PMID- 38085287
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240206
IS  - 2731-7218 (Electronic)
IS  - 2731-720X (Linking)
VI  - 121
IP  - Suppl 1
DP  - 2024 Jan
TI  - HLA-B27-positive anterior uveitis : Clinical aspects, diagnostics, 
      interdisciplinary management, and treatment.
PG  - 12-22
LID - 10.1007/s00347-023-01960-z [doi]
AB  - Acute anterior uveitis (AAU) associated with human leukocyte antigen (HLA) B27 is 
      the most common form of noninfectious intraocular inflammation and is considered 
      to be a separate clinical entity. Young adults between the ages of 20 and 40 
      years are predominantly affected. The HLA-B27 positive AAU typically presents as 
      a unilateral, fulminant disruption of the blood-aqueous humor barrier, which is 
      accompanied by pronounced cellular infiltration and fibrinous exudation. Other 
      characteristics are reduced intraocular pressure and a high tendency to relapse, 
      which can also involve the partner eye. Patients with HLA-B27 positive AAU share 
      a high risk for other genetically associated diseases, especially 
      spondylarthritis, chronic inflammatory bowel diseases and psoriasis. As up to 40% 
      of those affected have a systemic disease that has not yet been diagnosed, the 
      ophthalmologist is of major importance for early detection.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, 
      ein Teil von Springer Nature.
FAU - Werkl, Peter
AU  - Werkl P
AD  - Universitatsaugenklinik Graz-LKH-Universitatsklinikum Graz, Medizinische 
      Universitat Graz, Auenbruggerplatz 4, 8036, Graz, Austria.
FAU - Rademacher, Judith
AU  - Rademacher J
AD  - Medizinische Klinik fur Gastroenterologie, Infektiologie und Rheumatologie, 
      Division of Gastroenterology, Infectious Diseases and Rheumatology, 
      Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, 
      Humboldt-Universitat zu Berlin, and Berlin Institute of Health, 
      Hindenburgdamm 30, 12203, Berlin, Germany.
AD  - Berlin Institute of Health at Charite-Universitatsmedizin Berlin, Chariteplatz 1, 
      10117, Berlin, Germany.
FAU - Pleyer, Uwe
AU  - Pleyer U
AD  - Berlin Institute of Health at Charite-Universitatsmedizin Berlin, Chariteplatz 1, 
      10117, Berlin, Germany. uwe.pleyer@charite.de.
AD  - Universitats-Augenklinik, Charite, Campus Virchow Klinikum-Universitatsmedizin 
      Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu 
      Berlin, und Berlin Institute of Health, 13355, Berlin, Germany. 
      uwe.pleyer@charite.de.
LA  - eng
PT  - Journal Article
PT  - Review
TT  - HLA-B27-positive Uveitis anterior : Klinik, Diagnostik, interdisziplinares 
      Management und Therapie. Englische Version.
DEP - 20231212
PL  - Germany
TA  - Ophthalmologie
JT  - Die Ophthalmologie
JID - 9918402288106676
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Young Adult
MH  - Humans
MH  - Adult
MH  - HLA-B27 Antigen/genetics
MH  - *Uveitis, Anterior/diagnosis
MH  - *Uveitis
MH  - Inflammation
MH  - *Spondylarthritis
MH  - Acute Disease
MH  - Chronic Disease
OTO - NOTNLM
OT  - Acute anterior uveitis
OT  - Clinical manifestations
OT  - Psoriasis
OT  - Spondylarthritis
OT  - Systemic disease
EDAT- 2023/12/12 12:41
MHDA- 2024/02/05 06:44
CRDT- 2023/12/12 11:04
PHST- 2023/11/08 00:00 [accepted]
PHST- 2024/02/05 06:44 [medline]
PHST- 2023/12/12 12:41 [pubmed]
PHST- 2023/12/12 11:04 [entrez]
AID - 10.1007/s00347-023-01960-z [pii]
AID - 10.1007/s00347-023-01960-z [doi]
PST - ppublish
SO  - Ophthalmologie. 2024 Jan;121(Suppl 1):12-22. doi: 10.1007/s00347-023-01960-z. 
      Epub 2023 Dec 12.