PMID- 38088883
OWN - NLM
STAT- MEDLINE
DCOM- 20240229
LR  - 20240307
IS  - 1533-4287 (Electronic)
IS  - 1064-8011 (Linking)
VI  - 38
IP  - 3
DP  - 2024 Mar 1
TI  - Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers 
      in Untrained Perimenopausal and Postmenopausal Women.
PG  - 526-532
LID - 10.1519/JSC.0000000000004661 [doi]
AB  - Chapman-Lopez, TJ, Funderburk, LK, Heileson, JL, Wilburn, DT, Koutakis, P, 
      Gallucci, AR, and Forsse, JS. Effects of L-leucine supplementation and resistance 
      training on adipokine markers in untrained perimenopausal and postmenopausal 
      women. J Strength Cond Res 38(3): 526-532, 2024-This study examined the effects 
      of supplementing 5 g of leucine compared with a placebo during a 10-week 
      resistance training program on body composition parameters and adipokine 
      concentrations in untrained, perimenopausal and postmenopausal women. Thirty-five 
      women were randomly assigned to 2 groups-leucine (LEU, n = 17) and placebo (PLC, 
      n = 18)-in a double-blind, placebo-controlled trial. Each group consumed the 
      supplement or placebo every day and completed a resistance training program for 
      10 weeks. Using 3-day food records, a diet was assessed before the intervention 
      and after its cessation. Body composition was assessed preintervention and 
      postintervention using dual-energy x-ray absorptiometry. Moreover, the 
      concentrations of adipokines, such as adiponectin, visfatin, leptin, and monocyte 
      chemoattractant protein-1 (MCP-1), were assessed preintervention and 
      postintervention. Both groups showed an increase in visceral adipose tissue (VAT) 
      area ( p = 0.030) and fat-free mass (FFM; p = 0.023). There were significant 
      group differences in concentrations of visfatin ( p = 0.020) and leptin ( p = 
      0.038) between the PLC and LEU groups. Visfatin displayed higher concentrations 
      in the PLC group and leptin displayed higher concentrations in the LEU group. In 
      addition, there were significant decreases in adiponectin concentrations for both 
      groups (LEU: 652 +/- 513 to 292 +/- 447 pg.ml -1 ; PLC: 584 +/- 572 to 245 +/- 356 pg.ml 
      -1 , p = 0.002) and MCP-1 only decreased in the PLC group (253 +/- 119 to 206 +/- 106 
      pg.ml -1 , p = 0.004). There were significant decreases in adiponectin 
      concentrations in both groups and a decrease in MCP-1 concentrations in the PLC 
      group. These decreases may be due to both adipokines possible relationship with 
      VAT area. However, it is not known whether leucine has underlying properties that 
      hinder changes in MCP-1 concentrations.
CI  - Copyright (c) 2023 National Strength and Conditioning Association.
FAU - Chapman-Lopez, Tomas J
AU  - Chapman-Lopez TJ
AD  - Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, 
      Department of Health Human Performance and Recreation, Baylor University, Waco, 
      Texas.
FAU - Funderburk, LesLee K
AU  - Funderburk LK
AD  - Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, 
      Department of Health Human Performance and Recreation, Baylor University, Waco, 
      Texas.
AD  - Human Sciences and Design, Baylor University, Waco, Texas.
FAU - Heileson, Jeffery L
AU  - Heileson JL
AD  - Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, 
      Department of Health Human Performance and Recreation, Baylor University, Waco, 
      Texas.
AD  - Nutrition Services Division, Walter Reed National Military Medical Center, 
      Bethesda, Maryland; and.
FAU - Wilburn, Dylan T
AU  - Wilburn DT
AD  - Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, 
      Department of Health Human Performance and Recreation, Baylor University, Waco, 
      Texas.
FAU - Koutakis, Panagiotis
AU  - Koutakis P
AD  - Clinical Muscle Biology Lab, Baylor University, Waco, Texas.
FAU - Gallucci, Andrew R
AU  - Gallucci AR
AD  - Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, 
      Department of Health Human Performance and Recreation, Baylor University, Waco, 
      Texas.
FAU - Forsse, Jeffrey S
AU  - Forsse JS
AUID- ORCID: 0000-0001-8326-5132
AD  - Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, 
      Department of Health Human Performance and Recreation, Baylor University, Waco, 
      Texas.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20231213
PL  - United States
TA  - J Strength Cond Res
JT  - Journal of strength and conditioning research
JID - 9415084
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Leptin)
RN  - GMW67QNF9C (Leucine)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
SB  - IM
MH  - Female
MH  - Humans
MH  - Adipokines/pharmacology
MH  - Adiponectin
MH  - Body Composition
MH  - Dietary Supplements
MH  - *Leptin
MH  - Leucine/pharmacology
MH  - Nicotinamide Phosphoribosyltransferase/pharmacology
MH  - Perimenopause
MH  - Postmenopause
MH  - *Resistance Training
MH  - Double-Blind Method
EDAT- 2023/12/13 18:42
MHDA- 2024/02/29 06:43
CRDT- 2023/12/13 12:03
PHST- 2024/02/29 06:43 [medline]
PHST- 2023/12/13 18:42 [pubmed]
PHST- 2023/12/13 12:03 [entrez]
AID - 00124278-990000000-00360 [pii]
AID - 10.1519/JSC.0000000000004661 [doi]
PST - ppublish
SO  - J Strength Cond Res. 2024 Mar 1;38(3):526-532. doi: 10.1519/JSC.0000000000004661. 
      Epub 2023 Dec 13.