PMID- 38086307
OWN - NLM
STAT- MEDLINE
DCOM- 20240101
LR  - 20240106
IS  - 1873-4235 (Electronic)
IS  - 0956-5663 (Linking)
VI  - 246
DP  - 2024 Feb 15
TI  - Dielectrophoretic force-induced wrinkling of graphene oxide: Enhancing electrical 
      conductivity and expanding biosensing applications.
PG  - 115867
LID - S0956-5663(23)00809-6 [pii]
LID - 10.1016/j.bios.2023.115867 [doi]
AB  - Graphene oxide (GO) has many advantages, making it suitable for various 
      applications. However, it has low electrical conductivity, restricting its 
      applicability to electrochemical biosensors. This study used dielectrophoretic 
      (DEP) force to control the movement and deformation of GO nanosheets to achieve 
      high electrical conductivity without the chemical reduction of oxygen functional 
      groups. Subjecting the DEP force to GO nanosheets induced physical deformation 
      leading to the formation of wrinkled structures. A computational simulation was 
      performed to set an appropriate electrical condition for operating a positive DEP 
      force effect of at least 10(19) v(2)/m(3), and the interdigitated microelectrode 
      structure was selected. The resulting wrinkled GO exhibited significantly 
      improved electrical conductivity, reaching 21.721 muS while preserving the 
      essential oxygen functional groups. Furthermore, a biosensor was fabricated using 
      wrinkled GO deposited via DEP force. The biosensor demonstrated superior 
      sensitivity, exhibiting a 9.6-fold enhancement compared with reduced GO (rGO) 
      biosensors, as demonstrated through biological experiments targeting inducible 
      nitric oxide synthase. This study highlights the potential of using DEP force to 
      enhance electrical conductivity in GO-based biosensing applications, opening new 
      avenues for high-performance diagnostics.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Park, Yejin
AU  - Park Y
AD  - Department of Biomedical Engineering, College of Life Science and Biotechnology, 
      Dongguk University, Seoul 04620, Republic of Korea.
FAU - Kim, Hyejin
AU  - Kim H
AD  - Institute of Chemical Processes (ICP), Seoul National University, Seoul 08826, 
      Republic of Korea; Center for Nanoparticle Research, Institute for Basic Science 
      (IBS), Seoul National University, Seoul 08826, Republic of Korea.
FAU - Song, Jaeyoon
AU  - Song J
AD  - Department of Biomedical Engineering, College of Life Science and Biotechnology, 
      Dongguk University, Seoul 04620, Republic of Korea.
FAU - Kim, Sehyeon
AU  - Kim S
AD  - Department of Biomedical Engineering, College of Life Science and Biotechnology, 
      Dongguk University, Seoul 04620, Republic of Korea.
FAU - Lee, Byung Chul
AU  - Lee BC
AD  - Bionics Research Center, Korea Institute of Science and Technology (KIST), Seoul, 
      02792, Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee 
      University, Seoul, 02447, Korea.
FAU - Kim, Jinsik
AU  - Kim J
AD  - Department of Biomedical Engineering, College of Life Science and Biotechnology, 
      Dongguk University, Seoul 04620, Republic of Korea. Electronic address: 
      lookup2@dongguk.edu.
LA  - eng
PT  - Journal Article
DEP - 20231130
PL  - England
TA  - Biosens Bioelectron
JT  - Biosensors & bioelectronics
JID - 9001289
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Biosensing Techniques/methods
MH  - Oxidation-Reduction
MH  - Electric Conductivity
MH  - *Graphite/chemistry
MH  - Oxygen
OTO - NOTNLM
OT  - Biosensor
OT  - Chemical reduction
OT  - Dielectrophoretic force
OT  - Electrical conductivity
OT  - Graphene oxide
OT  - Wrinkles
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/13 00:41
MHDA- 2024/01/02 11:45
CRDT- 2023/12/12 18:09
PHST- 2023/08/20 00:00 [received]
PHST- 2023/11/19 00:00 [revised]
PHST- 2023/11/20 00:00 [accepted]
PHST- 2024/01/02 11:45 [medline]
PHST- 2023/12/13 00:41 [pubmed]
PHST- 2023/12/12 18:09 [entrez]
AID - S0956-5663(23)00809-6 [pii]
AID - 10.1016/j.bios.2023.115867 [doi]
PST - ppublish
SO  - Biosens Bioelectron. 2024 Feb 15;246:115867. doi: 10.1016/j.bios.2023.115867. 
      Epub 2023 Nov 30.