PMID- 38105976
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240416
DP  - 2023 Dec 7
TI  - Normative Values of Echocardiographic Chamber Size and Function in Older Healthy 
      Adults: The Multi-Ethnic Study of Atherosclerosis.
LID - 2023.12.05.23299572 [pii]
LID - 10.1101/2023.12.05.23299572 [doi]
AB  - BACKGROUND: Echocardiographic (2DE) thresholds indicating disease or impaired 
      functional status compared to normal physiologic aging in individuals >/= 65 years 
      are not clearly defined. In the present study, we sought to establish standard 
      values for 2DE parameters related to chamber size and function in older adults 
      without cardiopulmonary or cardiometabolic conditions. METHODS: In this 
      cross-sectional study of 3032 individuals who underwent 2DE at Exam 6 in the 
      Multi-Ethnic Study of Atherosclerosis (MESA), 608 participants fulfilled our 
      inclusion criteria, with normative values defined as the mean value +/- 1.96 
      standard deviations and compared across sex and race/ethnicity. Functional status 
      measures included NT-proBNP, 6-minute walk distance [6MWD], and Kansas City 
      Cardiomyopathy Questionnaire [KCCQ]. Prognostic performance using MESA cutoffs 
      was compared to established guideline cutoffs using time-to-event analysis. 
      RESULTS: Participants meeting our inclusion criteria (69.5 +/- 7.0 years, 46.2% 
      male, 47.5% White) had lower NT-proBNP, higher 6MWD, and higher (better) KCCQ 
      summary values. Women had significantly smaller chamber sizes and better 
      biventricular systolic function. White participants had the largest chamber 
      dimensions, while Chinese participants had the smallest, even after adjustment 
      for body size. Current guidelines identified 81.6% of healthy older adults in 
      MESA as having cardiac abnormalities. CONCLUSIONS: Among a large, diverse group 
      of healthy older adults, we found significant differences in cardiac structure 
      and function across sexes and races/ethnicities, which may signal sex-specific 
      cardiac remodeling with advancing age. It is crucial for existing guidelines to 
      consider the observed and clinically significant differences in cardiac structure 
      and function associated with healthy aging. Our study highlights that existing 
      guidelines, which grade abnormalities in echocardiographic cardiac chamber size 
      and function based on younger individuals, may not adequately address the 
      anticipated changes associated with normal aging.
FAU - Mukherjee, Monica
AU  - Mukherjee M
AUID- ORCID: 0000-0001-6088-0773
FAU - Strom, Jordan B
AU  - Strom JB
AUID- ORCID: 0000-0002-6592-6141
FAU - Afilalo, Jonathan
AU  - Afilalo J
AUID- ORCID: 0000-0003-0555-4937
FAU - Hu, Mo
AU  - Hu M
FAU - Beussink-Nelson, Lauren
AU  - Beussink-Nelson L
AUID- ORCID: 0000-0002-7260-6912
FAU - Kim, Jiwon
AU  - Kim J
AUID- ORCID: 0000-0002-8420-8604
FAU - Addetia, Karima
AU  - Addetia K
FAU - Bertoni, Alain
AU  - Bertoni A
AUID- ORCID: 0000-0002-7503-6273
FAU - Gottdiener, John
AU  - Gottdiener J
FAU - Michos, Erin D
AU  - Michos ED
AUID- ORCID: 0000-0002-5547-5084
FAU - Gardin, Julius M
AU  - Gardin JM
FAU - Shah, Sanjiv J
AU  - Shah SJ
AUID- ORCID: 0000-0002-5655-8201
FAU - Freed, Benjamin H
AU  - Freed BH
LA  - eng
PT  - Preprint
DEP - 20231207
PL  - United States
TA  - medRxiv
JT  - medRxiv : the preprint server for health sciences
JID - 101767986
UIN - J Am Heart Assoc. 2024 Apr 3;:e034029. PMID: 38567667
PMC - PMC10723504
EDAT- 2023/12/18 06:42
MHDA- 2023/12/18 06:43
PMCR- 2023/12/15
CRDT- 2023/12/18 04:30
PHST- 2023/12/18 06:43 [medline]
PHST- 2023/12/18 06:42 [pubmed]
PHST- 2023/12/18 04:30 [entrez]
PHST- 2023/12/15 00:00 [pmc-release]
AID - 2023.12.05.23299572 [pii]
AID - 10.1101/2023.12.05.23299572 [doi]
PST - epublish
SO  - medRxiv [Preprint]. 2023 Dec 7:2023.12.05.23299572. doi: 
      10.1101/2023.12.05.23299572.