PMID- 38094008
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231214
IS  - 2589-3610 (Electronic)
IS  - 1674-6384 (Print)
IS  - 1674-6384 (Linking)
VI  - 15
IP  - 4
DP  - 2023 Oct
TI  - Scutellarin alleviates liver injury in type 2 diabetic mellitus by suppressing 
      hepatocyte apoptosis in vitro and in vivo.
PG  - 542-548
LID - 10.1016/j.chmed.2023.03.007 [doi]
AB  - OBJECTIVE: Scutellarin is a primary active composition come from 
      Erigeron breviscapus. It is well known that scutellarin has anti-inflammatory and 
      antioxidant physiological functions. In this study, we detected the effects of 
      scutellarin on hepatocyte cell apoptosis in type 2 diabetes mellitus (T2DM) rats. 
      METHODS: Sprague Dawley (SD) (6-8 weeks, 160-180 g) rats were randomly divided 
      into six groups: control, model, scutellarin low-dose, medium-dose, high-dose 
      treatment, and rosiglitazone positive groups; with 10 SD rats in each group 
      (n = 10). The changes of biochemical factors in serum were detected by automatic 
      biochemical instrument, the pathological changes of liver tissue were detected by 
      hematoxylin and eosin (HE) staining, the apoptosis of liver tissue and cells was 
      detected by tissue staining and flow analyzer, and the expression of 
      apoptosis-related factors were determined by qPCR, Western blot and 
      immunohistochemistry in liver tissues or cells. RESULTS: The results showed that 
      scutellarin decreased the levels of fasting blood glucose, total cholesterol, 
      triglyceride, and low-density lipoprotein and increased the levels of 
      high-density lipoprotein. Meanwhile, scutellarin decreased the levels of alanine 
      transaminase (ALT) and aspartate transaminase (AST) and improved liver function. 
      In addition, scutellarin suppressed the secretion of interleukin-1 (IL-1), 
      interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and reduced hepatocyte 
      apoptosis. Furthermore, scutellarin inhibited the expression of cleaved 
      Caspase-3, Bax, and cytochrome C (Cyt-C) and promoted the expression of Bcl-2. 
      CONCLUSION: Scutellarin can inhibit the apoptotic pathway, thereby relieving 
      T2DM.
CI  - (c) 2023 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.
FAU - Fan, Xiaoming
AU  - Fan X
AD  - Department of Human Anatomy, School of Basic Medicine, Guilin Medical University, 
      Guilin 541004, China.
FAU - Wang, Yiyu
AU  - Wang Y
AD  - Department of Laboratory, The Affiliated Women's and Children's Hospital of 
      Chengdu Medical College, Chengdu 610045, China.
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Kunming Medical University, Kunming 650500, China.
FAU - Li, Xifan
AU  - Li X
AD  - Department of Human Anatomy, School of Basic Medicine, Guilin Medical University, 
      Guilin 541004, China.
FAU - Zhong, Taiqing
AU  - Zhong T
AD  - Department of Laboratory, The Affiliated Women's and Children's Hospital of 
      Chengdu Medical College, Chengdu 610045, China.
FAU - Cheng, Chunlan
AU  - Cheng C
AD  - Department of Laboratory, The Affiliated Women's and Children's Hospital of 
      Chengdu Medical College, Chengdu 610045, China.
FAU - Zhang, Yunfei
AU  - Zhang Y
AD  - Department of Physiology, School of Basic Medicine, Guilin Medical University, 
      Guilin 541004, China.
LA  - eng
PT  - Journal Article
DEP - 20230901
PL  - Singapore
TA  - Chin Herb Med
JT  - Chinese herbal medicines
JID - 101556727
PMC - PMC10715877
OTO - NOTNLM
OT  - apoptosis
OT  - hepatocyte cells
OT  - liver failure
OT  - scutellarin
OT  - type 2 diabetic mellitus
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/12/14 06:42
MHDA- 2023/12/14 06:43
PMCR- 2023/09/01
CRDT- 2023/12/14 04:07
PHST- 2022/11/01 00:00 [received]
PHST- 2023/01/18 00:00 [revised]
PHST- 2023/03/23 00:00 [accepted]
PHST- 2023/12/14 06:43 [medline]
PHST- 2023/12/14 06:42 [pubmed]
PHST- 2023/12/14 04:07 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - S1674-6384(23)00077-1 [pii]
AID - 10.1016/j.chmed.2023.03.007 [doi]
PST - epublish
SO  - Chin Herb Med. 2023 Sep 1;15(4):542-548. doi: 10.1016/j.chmed.2023.03.007. 
      eCollection 2023 Oct.