PMID- 38081055
OWN - NLM
STAT- MEDLINE
DCOM- 20240105
LR  - 20240119
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 110
IP  - 1
DP  - 2024 Jan 3
TI  - Contextual Factors to Improve Implementation of Malaria Chemoprevention in 
      Children: A Systematic Review.
PG  - 69-78
LID - 10.4269/ajtmh.23-0478 [doi]
AB  - Malaria remains a leading cause of childhood morbidity and mortality in 
      sub-Saharan Africa, particularly among children under 5 years of age. To help 
      address this challenge, the WHO recommends chemoprevention for certain 
      populations. For children and infants, the WHO recommends seasonal malaria 
      chemoprevention (SMC), perennial malaria chemoprevention (PMC; formerly 
      intermittent preventive treatment in infants [IPTi]), and, more recently, 
      intermittent preventive treatment in school children (IPTsc). This review 
      describes the contextual factors, including feasibility, acceptability, health 
      equity, financial considerations, and values and preferences, that impact 
      implementation of these strategies. A systematic search was conducted on July 5, 
      2022, and repeated April 13, 2023, to identify relevant literature. Two reviewers 
      independently screened titles for eligibility, extracted data from eligible 
      articles, and identified and summarized themes. Of 6,295 unique titles 
      identified, 65 were included. The most frequently evaluated strategy was SMC (n = 
      40), followed by IPTi (n = 18) and then IPTsc (n = 6). Overall, these strategies 
      were highly acceptable, although with IPTsc, there were community concerns with 
      providing drugs to girls of reproductive age and the use of nonmedical staff for 
      drug distribution. For SMC, door-to-door delivery resulted in higher coverage, 
      improved caregiver acceptance, and reduced cost. Lower adherence was noted when 
      caregivers were charged with giving doses 2 and 3 unsupervised. For SMC and IPTi, 
      travel distances and inclement weather limited accessibility. Sensitization and 
      caregiver education efforts, retention of high-quality drug distributors, and 
      improved transportation were key to improving coverage. Additional research is 
      needed to understand the role of community values and preferences in 
      chemoprevention implementation.
FAU - Gatiba, Peris
AU  - Gatiba P
AD  - Public Health Institute, Oakland, California.
AD  - Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease 
      Control and Prevention, Atlanta, Georgia.
FAU - Laury, Jessica
AU  - Laury J
AD  - Public Health Institute, Oakland, California.
AD  - Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease 
      Control and Prevention, Atlanta, Georgia.
FAU - Steinhardt, Laura
AU  - Steinhardt L
AD  - Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease 
      Control and Prevention, Atlanta, Georgia.
FAU - Hwang, Jimee
AU  - Hwang J
AD  - U.S. President's Malaria Initiative, Malaria Branch, Centers for Disease Control 
      and Prevention, Atlanta, Georgia.
FAU - Thwing, Julie I
AU  - Thwing JI
AD  - Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease 
      Control and Prevention, Atlanta, Georgia.
FAU - Zulliger, Rose
AU  - Zulliger R
AD  - U.S. President's Malaria Initiative, United States Agency for International 
      Development, Washington, District of Columbia.
FAU - Emerson, Courtney
AU  - Emerson C
AD  - U.S. President's Malaria Initiative, Malaria Branch, Centers for Disease Control 
      and Prevention, Atlanta, Georgia.
FAU - Gutman, Julie R
AU  - Gutman JR
AD  - Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease 
      Control and Prevention, Atlanta, Georgia.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20231211
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Antimalarials)
SB  - IM
MH  - Infant
MH  - Child
MH  - Female
MH  - Humans
MH  - Child, Preschool
MH  - *Antimalarials/therapeutic use
MH  - *Malaria/epidemiology/prevention & control/drug therapy
MH  - Chemoprevention/methods
MH  - Weather
MH  - Caregivers
MH  - Seasons
PMC - PMC10793032
EDAT- 2023/12/11 18:43
MHDA- 2024/01/05 06:42
PMCR- 2025/01/01
CRDT- 2023/12/11 17:33
PHST- 2023/07/24 00:00 [received]
PHST- 2023/09/15 00:00 [accepted]
PHST- 2025/01/01 00:00 [pmc-release]
PHST- 2024/01/05 06:42 [medline]
PHST- 2023/12/11 18:43 [pubmed]
PHST- 2023/12/11 17:33 [entrez]
AID - tpmd230478 [pii]
AID - 10.4269/ajtmh.23-0478 [doi]
PST - epublish
SO  - Am J Trop Med Hyg. 2023 Dec 11;110(1):69-78. doi: 10.4269/ajtmh.23-0478. Print 
      2024 Jan 3.