PMID- 38104318 OWN - NLM STAT- MEDLINE DCOM- 20240228 LR - 20240228 IS - 1097-6817 (Electronic) IS - 0194-5998 (Linking) VI - 170 IP - 3 DP - 2024 Mar TI - Long-Term Efficacy and Safety of Subcutaneous Immunotherapy in Monosensitized and Polysensitized Children With Allergic Rhinitis. PG - 919-927 LID - 10.1002/ohn.614 [doi] AB - OBJECTIVE: To evaluate the efficacy and safety of dust mite subcutaneous immunotherapy (SCIT) in monosensitized and polysensitized children with allergic rhinitis (AR). STUDY DESIGN: Prospective cohort study. SETTING: Tertiary referral center. METHODS: One hundred thirty children were enrolled and categorized into 2 groups: monosensitized to only dust mites and polysensitized to at least 1 additional allergen beyond dust mites. All patients received SCIT targeting dust mites for 3 years, followed by a 5-year monitoring period. The Total Nasal Symptom Score (TNSS), Symptom and Medication Score (SMS), Visual Analogue Scale (VAS), and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) were assessed before SCIT (T0); at 1 (T1) and 2 (T2) years of SCIT; immediately after SCIT (T3); and 2 years post-SCIT (T5). Safety was assessed based on adverse events (AEs). RESULTS: Fifty-one monosensitized and 50 polysensitized children completed the study. At T3, 47 monosensitized and 46 polysensitized children were effectively treated, with no significant between-group difference in efficacy (P > .05). The TNSS, SMS, VAS scores, and RQLQ score were significantly lower at T1, T2, T3, and T5 than at T0 in both groups (P < .05). The differences in the TNSS, SMS, VAS score, and RQLQ score between the 2 groups were nonsignificant at T0, T1, T2, and T3 (P > .05), but significant at T5 (P < .05). No serious AEs were reported. CONCLUSION: Monosensitized and polysensitized children exhibited similar beneficial efficacy and safety after 3 years of dust mite SCIT. Monosensitized children derived more benefits 2 years after discontinuation. CI - (c) 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation. FAU - Yuan, Xuan AU - Yuan X AD - Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China. FAU - Xie, Shaobing AU - Xie S AD - Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China. FAU - Zhang, Hua AU - Zhang H AD - Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China. FAU - Zhang, Junyi AU - Zhang J AD - Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China. FAU - Fan, Ruohao AU - Fan R AD - Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China. FAU - Jiang, Weihong AU - Jiang W AUID- ORCID: 0000-0002-3854-8923 AD - Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China. FAU - Xie, Zhihai AU - Xie Z AUID- ORCID: 0000-0001-7189-3510 AD - Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China. AD - Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China. LA - eng PT - Journal Article DEP - 20231217 PL - England TA - Otolaryngol Head Neck Surg JT - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JID - 8508176 RN - 0 (Antigens, Dermatophagoides) RN - 0 (Allergens) RN - 0 (Dust) SB - IM MH - Child MH - Animals MH - Humans MH - Prospective Studies MH - Quality of Life MH - *Sublingual Immunotherapy/adverse effects MH - Treatment Outcome MH - Antigens, Dermatophagoides/therapeutic use MH - *Rhinitis, Allergic/drug therapy MH - Allergens MH - Pyroglyphidae MH - Immunotherapy MH - Dust OTO - NOTNLM OT - allergic rhinitis OT - efficacy OT - monosensitized OT - polysensitized OT - subcutaneous immunotherapy EDAT- 2023/12/17 18:42 MHDA- 2024/02/28 06:44 CRDT- 2023/12/17 12:52 PHST- 2023/10/05 00:00 [revised] PHST- 2023/07/02 00:00 [received] PHST- 2023/11/11 00:00 [accepted] PHST- 2024/02/28 06:44 [medline] PHST- 2023/12/17 18:42 [pubmed] PHST- 2023/12/17 12:52 [entrez] AID - 10.1002/ohn.614 [doi] PST - ppublish SO - Otolaryngol Head Neck Surg. 2024 Mar;170(3):919-927. doi: 10.1002/ohn.614. Epub 2023 Dec 17.