PMID- 38101165
OWN - NLM
STAT- MEDLINE
DCOM- 20240110
LR  - 20240116
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 82
DP  - 2024 Mar
TI  - The relationship between plasma nickel concentrations and type 2 diabetes 
      mellitus risk: A protective effect within a specific range.
PG  - 127362
LID - S0946-672X(23)00238-9 [pii]
LID - 10.1016/j.jtemb.2023.127362 [doi]
AB  - BACKGROUND: Nickel is considered an essential nutrient for certain microbial, 
      plant, and animal species, but its role in human health remains controversial. 
      Some studies have reported the relationship between nickel and type 2 diabetes 
      mellitus (T2DM), but the results are not consistent and the mechanism is not 
      clear, which needs further exploration. AIM: To investigate the possible 
      correlation between nickel and T2DM. METHODS: We conducted a case-control study 
      of 192 patients with T2DM and 189 healthy controls at a hospital in central 
      China. Plasma concentrations of nickel and six other trace elements were measured 
      with inductively coupled plasma mass spectrometry. Logistic regression models, 
      restricted cubic spline models (RCS), and Bayesian kernel machine regression 
      (BKMR) were used to evaluate the relationship between plasma nickel and T2DM and 
      its metabolic risk factors, as well as the presence or absence of interactions 
      between nickel and other elements. RESULTS: The T2DM group exhibited considerably 
      lower plasma nickel levels than the control group (P < 0.001). Whether using a 
      crude or adjusted model, logistic regression analysis finds a negative 
      correlation between nickel levels and the risk of T2DM (P trend < 0.001). 
      According to the RCS, the risk of T2DM reduces with rising nickel levels when the 
      value is below 6.1 mug/L; nickel has a negative linear correlation with fasting 
      plasma glucose (FPG), an inverse U-shaped connection with superoxide dismutase 
      (SOD), and a positive linear correlation with malondialdehyde (MDA) (all P 
      overall < 0.05). The plasma nickel concentration was positively correlated with 
      zinc, vanadium, and chromium (r = 0.23, 0.11, and 0.19, respectively; all 
      P < 0.05) and negatively correlated with copper (r = - 0.11, P < 0.05). In the 
      BKMR model, interactions of nickel with zinc on T2DM and SOD, nickel with 
      chromium on T2DM and homeostasis model assessment of beta cell (HOMA-beta), and nickel 
      with copper on FPG, homeostasis model assessment of insulin (HOMA-IR), and MDA 
      were observed. CONCLUSION: Nickel may have a dual effect on the risk of T2DM, 
      with a protective range of less than 6.1 mug/L. Potential interactions between 
      nickel, copper, zinc, and chromium existed in their associations with T2DM and 
      its metabolic risk factors.
CI  - Copyright (c) 2023 Elsevier GmbH. All rights reserved.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - School of Public Health, Hubei University of Medicine, Shiyan 442000, China.
FAU - Cai, Junwei
AU  - Cai J
AD  - Department of Endocrinology, Taihe Hospital, Shiyan 442000, China.
FAU - Yao, Zijun
AU  - Yao Z
AD  - School of Public Health, Hubei University of Medicine, Shiyan 442000, China.
FAU - Zhang, Han
AU  - Zhang H
AD  - School of Public Health, Hubei University of Medicine, Shiyan 442000, China.
FAU - Wang, Zhen
AU  - Wang Z
AD  - School of Public Health, Hubei University of Medicine, Shiyan 442000, China.
FAU - Lei, Jinlin
AU  - Lei J
AD  - School of Public Health, Hubei University of Medicine, Shiyan 442000, China.
FAU - Guo, Huailan
AU  - Guo H
AD  - School of Public Health, Hubei University of Medicine, Shiyan 442000, China; 
      Research Center of Environment and Health of South-to-North Water Diversion Area, 
      Hubei University of Medicine, Shiyan 442000, China. Electronic address: 
      ghlhbmu@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20231211
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - 7OV03QG267 (Nickel)
RN  - 789U1901C5 (Copper)
RN  - J41CSQ7QDS (Zinc)
RN  - 0R0008Q3JB (Chromium)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Humans
MH  - Nickel
MH  - Copper
MH  - *Diabetes Mellitus, Type 2
MH  - Case-Control Studies
MH  - Bayes Theorem
MH  - Zinc
MH  - *Insulin Resistance
MH  - Chromium
MH  - Superoxide Dismutase
MH  - Blood Glucose/analysis
OTO - NOTNLM
OT  - BKMR
OT  - Interaction
OT  - Nickel
OT  - Trace element
OT  - Type 2 diabetes
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/16 11:42
MHDA- 2024/01/10 06:41
CRDT- 2023/12/15 18:12
PHST- 2023/09/21 00:00 [received]
PHST- 2023/11/17 00:00 [revised]
PHST- 2023/12/09 00:00 [accepted]
PHST- 2024/01/10 06:41 [medline]
PHST- 2023/12/16 11:42 [pubmed]
PHST- 2023/12/15 18:12 [entrez]
AID - S0946-672X(23)00238-9 [pii]
AID - 10.1016/j.jtemb.2023.127362 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2024 Mar;82:127362. doi: 10.1016/j.jtemb.2023.127362. Epub 
      2023 Dec 11.