PMID- 38081489
OWN - NLM
STAT- MEDLINE
DCOM- 20240129
LR  - 20240206
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 257
IP  - Pt 2
DP  - 2024 Feb
TI  - Research on the application of Thelephora ganbajun exopolysaccharides in 
      antioxidant, anti-inflammatory and spot-fading cosmetics.
PG  - 128713
LID - S0141-8130(23)05612-X [pii]
LID - 10.1016/j.ijbiomac.2023.128713 [doi]
AB  - Thelephora ganbajun exopolysaccharides (TGEP) with a "coral-like" branched chain 
      structure (main chain diameter  approximately  80 nm) were prepared by liquid fermentation and 
      fractionated by ion-exchange chromatography. The main fraction (TGEP-2) with the 
      highest in vitro antioxidant capacity was composed of Glc, Man, Gal, GalA, GlcA, 
      Ara, Rha, GlcN, Fuc and Rib in a molar ratio of 
      465.43:420.43:219.14:188.43:37:35.14:31.43:19.43:11.14:1, with a molecular weight 
      of 1.879 x 10(4) Da. The sequence of monosaccharide residue release revealed that 
      Gal, Glc and Ara residues were more distributed in the side-branch chains and at 
      their ends, whereas Man and GalA residues were more distributed in the main 
      chains. TGEP-2 contained linear residues (mainly -->4)-Glcp-(1 --> and -->4)-Manp-(1-->), 
      branch residues (-->3,6)-Glcp-(1-->, -->4,6)-Glcp-(1 --> and -->3,6)-Galp-(1-->) and terminal 
      residues (Galp-(1-->, Manp-(1 --> and Glcp-(1-->). TGEP-2 consisted of alpha- and 
      beta-glycosidically linked pyranosides, with a triple helical conformation and many 
      long branches. Zebrafish oxidative stress and inflammation models found that 
      TGEP-2 had antioxidant and anti-inflammatory activities. The zebrafish skin black 
      spot assay showed that TGEP-2 inhibited melanin formation. Therefore, 
      extracellular polysaccharides of T. ganbajun have strong application potential in 
      anti-oxidant, anti-inflammatory and skin spot-fading functions cosmetics.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Zheng, Lan
AU  - Zheng L
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China. Electronic address: zhenglan24@163.com.
FAU - Yang, Furui
AU  - Yang F
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China.
FAU - Liang, Jie
AU  - Liang J
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China.
FAU - Zhao, Yonglei
AU  - Zhao Y
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China.
FAU - Niu, Junhua
AU  - Niu J
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China.
FAU - Ma, Yaohong
AU  - Ma Y
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China. Electronic address: mayaohong@126.com.
FAU - Meng, Qingjun
AU  - Meng Q
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China.
FAU - Liu, Qingai
AU  - Liu Q
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China.
FAU - Gong, Weili
AU  - Gong W
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China.
FAU - Wang, Binglian
AU  - Wang B
AD  - Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 
      Jinan 250103, China.
LA  - eng
PT  - Journal Article
DEP - 20231209
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Antioxidants)
RN  - 0 (Polysaccharides)
RN  - 0 (Anti-Inflammatory Agents)
RN  - Thelephora ganbajun
SB  - IM
MH  - Humans
MH  - Animals
MH  - *Antioxidants/pharmacology
MH  - *Zebrafish
MH  - Polysaccharides/chemistry
MH  - Anti-Inflammatory Agents/pharmacology
MH  - *Basidiomycota
OTO - NOTNLM
OT  - Melanin formation inhibition
OT  - Polysaccharides
OT  - Thelephora ganbajun
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/12 00:42
MHDA- 2024/01/29 06:43
CRDT- 2023/12/11 19:26
PHST- 2023/08/17 00:00 [received]
PHST- 2023/11/20 00:00 [revised]
PHST- 2023/12/08 00:00 [accepted]
PHST- 2024/01/29 06:43 [medline]
PHST- 2023/12/12 00:42 [pubmed]
PHST- 2023/12/11 19:26 [entrez]
AID - S0141-8130(23)05612-X [pii]
AID - 10.1016/j.ijbiomac.2023.128713 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2024 Feb;257(Pt 2):128713. doi: 
      10.1016/j.ijbiomac.2023.128713. Epub 2023 Dec 9.