PMID- 38098894
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231216
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 11
DP  - 2023 Nov
TI  - Acute Hepatitis E-Associated Guillain-Barre Syndrome.
PG  - e48778
LID - 10.7759/cureus.48778 [doi]
LID - e48778
AB  - Guillain-Barre syndrome (GBS) is a rare autoimmune disorder of the peripheral 
      nervous system that causes progressive weakness and sensory disturbances, usually 
      following an infection or immunization. It has been associated with multiple 
      causes, including bacterial and viral infections. Hepatitis E virus (HEV) is a 
      common cause of acute viral hepatitis that can rarely develop neurological 
      complications. We report a case of a 72-year-old man who developed GBS secondary 
      to an acute HEV infection. He presented with numbness and weakness of the lower 
      limbs that rapidly evolved into respiratory failure requiring mechanical 
      ventilation and intravenous immunoglobulin therapy (IVIg). This case adds to the 
      literature on the association between HEV infection and GBS and the importance of 
      early detection of this rapidly progressive condition.
CI  - Copyright (c) 2023, Rodrigues et al.
FAU - Rodrigues, Ricardo A
AU  - Rodrigues RA
AD  - Internal Medicine, University Hospital Center of Coimbra, Coimbra, PRT.
FAU - Sequeira, Miguel
AU  - Sequeira M
AD  - Intensive Medicine, University Hospital Center of Coimbra, Coimbra, PRT.
FAU - Barros, Francisco
AU  - Barros F
AD  - Neurology, University Hospital Center of Coimbra, Coimbra, PRT.
FAU - Alves, Telma
AU  - Alves T
AD  - Internal Medicine, University Hospital Center of Coimbra, Coimbra, PRT.
FAU - Goncalves, Joao
AU  - Goncalves J
AD  - Internal Medicine, University Hospital Center of Coimbra, Coimbra, PRT.
LA  - eng
PT  - Case Reports
DEP - 20231114
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10719760
OTO - NOTNLM
OT  - acute viral hepatitis
OT  - auto-immune
OT  - demyelinating polyneuropathy
OT  - guillain barre's syndrome (gbs)
OT  - hepatitis e virus
OT  - hev
OT  - polyneuropathy
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/12/15 06:42
MHDA- 2023/12/15 06:43
PMCR- 2023/11/14
CRDT- 2023/12/15 03:56
PHST- 2023/11/13 00:00 [accepted]
PHST- 2023/12/15 06:43 [medline]
PHST- 2023/12/15 06:42 [pubmed]
PHST- 2023/12/15 03:56 [entrez]
PHST- 2023/11/14 00:00 [pmc-release]
AID - 10.7759/cureus.48778 [doi]
PST - epublish
SO  - Cureus. 2023 Nov 14;15(11):e48778. doi: 10.7759/cureus.48778. eCollection 2023 
      Nov.