PMID- 38094032
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231214
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 11
IP  - 12
DP  - 2023 Dec
TI  - Analysis of adverse events with lumen apposing metal stents for drainage of 
      pancreatic fluid collections.
PG  - E1153-E1160
LID - 10.1055/a-2197-3731 [doi]
AB  - Background and study aims Innovations in endoscopic management of pancreatic 
      fluid collections (PFCs) using lumen apposing metal stents (LAMS) have rendered 
      it a preferred approach for drainage of PFCs. These advances have not come 
      without concern for adverse events (AEs). We present our experience with LAMS for 
      drainage of PFCs and analyze factors that contribute to LAMS-related AEs. 
      Patients and methods From November 2015 to October 2021, a retrospective analysis 
      was performed of patients undergoing endoscopic management of PFCs using LAMS. 
      All AEs were classified as either early (<48 hours) or late (>48 hours). 
      Univariate and multivariate analysis were performed using logistic regression to 
      assess the relationship between independent variables and AEs. Results A total of 
      119 patients with symptomatic PFCs underwent endoscopic drainage with LAMS. There 
      were 16 AEs (12.4%). These included systemic inflammatory response syndrome 
      (SIRS) (n=2), stent occlusion (n=5), bleeding (n=7), and stent migration (n=2). 
      Univariate analysis of risk of AEs showed that no variables approached 
      statistical significance. Of the seven patients who developed bleeding, five had 
      pseudoaneurysms following LAMS placement and underwent angioembolization by an 
      interventional radiologist. The average time to bleeding was 9.3 days (standard 
      deviation 7.3) with all bleeding events occurring within 3 weeks. In a 
      multivariate model, pseudocysts and presence of paracolic gutter extension were 
      associated with an increased risk of bleeding. Conclusions Endoscopists should be 
      aware of the risk factors for LAMS-related bleeding and tailor their drainage 
      strategy, including utilization of plastic stents for drainage of pseudocysts and 
      adherence to a strict imaging interval and follow-up protocol.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial-License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commercial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Pawa, Rishi
AU  - Pawa R
AUID- ORCID: 0000-0001-6452-2359
AD  - Gastroenterology, Wake Forest University School of Medicine, Winston-Salem, 
      United States. RINGGOLD: 12279
FAU - Dorrell, Robert
AU  - Dorrell R
AD  - Gastroenterology, Wake Forest University School of Medicine, Winston-Salem, 
      United States. RINGGOLD: 12279
FAU - Nguyen, Madison
AU  - Nguyen M
AD  - Department of Medicine, Virginia Commonwealth University, Richmond, United 
      States. RINGGOLD: 6889
FAU - Russell, Greg
AU  - Russell G
AD  - Biostatistics, Wake Forest University School of Medicine, Winston-Salem, United 
      States. RINGGOLD: 12279
FAU - Gilliam, John
AU  - Gilliam J
AD  - Gastroenterology, Wake Forest University School of Medicine, Winston-Salem, 
      United States. RINGGOLD: 12279
LA  - eng
PT  - Journal Article
DEP - 20231212
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC10715910
OTO - NOTNLM
OT  - Endoscopic ultrasonography
OT  - GI radiology
OT  - Intervention EUS
OT  - Pancreas
OT  - Quality and logistical aspects
COIS- Conflict of Interest Rishi Pawa is a consultant for Boston Scientific and Cook 
      Medical. The remaining authors have no conflict of interest to declare.
EDAT- 2023/12/14 06:41
MHDA- 2023/12/14 06:42
PMCR- 2023/12/01
CRDT- 2023/12/14 04:07
PHST- 2023/07/29 00:00 [received]
PHST- 2023/10/19 00:00 [accepted]
PHST- 2023/12/14 06:42 [medline]
PHST- 2023/12/14 06:41 [pubmed]
PHST- 2023/12/14 04:07 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - EIO-2023-07-3082-OA [pii]
AID - 10.1055/a-2197-3731 [doi]
PST - epublish
SO  - Endosc Int Open. 2023 Dec 12;11(12):E1153-E1160. doi: 10.1055/a-2197-3731. 
      eCollection 2023 Dec.