PMID- 38102167
OWN - NLM
STAT- MEDLINE
DCOM- 20231218
LR  - 20231227
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Dec 15
TI  - The effect of donor against recipient one-way HLA mismatch on liver 
      transplantation outcomes from a multicenter registry analysis.
PG  - 22296
LID - 10.1038/s41598-023-49178-y [doi]
LID - 22296
AB  - Donor against recipient one-way Human leukocyte antigen (HLA) mismatch (D --> R 
      one-way HLA MM) seemed strongly associated with graft-versus-host disease (GVHD). 
      The aim of this study is to investigate the relevance of D --> R one-way HLA MM in 
      outcome of liver transplantation (LT). We retrospectively analyzed 2670 patients 
      in Korean Organ Transplantation Registry database between April 2014 and December 
      2020. The patients were categorized into two groups whether D --> R one-way HLA MM 
      or not and evaluated the outcomes of LT between the two groups. 18 patients were 
      found to be D --> R one-way HLA MM. The incidence of GVHD (0.3% vs. 22.2%, 
      p < 0.001) and mortality rate (11.6% vs. 38.9%, p = 0.003) was much higher in 
      D --> R one-way HLA MM group. D --> R one-way HLA MM at 3 loci was seemed to be 
      strongly associated with the incidence of GVHD (OR 163.3, p < 0.001), and found 
      to be the strongest risk factor for patient death (HR 12.75, p < 0.001). Patients 
      with D --> R one-way HLA MM at 3 loci showed significantly lower overall survival 
      (p < 0.001) but there were no significant differences in rejection-free survival 
      and death-censored graft survival. D --> R one-way HLA MM at 3 loci not only 
      affects the overall survival of LT patients but also the incidence of GVHD.
CI  - (c) 2023. The Author(s).
FAU - Park, Sunghae
AU  - Park S
AD  - Department of Surgery, Samsung Medical Center, Sungkyunkwan University, School of 
      Medicine, 50 Irwon-Dong, Gangnam-gu, Seoul, 135-710, Korea.
FAU - Choi, Young Rok
AU  - Choi YR
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul 
      National University Hospital, Seoul, Korea.
FAU - Joo, Dong Jin
AU  - Joo DJ
AD  - Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
FAU - You, Young Kyoung
AU  - You YK
AD  - Department of Surgery, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Kim, Bong-Wan
AU  - Kim BW
AD  - Department of Liver Transplantation and Hepatobiliary Surgery, Ajou University 
      School of Medicine, Suwon, Korea.
FAU - Nah, Yang Won
AU  - Nah YW
AD  - Department of Surgery, Ulsan University Hospital, University of Ulsan College of 
      Medicine, Ulsan, Korea.
FAU - Cho, Jai Young
AU  - Cho JY
AD  - Department of Surgery, Seoul National University Bundang Hospital, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Kim, Tae-Seok
AU  - Kim TS
AD  - Department of Surgery, Dongsan Medical Center, Keimyung University School of 
      Medicine, Daegu, Korea.
FAU - Hong, Geun
AU  - Hong G
AD  - Department of Surgery, Ewha Womans University Medical College, Seoul, Korea.
FAU - Ju, Man Ki
AU  - Ju MK
AD  - Department of Surgery, Yonsei University Gangnam Severance Hospital, Seoul, 
      Korea.
FAU - Suh, Suk-Won
AU  - Suh SW
AD  - Department of Surgery, College of Medicine, Chung-Ang University, Seoul, Korea.
FAU - Yang, Jae Do
AU  - Yang JD
AD  - Department of Surgery, Jeonbuk National University Hospital, Jeonju, Korea.
FAU - Park, Pyoung Jae
AU  - Park PJ
AD  - Department of Surgery, Korea University Guro Hospital, Korea University College 
      of Medicine, Seoul, Korea.
FAU - Jeong, Jaehong
AU  - Jeong J
AD  - Department of Surgery, School of Medicine, Soonchunhyang University, Bucheon, 
      Korea.
FAU - Moon, Ju Ik
AU  - Moon JI
AD  - Department of Surgery, Konyang University Hospital, Daejeon, Korea.
FAU - Kim, Dong-Sik
AU  - Kim DS
AUID- ORCID: 0000-0002-0608-1580
AD  - Department of Surgery, Korea University College of Medicine, Seoul, Korea. 
      kimds1@korea.ac.kr.
FAU - Rhu, Jinsoo
AU  - Rhu J
AUID- ORCID: 0000-0001-9809-8525
AD  - Department of Surgery, Samsung Medical Center, Sungkyunkwan University, School of 
      Medicine, 50 Irwon-Dong, Gangnam-gu, Seoul, 135-710, Korea. jsrrules@gmail.com.
CN  - Korean Organ Transplantation Registry Study Group
LA  - eng
GR  - 2014-ER6301-00/Korea Centers for Disease Control and Prevention,South Korea/
GR  - 2014-ER6301-01/Korea Centers for Disease Control and Prevention,South Korea/
GR  - 2014-ER6301-02/Korea Centers for Disease Control and Prevention,South Korea/
GR  - 2017-ER6301-00/Korea Centers for Disease Control and Prevention,South Korea/
GR  - 2017-ER6301-01/Korea Centers for Disease Control and Prevention,South Korea/
GR  - 2017-ER6301-02/Korea Centers for Disease Control and Prevention,South Korea/
GR  - 2020-ER7201-00/Korea Centers for Disease Control and Prevention,South Korea/
PT  - Journal Article
PT  - Multicenter Study
DEP - 20231215
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Humans
MH  - *Liver Transplantation/adverse effects
MH  - Retrospective Studies
MH  - Histocompatibility Testing
MH  - HLA Antigens
MH  - Histocompatibility Antigens Class I
MH  - *Graft vs Host Disease
MH  - Histocompatibility Antigens Class II
PMC - PMC10724161
COIS- The authors declare no competing interests.
EDAT- 2023/12/16 11:43
MHDA- 2023/12/18 06:41
PMCR- 2023/12/15
CRDT- 2023/12/15 23:26
PHST- 2023/01/29 00:00 [received]
PHST- 2023/12/05 00:00 [accepted]
PHST- 2023/12/18 06:41 [medline]
PHST- 2023/12/16 11:43 [pubmed]
PHST- 2023/12/15 23:26 [entrez]
PHST- 2023/12/15 00:00 [pmc-release]
AID - 10.1038/s41598-023-49178-y [pii]
AID - 49178 [pii]
AID - 10.1038/s41598-023-49178-y [doi]
PST - epublish
SO  - Sci Rep. 2023 Dec 15;13(1):22296. doi: 10.1038/s41598-023-49178-y.