      cases of composite kidney outcome were documented. Body weight TTR during the 
      first 4 years was inversely associated with the subsequent risk of composite 
      kidney outcome (per SD increment; adjusted hazard ratio [HR] 0.81; 95% CI 
      0.70-0.93). Accordingly, the adjusted HRs (95% CI) of composite kidney outcome 
      were 1.00 (reference), 0.73 (0.54-1.00), 0.71 (0.52-0.99), and 0.54 (0.36-0.80) 
      for participants with body weight TTR of 0%, >0% to <29.9%, 29.9% to <69.7%, and 
      69.7% to <100%, respectively. Similar results were found for a doubling of the 
      urine albumin to creatinine ratio (secondary outcome). CONCLUSIONS: A higher body 
      weight TTR, with a weight loss target of losing >/=7% of initial weight, was 
      associated with a lower risk of kidney outcomes in participants with 
      overweight/obesity and T2DM.
CI  - (c) 2024 by the American Diabetes Association.
FAU - Zu, Cheng
AU  - Zu C
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University; National 
      Clinical Research Center for Kidney Disease; State Key Laboratory of Organ 
      Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong 
      Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - Institute of Biomedicine, Anhui Medical University, Hefei, China.
FAU - Liu, Mengyi
AU  - Liu M
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University; National 
      Clinical Research Center for Kidney Disease; State Key Laboratory of Organ 
      Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong 
      Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
FAU - Su, Xinyue
AU  - Su X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - Institute of Biomedicine, Anhui Medical University, Hefei, China.
FAU - Wei, Yuanxiu
AU  - Wei Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - Institute of Biomedicine, Anhui Medical University, Hefei, China.
FAU - Meng, Qiguo
AU  - Meng Q
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - Institute of Biomedicine, Anhui Medical University, Hefei, China.
FAU - Liu, Chengzhang
AU  - Liu C
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - Institute of Biomedicine, Anhui Medical University, Hefei, China.
FAU - Ye, Ziliang
AU  - Ye Z
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University; National 
      Clinical Research Center for Kidney Disease; State Key Laboratory of Organ 
      Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong 
      Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
FAU - Gan, Xiaoqin
AU  - Gan X
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University; National 
      Clinical Research Center for Kidney Disease; State Key Laboratory of Organ 
      Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong 
      Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
FAU - Zhang, Yuanyuan
AU  - Zhang Y
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University; National 
      Clinical Research Center for Kidney Disease; State Key Laboratory of Organ 
      Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong 
      Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
FAU - He, Panpan
AU  - He P
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University; National 
      Clinical Research Center for Kidney Disease; State Key Laboratory of Organ 
      Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong 
      Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
FAU - Zhou, Chun
AU  - Zhou C
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University; National 
      Clinical Research Center for Kidney Disease; State Key Laboratory of Organ 
      Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong 
      Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
FAU - Hou, Fan Fan
AU  - Hou FF
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University; National 
      Clinical Research Center for Kidney Disease; State Key Laboratory of Organ 
      Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong 
      Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
FAU - Qin, Xianhui
AU  - Qin X
AUID- ORCID: 0000-0001-7812-7982
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University; National 
      Clinical Research Center for Kidney Disease; State Key Laboratory of Organ 
      Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong 
      Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - Institute of Biomedicine, Anhui Medical University, Hefei, China.
LA  - eng
GR  - 2022YFC2009600/National Key Research and Development Program of China/
GR  - D18005/the Program of Introducing Talents of Discipline to Universities, 111 
      Plan/
GR  - 81973133/National Natural Science Foundation of China/
GR  - 2020B1111170013/Guangdong Provincial Clinical Research Center for Kidney Disease/
GR  - 2023B1111030004/Key Technologies R&D Program of Guangdong Province/
PT  - Journal Article
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Overweight/complications
MH  - Kidney
MH  - Obesity/complications
MH  - Weight Loss
MH  - Glomerular Filtration Rate
EDAT- 2023/12/11 18:42
MHDA- 2024/02/26 06:45
CRDT- 2023/12/11 12:14
PHST- 2023/09/13 00:00 [received]
PHST- 2023/11/28 00:00 [accepted]
PHST- 2024/02/26 06:45 [medline]
PHST- 2023/12/11 18:42 [pubmed]
PHST- 2023/12/11 12:14 [entrez]
AID - 153968 [pii]
AID - 10.2337/dc23-1727 [doi]
PST - ppublish
SO  - Diabetes Care. 2024 Mar 1;47(3):371-378. doi: 10.2337/dc23-1727.