PMID- 38087399
OWN - NLM
STAT- MEDLINE
DCOM- 20240321
LR  - 20240321
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 104
IP  - 6
DP  - 2024 Apr
TI  - Integrated metabolomics and network pharmacology to reveal the lipid-lowering 
      mechanisms of Qizha Shuangye granules in hyperlipidemic rats.
PG  - 3265-3274
LID - 10.1002/jsfa.13213 [doi]
AB  - BACKGROUND: Qizha Shuangye granules (QSG) comprise six traditional Chinese herbal 
      medicines (TCHMs), which have a long history of treating hyperlipidemia (HLP) in 
      China. This study aimed to evaluate the potential lipid-lowering effects of QSG 
      in an HLP rat model and investigate possible mechanisms. The HLP rat model was 
      induced by a high-fat diet. Lipid-related indicators in serum were detected. 
      Serum and liver metabolites were investigated using a liquid chromatography-mass 
      spectrometry-based metabolomics approach. A herb-compound-target-metabolite 
      (H-C-T-M) network was further constructed to reveal the possible molecular 
      mechanism of QSG to alleviate HLP. RESULTS: The administration of QSG inhibited 
      the HLP-induced changes in total cholesterol, triglyceride, low-density 
      lipoprotein cholesterol, high-density lipoprotein cholesterol, and non-esterified 
      fatty acid (NEFA) levels. Additionally, QSG significantly attenuated the liver 
      histopathological changes induced by HLP. Metabolomic analysis showed the serum 
      and liver metabolic disorders presented in HLP rats. QSG can reverse the abnormal 
      metabolism caused by HLP. Through network pharmacology analysis, key proteins 
      such as androgen receptor, 3-hydroxy-3-methylglutaryl-CoA reductase, and 
      peroxisome proliferator-activated receptor-alpha were screened out, and they were 
      speculated to be possible therapeutic targets for QSG to treat HLP. CONCLUSION: 
      The present study integrated metabolomics and network pharmacology analysis to 
      reveal the efficacy and possible mechanism of QSG in treating HLP, which provides 
      a new reference for the research and development of QSG as a functional food. (c) 
      2023 Society of Chemical Industry.
CI  - (c) 2023 Society of Chemical Industry.
FAU - Zhao, Liang
AU  - Zhao L
AD  - School of Chinese Materia Medica, Beijing University of Chinese Medicine, 
      Beijing, China.
AD  - College of Pharmacy, Yanbian University, Yanji, China.
AD  - Key Laboratory of Medicinal Materials, Jilin Academy of Chinese Medicine 
      Sciences, Changchun, China.
FAU - Wang, Shuyue
AU  - Wang S
AD  - School of Chinese Materia Medica, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Xu, Xiaohang
AU  - Xu X
AD  - Key Laboratory of Medicinal Materials, Jilin Academy of Chinese Medicine 
      Sciences, Changchun, China.
FAU - Guo, Wenjun
AU  - Guo W
AD  - Key Laboratory of Medicinal Materials, Jilin Academy of Chinese Medicine 
      Sciences, Changchun, China.
FAU - Yang, Jingxuan
AU  - Yang J
AD  - Key Laboratory of Medicinal Materials, Jilin Academy of Chinese Medicine 
      Sciences, Changchun, China.
FAU - Liu, Yue
AU  - Liu Y
AD  - Key Laboratory for Analysis Methods of Active Ingredients in Traditional Chinese 
      Medicine, Jilin Academy of Chinese Medicine Sciences, Changchun, China.
FAU - Xie, Shengxu
AU  - Xie S
AD  - Key Laboratory for Analysis Methods of Active Ingredients in Traditional Chinese 
      Medicine, Jilin Academy of Chinese Medicine Sciences, Changchun, China.
FAU - Piao, Guangchun
AU  - Piao G
AD  - College of Pharmacy, Yanbian University, Yanji, China.
AD  - Key Laboratory for Natural Resource of Changbai Mountain, Yanbian University, 
      Yanji, China.
FAU - Xu, Tunhai
AU  - Xu T
AD  - School of Chinese Materia Medica, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Wang, Yang
AU  - Wang Y
AUID- ORCID: 0000-0002-2582-7480
AD  - Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 
      China.
FAU - Xu, Yajuan
AU  - Xu Y
AD  - Key Laboratory of Medicinal Materials, Jilin Academy of Chinese Medicine 
      Sciences, Changchun, China.
LA  - eng
GR  - 2022C033-3/Basic Construction Funds within the budget of Jilin Province in 2020/
PT  - Journal Article
DEP - 20231222
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Network Pharmacology
MH  - Metabolomics
MH  - *Hyperlipidemias/drug therapy
MH  - *Drugs, Chinese Herbal/pharmacology
MH  - Triglycerides
MH  - Cholesterol
OTO - NOTNLM
OT  - Qizha Shuangye granules
OT  - hyperlipidemia
OT  - liquid chromatography-mass spectrometry
OT  - metabolomics
OT  - network pharmacology
EDAT- 2023/12/13 06:42
MHDA- 2024/03/21 12:48
CRDT- 2023/12/13 00:15
PHST- 2023/11/02 00:00 [revised]
PHST- 2023/08/14 00:00 [received]
PHST- 2023/12/09 00:00 [accepted]
PHST- 2024/03/21 12:48 [medline]
PHST- 2023/12/13 06:42 [pubmed]
PHST- 2023/12/13 00:15 [entrez]
AID - 10.1002/jsfa.13213 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2024 Apr;104(6):3265-3274. doi: 10.1002/jsfa.13213. Epub 2023 
      Dec 22.