PMID- 38108832
OWN - NLM
STAT- MEDLINE
DCOM- 20231219
LR  - 20231225
IS  - 1479-9731 (Electronic)
IS  - 1479-9723 (Print)
IS  - 1479-9723 (Linking)
VI  - 20
DP  - 2023 Jan-Dec
TI  - Physical activity in idiopathic pulmonary fibrosis: Longitudinal change and 
      minimal clinically important difference.
PG  - 14799731231221818
LID - 10.1177/14799731231221818 [doi]
LID - 14799731231221818
AB  - BACKGROUND AND OBJECTIVE: Reference values of physical activity to interpret 
      longitudinal changes are not available in patients with idiopathic pulmonary 
      fibrosis (IPF). This study aimed to define the minimal clinical important 
      difference (MCID) of longitudinal changes in physical activity in patients with 
      IPF. METHODS: Using accelerometry, physical activity (steps per day) was measured 
      and compared at baseline and 6-months follow-up in patients with IPF. We 
      calculated MCID of daily step count using multiple anchor-based and 
      distribution-based methods. Forced vital capacity and 6-minute walk distance were 
      applied as anchors in anchor-based methods. Effect size and standard error of 
      measurement were used to calculate MCID in distribution-based methods. RESULTS: 
      One-hundred and five patients were enrolled in the study (mean age: 68.5 +/- 
      7.5 years). Step count significantly decreased from baseline to 6-months 
      follow-up (-461 +/- 2402, p = .031). MCID calculated by anchor-based and 
      distribution-based methods ranged from 570-1358 steps. CONCLUSION: Daily step 
      count significantly declined over 6-months in patients with IPF. MCID calculated 
      by multiple anchor-based and distribution-based methods was 570 to 1358 
      steps/day. These findings contribute to interpretation of the longitudinal 
      changes of physical activity that will assist its use as a clinical and research 
      outcome in patients with IPF.
FAU - Shingai, Kazuya
AU  - Shingai K
AUID- ORCID: 0000-0001-9036-6636
AD  - Department of Physical Therapy Science, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan. RINGGOLD: 200674
FAU - Matsuda, Toshiaki
AU  - Matsuda T
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, 
      Japan. RINGGOLD: 37091
FAU - Kondoh, Yasuhiro
AU  - Kondoh Y
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, 
      Japan. RINGGOLD: 37091
FAU - Kimura, Tomoki
AU  - Kimura T
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, 
      Japan. RINGGOLD: 37091
FAU - Kataoka, Kensuke
AU  - Kataoka K
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, 
      Japan. RINGGOLD: 37091
FAU - Yokoyama, Toshiki
AU  - Yokoyama T
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, 
      Japan. RINGGOLD: 37091
FAU - Yamano, Yasuhiko
AU  - Yamano Y
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, 
      Japan. RINGGOLD: 37091
FAU - Ogawa, Tomoya
AU  - Ogawa T
AD  - Department of Rehabilitation, Tosei General Hospital, Seto, Japan. RINGGOLD: 
      37091
FAU - Watanabe, Fumiko
AU  - Watanabe F
AD  - Department of Rehabilitation, Tosei General Hospital, Seto, Japan. RINGGOLD: 
      37091
FAU - Hirasawa, Jun
AU  - Hirasawa J
AD  - Department of Rehabilitation, Tosei General Hospital, Seto, Japan. RINGGOLD: 
      37091
FAU - Reid, W Darlene
AU  - Reid WD
AUID- ORCID: 0000-0001-9980-8699
AD  - Department of Physical Therapy, University of Toronto, Toronto, Canada. RINGGOLD: 
      7938
AD  - Interdepartmental Division of Critical Care Medicine, University of Toronto, 
      Toronto, Canada. RINGGOLD: 7938
AD  - KITE, Toronto Rehabilitation Institute, University Health Network, Toronto, 
      Canada.
FAU - Kozu, Ryo
AU  - Kozu R
AUID- ORCID: 0000-0002-9310-185X
AD  - Department of Physical Therapy Science, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan. RINGGOLD: 200674
LA  - eng
PT  - Journal Article
PL  - England
TA  - Chron Respir Dis
JT  - Chronic respiratory disease
JID - 101197408
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Minimal Clinically Important Difference
MH  - Exercise
MH  - *Idiopathic Pulmonary Fibrosis
MH  - Walking
MH  - Accelerometry
PMC - PMC10748643
OTO - NOTNLM
OT  - Accelerometry
OT  - exercise
OT  - exercise test
OT  - idiopathic pulmonary fibrosis
OT  - minimal clinically important difference
OT  - rehabilitation
COIS- Declaration Of Conflicting InterestsThe author(s) declared the following 
      potential conflicts of interest with respect to the research, authorship, and/or 
      publication of this article: Yasuhiro Kondoh reports advisory board fees and 
      personal fees from Asahi Kasei Pharma Corp., Shionogi & Co.Ltd., and Boehringer 
      Ingelheim Co., Ltd., advisory board fees from Janssen Pharmaceutical K.K., 
      Healios K.K., Chugai Pharmaceutical Co., Ltd., and Taiho Pharmaceutical Co., 
      Ltd., and personal fees from AstraZeneca K.K., Eisai inc., KYORIN Pharmaceutical 
      Co., Ltd., Mitsubishi Tanabe Pharma, and Novartis Pharma K.K., outside the 
      presentation work. Kensuke Kataoka and Yasuhiko Yamano received lecture fees from 
      Nippon Boehringer, Ingelheim Co., Ltd., outside the submitted work. All other 
      authors declared no conflict of interest.
EDAT- 2023/12/18 12:41
MHDA- 2023/12/19 06:42
PMCR- 2023/12/18
CRDT- 2023/12/18 11:03
PHST- 2023/12/19 06:42 [medline]
PHST- 2023/12/18 12:41 [pubmed]
PHST- 2023/12/18 11:03 [entrez]
PHST- 2023/12/18 00:00 [pmc-release]
AID - 10.1177_14799731231221818 [pii]
AID - 10.1177/14799731231221818 [doi]
PST - ppublish
SO  - Chron Respir Dis. 2023 Jan-Dec;20:14799731231221818. doi: 
      10.1177/14799731231221818.