PMID- 38093416
OWN - NLM
STAT- MEDLINE
DCOM- 20240126
LR  - 20240204
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 321
IP  - 1
DP  - 2024 Jan
TI  - Decoding immunogenic cell death from a dendritic cell perspective.
PG  - 350-370
LID - 10.1111/imr.13301 [doi]
AB  - Dendritic cells (DCs) are myeloid cells bridging the innate and adaptive immune 
      system. By cross-presenting tumor-associated antigens (TAAs) liberated upon 
      spontaneous or therapy-induced tumor cell death to T cells, DCs occupy a pivotal 
      position in the cancer immunity cycle. Over the last decades, the mechanisms 
      linking cancer cell death to DC maturation, have been the focus of intense 
      research. Growing evidence supports the concept that the mere transfer of TAAs 
      during the process of cell death is insufficient to drive immunogenic DC 
      maturation unless this process is coupled with the release of immunomodulatory 
      signals by dying cancer cells. Malignant cells succumbing to a regulated cell 
      death variant called immunogenic cell death (ICD), foster a proficient interface 
      with DCs, enabling their immunogenic maturation and engagement of adaptive 
      immunity against cancer. This property relies on the ability of ICD to exhibit 
      pathogen-mimicry hallmarks and orchestrate the emission of a spectrum of 
      constitutively present or de novo-induced danger signals, collectively known as 
      damage-associated molecular patterns (DAMPs). In this review, we discuss how DCs 
      perceive and decode danger signals emanating from malignant cells undergoing ICD 
      and provide an outlook of the major signaling and functional consequences of this 
      interaction for DCs and antitumor immunity.
CI  - (c) 2023 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.
FAU - Janssens, Sophie
AU  - Janssens S
AD  - Laboratory for ER Stress and Inflammation, Center for Inflammation Research, VIB, 
      Ghent, Belgium.
AD  - Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
FAU - Rennen, Sofie
AU  - Rennen S
AD  - Laboratory for ER Stress and Inflammation, Center for Inflammation Research, VIB, 
      Ghent, Belgium.
AD  - Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
FAU - Agostinis, Patrizia
AU  - Agostinis P
AUID- ORCID: 0000-0001-6167-8614
AD  - Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
LA  - eng
GR  - 01D02419/Bijzonder Onderzoeksfonds UGent/
GR  - 40007532/EOS MetaNiche consortium/
GR  - 30837538/EOS-DECODE consortium/
GR  - CoG 819314/ERC Co-G DC-RIDDLE/
GR  - G017521N/Fonds Wetenschappelijk Onderzoek/
GR  - G050622N/Fonds Wetenschappelijk Onderzoek/
GR  - G0A3320N/Fonds Wetenschappelijk Onderzoek/
GR  - iBOF/21/053/iBOF ATLANTIS network/
GR  - C14/21/095/KU Leuven InterAction consortium/
GR  - F/2022/2037/Stichting Tegen Kanker/
PT  - Journal Article
PT  - Review
DEP - 20231213
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Antigens, Neoplasm)
SB  - IM
MH  - Humans
MH  - *Immunogenic Cell Death
MH  - Dendritic Cells
MH  - Cell Death
MH  - *Neoplasms
MH  - Antigens, Neoplasm
MH  - Adaptive Immunity
OTO - NOTNLM
OT  - antitumor immunity
OT  - damage-associated molecular patterns
OT  - dendritic cells
OT  - immunogenic cell death
OT  - inflammation
EDAT- 2023/12/14 06:42
MHDA- 2024/01/26 06:43
CRDT- 2023/12/14 00:13
PHST- 2024/01/26 06:43 [medline]
PHST- 2023/12/14 06:42 [pubmed]
PHST- 2023/12/14 00:13 [entrez]
AID - 10.1111/imr.13301 [doi]
PST - ppublish
SO  - Immunol Rev. 2024 Jan;321(1):350-370. doi: 10.1111/imr.13301. Epub 2023 Dec 13.