PMID- 38108579
OWN - NLM
STAT- MEDLINE
DCOM- 20240105
LR  - 20240116
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 12
IP  - 2
DP  - 2024 Jan 3
TI  - Glucose microenvironment sensitive degradation of arginine modified calcium 
      sulfate reinforced poly(lactide-co-glycolide) composite scaffolds.
PG  - 508-524
LID - 10.1039/d3tb01595e [doi]
AB  - Poly(lactide-co-glycolide) (PLGA) and calcium sulfate composites are promising 
      biodegradable biomaterials but are still challenging to use in people with high 
      levels of blood glucose or diabetes. To date, the influence of glucose on their 
      degradation has not yet been elucidated and thus calls for more research 
      attention. Herein, a novel calcium sulfate whisker with L-arginine was used to 
      effectively tune its crystal morphology and was employed as a reinforced phase to 
      construct the PLGA-based composite scaffolds (ArgCSH/PLGA) with a sleeve porous 
      structure. ArgCSH/PLGA showed excellent elastic modulus and strength in the 
      compression and bending models. Moreover, an in vitro immersion test showed that 
      ArgCSH/PLGA possessed degradation and redeposition behaviors sensitive to glucose 
      concentration, and the adsorbed Arg played a crucial role in the degradation 
      process. The subsequent cell functional evaluation showed that ArgCSH could 
      effectively protect cells from damage caused by AGEs and promote osteogenic 
      differentiation. The corresponding degradation products of ArgCSH/PLGA displayed 
      the ability to regulate osteoblast bone differentiation and accelerate matrix 
      mineralization. These findings provide new insights into the interaction between 
      biomaterials and the physiological environment, which may be useful in expanding 
      the targeted choice of efficient bone graft biodegradable materials for diabetic 
      osteoporosis.
FAU - Zhu, Yongzhan
AU  - Zhu Y
AD  - 8th Department of Orthopaedics, Foshan Hospital of Traditional Chinese Medicine, 
      Foshan 528000, P. R. China. Zhuyz@fshtcm.com.cn.
FAU - Li, Yinghao
AU  - Li Y
AUID- ORCID: 0000-0002-7090-6786
AD  - 8th Department of Orthopaedics, Foshan Hospital of Traditional Chinese Medicine, 
      Foshan 528000, P. R. China. Zhuyz@fshtcm.com.cn.
FAU - Zhou, Xiaosong
AU  - Zhou X
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China. 
      guomin@ciac.ac.cn.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, 96 Jinzhai Road, Hefei, Anhui 230026, P. R. China.
FAU - Li, Haoxuan
AU  - Li H
AD  - Department of Spine Surgery, China-Japan Union Hospital of Jilin University, N. 
      126 Xiantai Street, Changchun 130033, Jilin, P. R. China.
FAU - Guo, Min
AU  - Guo M
AUID- ORCID: 0000-0003-4450-4270
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China. 
      guomin@ciac.ac.cn.
FAU - Zhang, Peibiao
AU  - Zhang P
AUID- ORCID: 0000-0003-0073-6467
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China. 
      guomin@ciac.ac.cn.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, 96 Jinzhai Road, Hefei, Anhui 230026, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20240103
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 34346-01-5 (Polyglactin 910)
RN  - WAT0DDB505 (Calcium Sulfate)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 94ZLA3W45F (Arginine)
RN  - 0 (Biocompatible Materials)
SB  - IM
MH  - Humans
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - *Osteogenesis
MH  - *Polyglactin 910/chemistry
MH  - Calcium Sulfate
MH  - Polyglycolic Acid/chemistry
MH  - Lactic Acid/chemistry
MH  - Arginine/pharmacology
MH  - Biocompatible Materials/pharmacology/chemistry
EDAT- 2023/12/18 12:42
MHDA- 2024/01/05 06:42
CRDT- 2023/12/18 09:53
PHST- 2024/01/05 06:42 [medline]
PHST- 2023/12/18 12:42 [pubmed]
PHST- 2023/12/18 09:53 [entrez]
AID - 10.1039/d3tb01595e [doi]
PST - epublish
SO  - J Mater Chem B. 2024 Jan 3;12(2):508-524. doi: 10.1039/d3tb01595e.