PMID- 38090261
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231213
IS  - 2666-027X (Electronic)
IS  - 2666-027X (Linking)
VI  - 5
DP  - 2023
TI  - Association between metal mixture exposure and abnormal glucose metabolism in 
      multiple mixture exposure models: Evidence from NHANES 2015-2016.
PG  - 100141
LID - 10.1016/j.crtox.2023.100141 [doi]
LID - 100141
AB  - Previous studies primarily focused on the single metal exposure and one-sided 
      glucose metabolism disordered states, leading to conflicting results. Herein, we 
      combined diabetes and prediabetes as abnormal glucose metabolism (AGM) to 
      describe the effect of metal mixture exposure on it. Eligible data were obtained 
      from the National Health and Nutrition Examination Survey (NHANES) 2015-2016. In 
      the generalized linear model (GLM), Cd (OR: 1.060, 95 %CI: 1.032-1.089, P 
      value < 0.001) and Tl (OR: 1.039, 95 %CI: 1.004-1.075, P value = 0.031) exposure 
      were positively associated with AGM. In the weighted quantile sum (WQS) 
      regression model, the positive index was obviously associated with AGM (OR: 
      1.358, 95 %CI: 1.007-1.832, P value = 0.045). In the least absolute shrinkage and 
      selection operator (LASSO) regression model, Cd and Tl were selected as the most 
      contributors. In the Bayesian kernel machine regression (BKMR) model, the effect 
      of co-exposure to metal mixture was associated with AGM, and Cd exposure showed a 
      significantly positive trend. In conclusion, Cd and Tl exposure exhibited 
      independent positive effects on AGM among metal mixture exposure, consistent with 
      their effects on prediabetes.
CI  - (c) 2023 Published by Elsevier B.V.
FAU - Zhu, Jiamin
AU  - Zhu J
AD  - State Key Laboratory of Reproductive Medicine, Women's Hospital of Nanjing 
      Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 
      Medical University, Nanjing, China.
FAU - Hu, Shiman
AU  - Hu S
AD  - State Key Laboratory of Reproductive Medicine, Women's Hospital of Nanjing 
      Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 
      Medical University, Nanjing, China.
FAU - Wang, Shanshan
AU  - Wang S
AD  - State Key Laboratory of Reproductive Medicine, Women's Hospital of Nanjing 
      Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 
      Medical University, Nanjing, China.
FAU - Zhang, Yuting
AU  - Zhang Y
AD  - State Key Laboratory of Reproductive Medicine, Women's Hospital of Nanjing 
      Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 
      Medical University, Nanjing, China.
FAU - Zhu, Qingyi
AU  - Zhu Q
AD  - State Key Laboratory of Reproductive Medicine, Women's Hospital of Nanjing 
      Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 
      Medical University, Nanjing, China.
FAU - Zhang, Mingzhi
AU  - Zhang M
AD  - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of 
      Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
AD  - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public 
      Health, Nanjing Medical University, Nanjing, Jiangsu, China.
FAU - Shi, Zhonghua
AU  - Shi Z
AD  - State Key Laboratory of Reproductive Medicine, Women's Hospital of Nanjing 
      Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 
      Medical University, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20231201
PL  - Netherlands
TA  - Curr Res Toxicol
JT  - Current research in toxicology
JID - 101771915
PMC - PMC10714339
OTO - NOTNLM
OT  - Abnormal glucose metabolism
OT  - Co-exposure
OT  - Diabetes
OT  - Machine learning
OT  - Metals
OT  - Prediabetes
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/12/13 18:42
MHDA- 2023/12/13 18:43
PMCR- 2023/12/01
CRDT- 2023/12/13 13:06
PHST- 2023/08/07 00:00 [received]
PHST- 2023/10/31 00:00 [revised]
PHST- 2023/11/30 00:00 [accepted]
PHST- 2023/12/13 18:43 [medline]
PHST- 2023/12/13 18:42 [pubmed]
PHST- 2023/12/13 13:06 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - S2666-027X(23)00039-7 [pii]
AID - 100141 [pii]
AID - 10.1016/j.crtox.2023.100141 [doi]
PST - epublish
SO  - Curr Res Toxicol. 2023 Dec 1;5:100141. doi: 10.1016/j.crtox.2023.100141. 
      eCollection 2023.