PMID- 38090120
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231213
IS  - 2211-5587 (Print)
IS  - 2211-5595 (Electronic)
IS  - 2211-5587 (Linking)
VI  - 13
IP  - 4
DP  - 2023 Dec
TI  - Comparison of Ventilator Mechanics and Mortality Between COVID-19 Versus 
      Non-COVID-19 Acute Respiratory Distress Syndrome Patients: A Cross-Sectional 
      Study.
PG  - 144-149
LID - 10.6705/j.jacme.202312_13(4).0002 [doi]
AB  - BACKGROUND: We aim to assess the differences in ventilator mechanics and 
      mortality of acute respiratory distress syndrome (ARDS) between patients with and 
      without COVID-19. It might serve as a milestone in reshaping management protocols 
      by providing very preliminary evidence in this direction. METHODS: It was a 
      cross-sectional study that included adult patients aged 18 years or above 
      admitted to the medical intensive care unit of our tertiary care hospital from 
      January to December 2021 with the diagnosis of ARDS. Patients were divided into 
      two groups. Group I were patients who had ARDS with COVID-19 infection while 
      group II were those who had ARDS without COVID-19 infection. Both groups were 
      compared in terms of clinical and respiratory mechanics of mechanical ventilators 
      and mortality. RESULTS: The study included 135 patients, 68 of whom were in group 
      I, and 67 were in group II. In the COVID-19 group, the median age was 60; while 
      in the non-COVID-19 group, it was 64. There were 50% male patients in both 
      groups. ARDS was more severe in COVID-19 (n = 44, 58%) than in the non-COVID 
      group (n = 31, 41.3%, p-value = 0.030). The median PaO(2)/FiO(2) ratio was 122.5 
      (interquartile range [IQR]: 93-160) in COVID-19 and was 180 (IQR: 127-248) in the 
      non-COVID-19 group. Patient proning was higher (63% vs. 37%) in the COVID-19 
      group. In the COVID-19 group, 44 patients died compared to 32 in the non-COVID 
      group (p-value = 0.060). CONCLUSIONS: COVID-19 patients had severe ARDS compared 
      with non-COVID patients. Despite this, ventilator mechanics and mortality were 
      not significantly different between both groups. It appears that more proning 
      strategies were observed in the COVID-19 group and may have some positive 
      effects.
CI  - Copyright (c) 2023 by Taiwan Society of Emergency Medicine & Ainosco Press. All 
      Rights Reserved.
FAU - Hanif, Sadaf
AU  - Hanif S
AD  - Internal Medicine, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Iqbal, Madiha
AU  - Iqbal M
AD  - Internal Medicine, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Sethi, Sher Muhammad
AU  - Sethi SM
AD  - Internal Medicine, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Sabeen, Amber
AU  - Sabeen A
AD  - Internal Medicine, Aga Khan University Hospital, Karachi, Pakistan.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - J Acute Med
JT  - Journal of acute medicine
JID - 101574304
PMC - PMC10711365
OTO - NOTNLM
OT  - COVID-19
OT  - hypoxia
OT  - positive pressure ventilation
OT  - respiratory distress syndrome
OT  - respiratory insufficiency
COIS- Nothing to declare.
EDAT- 2023/12/13 18:42
MHDA- 2023/12/13 18:43
PMCR- 2023/12/01
CRDT- 2023/12/13 13:04
PHST- 2022/09/13 00:00 [received]
PHST- 2022/01/03 00:00 [revised]
PHST- 2023/01/19 00:00 [accepted]
PHST- 2023/12/13 18:43 [medline]
PHST- 2023/12/13 18:42 [pubmed]
PHST- 2023/12/13 13:04 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - 10.6705/j.jacme.202312_13(4).0002 [doi]
PST - ppublish
SO  - J Acute Med. 2023 Dec;13(4):144-149. doi: 10.6705/j.jacme.202312_13(4).0002.