PMID- 38090319
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231213
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 15
IP  - 11
DP  - 2023 Nov 30
TI  - A signature of five 7-methylguanosine-related genes is a prognostic marker for 
      lung squamous cell carcinoma.
PG  - 6265-6278
LID - 10.21037/jtd-23-1504 [doi]
AB  - BACKGROUND: N(7)-methylguanosine (m7G) is an important posttranscriptional 
      modification affecting mRNA and tRNA functions and stability. The genes 
      regulating the m7G process have been previously found involved in the 
      carcinogenesis process. We aimed to analyze the role of m7G-related genes as 
      potential prognostic markers for lung squamous cell carcinoma (LSCC). METHODS: 
      Twenty-nine m7G-related genes were selected for the analysis in the LSCC cohort 
      of the Cancer Genome Atlas (TCGA). Univariate, multivariate, and Kaplan-Meier 
      analyses were used to evaluate the predictive value of risk model developed with 
      m7G signature for overall survival (OS).. The Gene Ontology (GO) and Kyoto 
      Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of 
      differentially expressed genes (DEGs) were performed for high- and low-risk LSCC 
      groups. RESULTS: We identified 17 differentially expressed m7G 
      methylation-related genes in LSCC versus normal tissues. The expression of five 
      m7G-related genes (EIF3D, LSM1, NCBP2, NUDT10, and NUDT11) was identified as an 
      independent prognostic marker for OS in LSCC patients. A risk model with these 
      five m7G-related genes predicted 2-, and 3-year survival rates of 0.623 and 
      0.626, respectively. The risk score significantly correlated with OS: LSCC 
      patients with a higher risk score had shorter OS (P<0.01) and it was associated 
      with lower immune response (P<0.01). CONCLUSIONS: We developed a novel 
      m7G-related gene signature that can be of great utility to predict the prognosis 
      for patients with LSCC.
CI  - 2023 Journal of Thoracic Disease. All rights reserved.
FAU - Liu, Wensheng
AU  - Liu W
AD  - Critical Care Medicine Department, Zhejiang Cancer Hospital, Hangzhou, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Gynecological Oncology Department, Zhejiang Cancer Hospital, Hangzhou, China.
FAU - Ulivi, Paola
AU  - Ulivi P
AD  - Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino 
      Amadori" (IRST), Meldola, Italy.
FAU - Tavolari, Simona
AU  - Tavolari S
AD  - Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, 
      Italy.
FAU - Rizvi, Syed A A
AU  - Rizvi SAA
AD  - College of Biomedical Sciences, Larkin University, Miami, FL, USA.
FAU - Capobianco, Enrico
AU  - Capobianco E
AD  - Department of Computational Science, The Jackson Laboratory, Farmington, CT, USA.
FAU - Navarro, Alfons
AU  - Navarro A
AD  - Molecular Oncology and Embryology Laboratory, Department of Surgery and Surgical 
      Specializations, Human Anatomy Unit, Faculty of Medicine and Health Sciences, 
      University of Barcelona (UB), Barcelona, Spain.
FAU - Zhang, Yongjun
AU  - Zhang Y
AD  - Integration of Traditional Chinese and Western Medicine Department, Zhejiang 
      Cancer Hospital, Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20231127
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC10713324
OTO - NOTNLM
OT  - N7-methylguanosine (m7G)
OT  - Non-small cell lung cancer (NSCLC)
OT  - The Cancer Genome Atlas (TCGA)
OT  - biomarker
OT  - prognosis
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://jtd.amegroups.com/article/view/10.21037/jtd-23-1504/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2023/12/13 18:42
MHDA- 2023/12/13 18:43
PMCR- 2023/11/30
CRDT- 2023/12/13 13:07
PHST- 2023/09/26 00:00 [received]
PHST- 2023/11/09 00:00 [accepted]
PHST- 2023/12/13 18:43 [medline]
PHST- 2023/12/13 18:42 [pubmed]
PHST- 2023/12/13 13:07 [entrez]
PHST- 2023/11/30 00:00 [pmc-release]
AID - jtd-15-11-6265 [pii]
AID - 10.21037/jtd-23-1504 [doi]
PST - ppublish
SO  - J Thorac Dis. 2023 Nov 30;15(11):6265-6278. doi: 10.21037/jtd-23-1504. Epub 2023 
      Nov 27.