PMID- 38085445
OWN - NLM
STAT- MEDLINE
DCOM- 20240206
LR  - 20240208
IS  - 1348-2246 (Electronic)
IS  - 0910-6340 (Linking)
VI  - 40
IP  - 2
DP  - 2024 Feb
TI  - Preparation of a novel MOF-POPM and its application in online purification and 
      enrichment of oleanolic acid in medicinal plants.
PG  - 319-333
LID - 10.1007/s44211-023-00465-8 [doi]
AB  - In present work, a method for enrichment, purification, and content determination 
      of oleanolic acid (OA) in medicinal plants was established based on on-line solid 
      phase extraction (SPE). A metal organic frameworks-porous organic polymer 
      monolith (MOF-POPM) was prepared with functionalized UiO-66-(OH)(2) as monomer 
      and was used as SPE column for online enrichment and purification of OA. The 
      ratio of adsorbent, enriching and eluting solvent, mobile phase pH, and flow rate 
      had been systematically investigated. Under the optimum conditions, the linear 
      range of OA was 0.59-2500 mug/mL with r = 0.9996. The limit of detection (LOD) was 
      0.18 mug/mL and the limit of quantification (LOQ) was 0.59 mug/mL. The intra-day 
      relative standard deviations (RSDs) and inter-day RSDs of retention time and peak 
      area were less than 0.3% and 1.3%, respectively. The average recoveries of OA in 
      medicinal plants samples ranged from 87.7 to 104.6%. The results demonstrated 
      that the online system was reliable and accurate for enrichment, purification, 
      and content determination of OA in medicinal plants.
CI  - (c) 2023. The Author(s), under exclusive licence to The Japan Society for 
      Analytical Chemistry.
FAU - Zhang, Miaomiao
AU  - Zhang M
AD  - College of Pharmaceutical Sciences, Key Laboratory of Public Health Safety of 
      Hebei Province; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of 
      Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations 
      and Excipients, Hebei University, Baoding, 071002, China.
FAU - Wei, Xuanwen
AU  - Wei X
AD  - College of Pharmaceutical Sciences, Key Laboratory of Public Health Safety of 
      Hebei Province; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of 
      Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations 
      and Excipients, Hebei University, Baoding, 071002, China.
FAU - Bai, Ligai
AU  - Bai L
AD  - College of Pharmaceutical Sciences, Key Laboratory of Public Health Safety of 
      Hebei Province; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of 
      Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations 
      and Excipients, Hebei University, Baoding, 071002, China.
FAU - Liu, Haiyan
AU  - Liu H
AD  - College of Pharmaceutical Sciences, Key Laboratory of Public Health Safety of 
      Hebei Province; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of 
      Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations 
      and Excipients, Hebei University, Baoding, 071002, China. lhy1610@126.com.
LA  - eng
GR  - 21974034/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20231212
PL  - Switzerland
TA  - Anal Sci
JT  - Analytical sciences : the international journal of the Japan Society for 
      Analytical Chemistry
JID - 8511078
RN  - 6SMK8R7TGJ (Oleanolic Acid)
RN  - 0 (Polymers)
SB  - IM
MH  - *Oleanolic Acid
MH  - *Plants, Medicinal
MH  - Chromatography, High Pressure Liquid/methods
MH  - Solid Phase Extraction/methods
MH  - Polymers/chemistry
OTO - NOTNLM
OT  - Enrichment
OT  - Medicinal plants
OT  - Metal organic frameworks
OT  - Oleanolic acid
OT  - Solid-phase extraction
EDAT- 2023/12/12 12:41
MHDA- 2024/02/06 06:42
CRDT- 2023/12/12 11:15
PHST- 2023/06/20 00:00 [received]
PHST- 2023/10/30 00:00 [accepted]
PHST- 2024/02/06 06:42 [medline]
PHST- 2023/12/12 12:41 [pubmed]
PHST- 2023/12/12 11:15 [entrez]
AID - 10.1007/s44211-023-00465-8 [pii]
AID - 10.1007/s44211-023-00465-8 [doi]
PST - ppublish
SO  - Anal Sci. 2024 Feb;40(2):319-333. doi: 10.1007/s44211-023-00465-8. Epub 2023 Dec 
      12.