PMID- 38104984
OWN - NLM
STAT- MEDLINE
DCOM- 20240126
LR  - 20240204
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 47
IP  - 1
DP  - 2024 Jan 24
TI  - Development of a New Jelly Coating Technology (Oral Jelly Coating) to Improve 
      Prescribed Medication Adherence.
PG  - 259-271
LID - 10.1248/bpb.b23-00625 [doi]
AB  - Tablets are the most commonly prescribed dosage form for oral drug 
      administration. Historically, improvement of medication adherence of tablets has 
      been facilitated through, for example, the use of smaller tablets, distinctive 
      shaped tablets and sugar-coated tablets. In addition, new formulation 
      technologies such as orally disintegrating tablets (OD tablets), micro 
      tablet-type granules, jellies, and film formulations are making it possible to 
      create more easily ingested dosage forms. We have developed a new oral jelly 
      coating formulation that can be applied to any sized tablet without reducing the 
      size of the formulation. It was found that this new jelly layer formed on the 
      tablet surface improved the tablet's slipperiness with an appropriate amount of 
      water, while ensuring no change in the dissolution profile. In addition, the 
      jelly layer was ensured storage stability over time without affecting the 
      dissolution profile. Although further studies are needed, this coating technology 
      can quickly change the tablet surface to a jelly-like state after the tablet is 
      taken, giving the tablet the same slipperiness as if it were taken in jelly, 
      making it easier to pass through the pharynx, and thus improving medication 
      adherence.
FAU - Yamashita, Junya
AU  - Yamashita J
AD  - Kyowa Pharmaceutical Industry Co., Ltd.
FAU - Asai, Shota
AU  - Asai S
AD  - Kyowa Pharmaceutical Industry Co., Ltd.
FAU - Shingaki, Hiroki
AU  - Shingaki H
AD  - Kyowa Pharmaceutical Industry Co., Ltd.
FAU - Hayakawa, Masakane
AU  - Hayakawa M
AD  - Kyowa Pharmaceutical Industry Co., Ltd.
LA  - eng
PT  - Journal Article
DEP - 20231216
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Tablets)
SB  - IM
MH  - Tablets
MH  - *Food
MH  - *Technology
MH  - Administration, Oral
MH  - Solubility
OTO - NOTNLM
OT  - film coating
OT  - medication adherence
OT  - oral jelly coating
OT  - slipperiness
EDAT- 2023/12/18 00:42
MHDA- 2024/01/26 06:43
CRDT- 2023/12/17 20:23
PHST- 2024/01/26 06:43 [medline]
PHST- 2023/12/18 00:42 [pubmed]
PHST- 2023/12/17 20:23 [entrez]
AID - 10.1248/bpb.b23-00625 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2024 Jan 24;47(1):259-271. doi: 10.1248/bpb.b23-00625. Epub 2023 
      Dec 16.