PMID- 38092165
OWN - NLM
STAT- MEDLINE
DCOM- 20240110
LR  - 20240116
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 349
DP  - 2024 Feb
TI  - DNA methylation reprogramming mediates transgenerational diabetogenic effect 
      induced by early-life p,p'-DDE exposure.
PG  - 140907
LID - S0045-6535(23)03177-6 [pii]
LID - 10.1016/j.chemosphere.2023.140907 [doi]
AB  - Increasing evidence shows that an adverse environment during the early fetal 
      development can affect the epigenetic modifications on a wide range of 
      diabetes-related genes, leading to an increased diabetic susceptibility in 
      adulthood or even in subsequent generations. 
      p,p'-Dichlorodiphenoxydichloroethylene (p,p'-DDE) is a break-down product of the 
      pesticide dichlorodiphenyltrichloroethane (DDT). p,p'-DDE has been associated 
      with various health concerns, such as diabetogenic effect. However, the precise 
      molecular mechanism remains unclear. In this study, p,p'-DDE was given by gavage 
      to pregnant rat dams from gestational day (GD) 8 to GD15 to generate male 
      germline to investiagate the transgenerational effects. We found that early-life 
      p,p'-DDE exposure increased the transgenerational diabetic susceptibility through 
      male germline inheritance. In utero exposure to p,p'-DDE altered the sperm DNA 
      methylome in F1 progeny, and a significant number of those differentially 
      methylated genes could be inherited by F2 progeny. Furthermore, early-life 
      p,p'-DDE exposure altered DNA methylation in glucose metabolic genes Gck and G6pc 
      in sperm and the methylation modification were also found in liver of the next 
      generation. Our study demonstrate that DNA methylation plays a critical role in 
      mediating transgenerational diabetogenic effect induced by early-life p,p'-DDE 
      exposure.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Wang, Shuo
AU  - Wang S
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China.
FAU - Wu, Jingjing
AU  - Wu J
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China.
FAU - Chen, Zhong
AU  - Chen Z
AD  - Center for Genomics, Loma Linda University School of Medicine, 11021 Campus 
      Street, Loma Linda, CA, 92350, USA.
FAU - Wu, Wei
AU  - Wu W
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China.
FAU - Lu, Liping
AU  - Lu L
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China.
FAU - Cheng, Yuzhou
AU  - Cheng Y
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China.
FAU - Li, Shuqi
AU  - Li S
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China.
FAU - Chen, Liangjing
AU  - Chen L
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China.
FAU - Tan, Xiaohua
AU  - Tan X
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China.
FAU - Yang, Lei
AU  - Yang L
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China.
FAU - Wang, Charles
AU  - Wang C
AD  - Center for Genomics, Loma Linda University School of Medicine, 11021 Campus 
      Street, Loma Linda, CA, 92350, USA.
FAU - Song, Yang
AU  - Song Y
AD  - School of Public Health, Hangzhou Normal University, 2318 Yuhangtang Road, 
      Hangzhou, China. Electronic address: sygp_0@163.com.
LA  - eng
PT  - Journal Article
DEP - 20231211
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - CIW5S16655 (DDT)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Male
MH  - Rats
MH  - Animals
MH  - *DNA Methylation
MH  - Dichlorodiphenyl Dichloroethylene/metabolism
MH  - Semen
MH  - DDT/metabolism
MH  - *Diabetes Mellitus
OTO - NOTNLM
OT  - DNA methylome
OT  - Diabetogenic effect
OT  - Sperm
OT  - Transgeneration
OT  - p,p'-DDE
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/14 00:42
MHDA- 2024/01/10 06:42
CRDT- 2023/12/13 19:26
PHST- 2023/07/18 00:00 [received]
PHST- 2023/11/18 00:00 [revised]
PHST- 2023/12/03 00:00 [accepted]
PHST- 2024/01/10 06:42 [medline]
PHST- 2023/12/14 00:42 [pubmed]
PHST- 2023/12/13 19:26 [entrez]
AID - S0045-6535(23)03177-6 [pii]
AID - 10.1016/j.chemosphere.2023.140907 [doi]
PST - ppublish
SO  - Chemosphere. 2024 Feb;349:140907. doi: 10.1016/j.chemosphere.2023.140907. Epub 
      2023 Dec 11.