PMID- 38103851
OWN - NLM
STAT- MEDLINE
DCOM- 20240115
LR  - 20240115
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 553
DP  - 2024 Jan 15
TI  - Thrombin generation and all-cause mortality in The Brazilian Longitudinal Study 
      of Adult Health (ELSA-Brasil).
PG  - 117712
LID - S0009-8981(23)00514-4 [pii]
LID - 10.1016/j.cca.2023.117712 [doi]
AB  - INTRODUCTION: Thrombin generation assay (TGA) is a laboratory method that 
      provides the global evaluation of hemostasis. The association between thrombin 
      generation and all-cause mortality is poorly investigated and results are 
      contradictory. This study evaluated whether TGA parameters are associated with 
      all-cause mortality in a prospective cohort. METHODS: This study was conducted in 
      2,588 participants enrolled at baseline of the Brazilian Longitudinal Study of 
      Adult Health (ELSA-Brasil). TGA was performed using the Calibrated Automated 
      Thrombogram (CAT) method, and its parameters lagtime, time-to-peak, peak, 
      Endogenous Thrombin Potential (ETP) and normalized ETP (nETP) were evaluated 
      according to the reference interval (RI). The association between TGA parameters 
      and all-cause mortality was estimated by Cox regression and adjusted for 
      confounders. RESULTS: The mean follow-up time was 6.6 +/- 2.7 years and 85 deaths 
      occurred. After adjustment, time-to-peak values above the RI at low and high 
      tissue factor (TF) concentrations were associated with higher risk of death 
      [HR = 2.45 (95 % CI: 1.17-5.13) and HR = 2.24 (95 % CI: 1.02-4.93), respectively] 
      and nETP and peak values below RI at high TF concentration were associated with 
      higher risk of death [HR = 3.85 (95 % CI: 1.39-10.68) and HR = 2.56 (95 % CI: 
      1.17-5.61), respectively]. CONCLUSIONS: Delayed thrombin generation was 
      associated with higher risk of all-cause mortality.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Goncalves Resende Ferreira, Leticia
AU  - Goncalves Resende Ferreira L
AD  - Universidade Federal de Sao Joao del-Rei, Campus Centro Oeste, Brazil.
FAU - Maria Barreto, Sandhi
AU  - Maria Barreto S
AD  - Department of Preventive Medicine, School of Medicine, Universidade Federal de 
      Minas Gerais (UFMG), Belo Horizonte, Brazil.
FAU - Bicalho Maluf, Chams
AU  - Bicalho Maluf C
AD  - Department of Clinical Pathology, School of Medicine, Universidade Federal de 
      Minas Gerais (UFMG), Belo Horizonte, Brazil.
FAU - Luiz Pinho Ribeiro, Antonio
AU  - Luiz Pinho Ribeiro A
AD  - Department of Internal Medicine, School of Medicine, and Telehealth Center and 
      Cardiology Service, Hospital das Clinicas, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - das Gracas Carvalho, Maria
AU  - das Gracas Carvalho M
AD  - Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, 
      Universidade Federal de Minas Gerais, Brazil.
FAU - Carvalho Figueiredo, Roberta
AU  - Carvalho Figueiredo R
AD  - Universidade Federal de Sao Joao del-Rei, Campus Centro Oeste, Brazil. Electronic 
      address: robertafigueiredo@ufsj.edu.br.
FAU - Romana Alves Rios, Danyelle
AU  - Romana Alves Rios D
AD  - Universidade Federal de Sao Joao del-Rei, Campus Centro Oeste, Brazil. Electronic 
      address: danyelleromana@ufsj.edu.br.
LA  - eng
PT  - Journal Article
DEP - 20231215
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Thrombin
MH  - Blood Coagulation Tests
MH  - Brazil
MH  - Prospective Studies
MH  - Longitudinal Studies
OTO - NOTNLM
OT  - Adult
OT  - All-cause mortality
OT  - Blood Coagulation Tests
OT  - Calibrated automated thrombogram
OT  - Cohort Studies
OT  - Thrombin generation
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/17 09:45
MHDA- 2024/01/15 12:43
CRDT- 2023/12/16 19:30
PHST- 2023/09/19 00:00 [received]
PHST- 2023/12/11 00:00 [revised]
PHST- 2023/12/11 00:00 [accepted]
PHST- 2024/01/15 12:43 [medline]
PHST- 2023/12/17 09:45 [pubmed]
PHST- 2023/12/16 19:30 [entrez]
AID - S0009-8981(23)00514-4 [pii]
AID - 10.1016/j.cca.2023.117712 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2024 Jan 15;553:117712. doi: 10.1016/j.cca.2023.117712. Epub 2023 
      Dec 15.