PMID- 38108108
OWN - NLM
STAT- MEDLINE
DCOM- 20240326
LR  - 20240326
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Linking)
VI  - 76
IP  - 4
DP  - 2024 Apr
TI  - Associations Between Thiazolidinediones Use and Incidence of Rheumatoid 
      Arthritis: A Retrospective Population-Based Cohort Study.
PG  - 486-496
LID - 10.1002/acr.25277 [doi]
AB  - OBJECTIVE: Preclinical studies suggest that thiazolidinediones (TZDs) may have a 
      protective effect on rheumatoid arthritis (RA), but evidence from 
      population-based studies is scarce. This study aimed to assess the association 
      between use of TZDs and incidence of RA in a retrospective cohort of patients 
      with type 2 diabetes mellitus (T2DM). METHODS: A retrospective cohort of patients 
      with T2DM who were new users of TZDs or alpha glucosidase inhibitors (AGIs) was 
      assembled. We applied the inverse probability of treatment weighted Cox model to 
      estimate the hazard ratio (HR) of RA incidence associated with the use of TZDs 
      compared with AGIs. RESULTS: The final analysis included 56,796 new users of AGIs 
      and 14,892 new users of TZDs. The incidence of RA was 187.4 and 135.2 per 100,000 
      person-years in AGI users and TZD users, respectively. Compared with use of AGIs, 
      TZD use was associated with a reduction in RA incidence, with an HR of 0.72 (95% 
      confidence interval [95% CI] 0.59-0.89). HRs for cumulative use of TZDs for 0.51 
      to 4.0 years and more than 4 years with incidence of RA were 0.55 (95% CI 
      0.35-0.88) and 0.74 (95% CI 0.57-0.98), respectively. Various subgroup analyses 
      and sensitivity analyses were consistent with the primary analysis. CONCLUSION: 
      Use of TZDs is associated with a decreased risk of incident RA in patients with 
      T2DM.
CI  - (c) 2023 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC 
      on behalf of American College of Rheumatology.
FAU - Zhao, Houyu
AU  - Zhao H
AUID- ORCID: 0000-0002-4546-9342
AD  - Peking University, Beijing, China.
FAU - Chen, Xiaowei
AU  - Chen X
AD  - Peking University, Beijing, China, and Tianjin Medical University, Tianjin, 
      China.
FAU - Sun, Yexiang
AU  - Sun Y
AD  - Yinzhou District Center for Disease Control and Prevention, Ningbo, China.
FAU - Shen, Peng
AU  - Shen P
AD  - Yinzhou District Center for Disease Control and Prevention, Ningbo, China.
FAU - Lin, Hongbo
AU  - Lin H
AD  - Yinzhou District Center for Disease Control and Prevention, Ningbo, China.
FAU - Sun, Feng
AU  - Sun F
AD  - Peking University, Beijing, China.
FAU - Zhan, Siyan
AU  - Zhan S
AUID- ORCID: 0000-0001-7252-5349
AD  - Peking University and Peking University Third Hospital, Beijing, China.
LA  - eng
GR  - 2022M710251/China Postdoctoral Science Foundation/
GR  - 2023T160032/China Postdoctoral Science Foundation/
GR  - 82204157/National Natural Science Foundation of China/
GR  - 72074011/National Natural Science Foundation of China/
GR  - 81973146/National Natural Science Foundation of China/
GR  - 2020YJSZX-2/Special Project for Director, China Center for Evidence Based 
      Traditional Chinese Medicine/
GR  - [2021]37-10/Key Projects of Scientific Act for Drug Regulation of China/
PT  - Journal Article
DEP - 20240201
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
RN  - 0 (Thiazolidinediones)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Humans
MH  - *Thiazolidinediones/adverse effects
MH  - *Diabetes Mellitus, Type 2/diagnosis/drug therapy/epidemiology
MH  - Retrospective Studies
MH  - Hypoglycemic Agents/adverse effects
MH  - Cohort Studies
MH  - Incidence
MH  - *Arthritis, Rheumatoid/diagnosis/drug therapy/epidemiology
MH  - Risk Factors
EDAT- 2023/12/18 06:42
MHDA- 2024/03/26 06:45
CRDT- 2023/12/18 05:13
PHST- 2023/11/21 00:00 [revised]
PHST- 2023/06/12 00:00 [received]
PHST- 2023/12/05 00:00 [accepted]
PHST- 2024/03/26 06:45 [medline]
PHST- 2023/12/18 06:42 [pubmed]
PHST- 2023/12/18 05:13 [entrez]
AID - 10.1002/acr.25277 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2024 Apr;76(4):486-496. doi: 10.1002/acr.25277. 
      Epub 2024 Feb 1.