PMID- 38095090
OWN - NLM
STAT- MEDLINE
DCOM- 20240311
LR  - 20240311
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 39
IP  - 4
DP  - 2024 Apr
TI  - Curcumin attenuates diphenyl phosphate-induced apoptosis in GC-2spd(ts) cells 
      through activated autophagy via the Nrf2/P53 pathway.
PG  - 2032-2042
LID - 10.1002/tox.24092 [doi]
AB  - Diphenyl phosphate (DPhP) is one of the frequently used derivatives of aryl 
      phosphate esters and is used as a plasticizer in industrial production. Like 
      other plasticizers, DPhP is not chemically bound and can easily escape into the 
      environment, thereby affecting human health. DPhP has been associated with 
      developmental toxicity, reproductive toxicity, neurodevelopmental toxicity, and 
      interference with thyroid homeostasis. However, understanding of the underlying 
      mechanism of DPhP on the reproductive toxicity of GC-2spd(ts) cells remains 
      limited. For the first time, we investigated the effect of DPhP on GC-2spd(ts) 
      cell apoptosis. By decreasing nuclear factor erythroid-derived 2-related factor 
      (Nrf2)/p53 signaling, DPhP inhibited autophagy and promoted apoptosis. DPhP 
      reduced total antioxidant capacity and nuclear Nrf2 and its downstream target 
      gene expression. In addition, we investigated the protective effects of Curcumin 
      (Cur) against DPhP toxicity. Cur attenuated the DPhP-induced rise in p53 
      expression while increasing Nrf2 expression. Cur inhibited DPhP-induced apoptosis 
      in GC-2spd(ts) cells by activating autophagy via Nrf2/p53 signaling. In 
      conclusion, our study provides new insights into the reproductive toxicity 
      hazards of DPhP and demonstrates that Cur is an important therapeutic agent for 
      alleviating DPhP-induced reproductive toxicity by regulating Nrf2/p53 signaling.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Wei, Lai
AU  - Wei L
AD  - Department of Health Toxicology, Xiangya School of Public Health, Central South 
      University, Changsha, People's Republic of China.
FAU - Li, Siwen
AU  - Li S
AD  - Department of Health Toxicology, Xiangya School of Public Health, Central South 
      University, Changsha, People's Republic of China.
FAU - Ma, Yu
AU  - Ma Y
AD  - Department of Health Toxicology, Xiangya School of Public Health, Central South 
      University, Changsha, People's Republic of China.
FAU - Ye, Shuzi
AU  - Ye S
AD  - Department of Health Toxicology, Xiangya School of Public Health, Central South 
      University, Changsha, People's Republic of China.
FAU - Yuan, Yu
AU  - Yuan Y
AD  - Department of Health Toxicology, Xiangya School of Public Health, Central South 
      University, Changsha, People's Republic of China.
FAU - Zeng, Yuan
AU  - Zeng Y
AD  - Department of Health Toxicology, Xiangya School of Public Health, Central South 
      University, Changsha, People's Republic of China.
FAU - Raza, Tausif
AU  - Raza T
AD  - Department of Health Toxicology, Xiangya School of Public Health, Central South 
      University, Changsha, People's Republic of China.
FAU - Xiao, Fang
AU  - Xiao F
AUID- ORCID: 0000-0002-6814-1227
AD  - Department of Health Toxicology, Xiangya School of Public Health, Central South 
      University, Changsha, People's Republic of China.
LA  - eng
GR  - CX20230333/Postgraduate Independent Exploration and Innovation Project of Hunan 
      Province, China/
GR  - 2023ZZTS0261/Postgraduate Independent Exploration and Innovation Project of 
      Central South University, China/
PT  - Journal Article
DEP - 20231214
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - IT942ZTH98 (Curcumin)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 2L9GJK6MGN (diphenyl)
RN  - 0 (Phosphates)
RN  - 0 (Plasticizers)
RN  - 0 (Biphenyl Compounds)
SB  - IM
MH  - Humans
MH  - *Curcumin/pharmacology
MH  - NF-E2-Related Factor 2/metabolism
MH  - Tumor Suppressor Protein p53/metabolism
MH  - Phosphates/metabolism/pharmacology
MH  - Apoptosis
MH  - Plasticizers
MH  - Autophagy
MH  - *Biphenyl Compounds
OTO - NOTNLM
OT  - apoptosis
OT  - autophagy
OT  - curcumin (Cur)
OT  - diphenyl phosphate (DPhP)
OT  - nuclear factor erythroid-derived 2-related factor (Nrf2)
OT  - reproductive toxicity
EDAT- 2023/12/14 06:42
MHDA- 2024/03/11 06:42
CRDT- 2023/12/14 05:34
PHST- 2023/11/19 00:00 [revised]
PHST- 2023/10/05 00:00 [received]
PHST- 2023/12/01 00:00 [accepted]
PHST- 2024/03/11 06:42 [medline]
PHST- 2023/12/14 06:42 [pubmed]
PHST- 2023/12/14 05:34 [entrez]
AID - 10.1002/tox.24092 [doi]
PST - ppublish
SO  - Environ Toxicol. 2024 Apr;39(4):2032-2042. doi: 10.1002/tox.24092. Epub 2023 Dec 
      14.