PMID- 38084239
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231212
IS  - 1452-8258 (Print)
IS  - 1452-8266 (Electronic)
IS  - 1452-8266 (Linking)
VI  - 42
IP  - 4
DP  - 2023 Oct 27
TI  - The effect of calcium dobesilate combined with hypoglycemic drugs in the 
      treatment of cataract NPDR and its effect on fundus microcirculation and blood 
      ICAM-1, MCP-1 and MIF levels.
PG  - 591-599
LID - 10.5937/jomb0-37338 [doi]
AB  - BACKGROUND: To explore the effect of calcium dobesilate combined with 
      hypoglycemic drugs in the treatment of cataract complicated with 
      non-proliferative diabetic retinopathy (NPDR) and its effects on fundus 
      microcirculation, intercellular adhesion molecule 1 (ICAM-1), mono - cyte 
      chemoattractant protein 1 (MCP-1), and macrophage migration inhibitory factor 
      (MIF). METHODS: From March 2019 to January 2021, a total of 114 patients with 
      cataract and NPDR were included, and the patients were assigned into the control 
      and the observation groups by random number table method, with 57 cases/group. 
      The control was given hypoglycemic drugs, and the observation was given calcium 
      dobesilate combined therapy. The therapeutic efficacy, blood glucose and blood 
      lipid levels, fluorescein fundus angiography results, fundus microcirculation 
      indexes, retinal neovascularizationrelated factors, and ICAM-1, MCP-1, and MIF 
      levels before and after treatment were compared between the two groups. RESULTS: 
      The total effective rate of treatment in the observation was higher vs. the 
      control (P < 0.05); Fasting blood glucose (FBG), 2 h postprandial blood glucose 
      (2hPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholesterol 
      (TC) and low density lipoprotein (LDL) in the observation after treatment were 
      reduced vs. the control (P < 0.05); The number of micro-hemangiomas in the 
      observation after treatment was less vs. the control, and the area of hemorrhage, 
      the area of exudation and the thickness of the yellow plate were smaller vs. the 
      control (P < 0.05); The resistance index (RI) value of the observation after 
      treatment was lower than the control, and the end-diastolic blood flow velocity 
      (EDV) and the peak systolic blood flow velocity (PSV) of the observation were 
      higher vs. the control (P < 0.05). ICAM-1, MCP-1, MIF, vascular endothelial 
      growth factor (VEGF) and insulin-like growth factor-1 (IGF1) in the observation 
      after treatment were reduced vs. the control, but pigment epithelium-derived 
      factor (PEDF) were higher vs. the control (P < 0.05); one case of 
      gastrointestinal reaction took place in the observation, but no adverse reaction 
      occurred in the control, and no clear difference exhibited in the incidence of 
      adverse reactions between the two groups (P > 0.05). CONCLUSIONS: Calcium 
      dobesilate combined with hypoglycemic drugs has good clinical efficacy in the 
      treatment of cataract complicated with NPDR, which can effectively reduce the 
      level of blood glucose and blood lipids, reduce inflammation, and mitigate the 
      microcirculation of branch retinal vein occlusion lesions.
CI  - 2023 XiaoMan Wang, Zhao Zhang, Yi Qing Ge, Xia Wu, Yin Chao Ma, published by 
      CEON/CEES.
FAU - Wang, XiaoMan
AU  - Wang X
AD  - Dingzhou People's Hospital, Department of Pharmacy, Dingzhou City, China.
FAU - Zhang, Zhao
AU  - Zhang Z
AD  - The Fourth Hospital of Zhangjiakou City (Ophthalmology Hospital), Department of 
      Pharmacy, Zhangjiakou City, China.
FAU - Ge, Yi Qing
AU  - Ge YQ
AD  - Shijiazhuang Hospital of Traditional Chinese Medicine, Department of Pharmacy, 
      Shijiazhuang City, China.
FAU - Wu, Xia
AU  - Wu X
AD  - Shijiazhuang Hospital of Traditional Chinese Medicine, Department of Pharmacy, 
      Shijiazhuang City, China.
FAU - Ma, Yin Chao
AU  - Ma YC
AD  - The Fourth Hospital of Zhangjiakou City (Ophthalmology Hospital), Department of 
      Pharmacy, Zhangjiakou City, China.
LA  - eng
PT  - Journal Article
PL  - Serbia
TA  - J Med Biochem
JT  - Journal of medical biochemistry
JID - 101315490
PMC - PMC10710796
OTO - NOTNLM
OT  - calcium dobesilate
OT  - cataract with nonproliferative diabetic retinopathy
OT  - combination therapy
OT  - fundus microcirculation
OT  - intercellular adhesion molecule 1
OT  - macrophage migration inhibitory factor
OT  - monocyte chemotactic protein 1
COIS- All the authors declare that they have no conflict of interest in this 
      work.Conflict of Interest: The authors stated that they have no conflicts of 
      interest regarding the publication of this article.
EDAT- 2023/12/12 06:42
MHDA- 2023/12/12 06:43
PMCR- 2023/10/27
CRDT- 2023/12/12 03:37
PHST- 2022/09/15 00:00 [received]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2023/12/12 06:43 [medline]
PHST- 2023/12/12 06:42 [pubmed]
PHST- 2023/12/12 03:37 [entrez]
PHST- 2023/10/27 00:00 [pmc-release]
AID - jomb-42-4-2304591W [pii]
AID - 10.5937/jomb0-37338 [doi]
PST - ppublish
SO  - J Med Biochem. 2023 Oct 27;42(4):591-599. doi: 10.5937/jomb0-37338.