PMID- 38109003
OWN - NLM
STAT- Publisher
LR  - 20231218
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
DP  - 2023 Dec 18
TI  - Association Between Combined Polymetallic Exposure and Osteoporosis.
LID - 10.1007/s12011-023-04002-6 [doi]
AB  - Combined polymetallic exposure may be an influential factor in osteoporosis. This 
      study aimed to explore the association between polymetallic combined exposure and 
      osteoporosis. A total of 2115 participants were included. Plasma concentrations 
      of 22 metals were determined by inductively coupled plasma mass spectrometry. 
      Osteoporosis was defined as a T </=  - 2.5. The least absolute shrinkage and 
      selection operator (LASSO) regression, binary logistics regression, and Bayesian 
      kernel machine regression (BKMR) model were used to explore the association 
      between plasma metals and osteoporosis. LASSO regression showed that 10 metals 
      were associated with osteoporosis in the total population (magnesium, calcium, 
      manganese, nickel, cobalt, arsenic, selenium, rubidium, cadmium, aluminum) and 
      women (magnesium, calcium, molybdenum, nickel, cobalt, arsenic, selenium, 
      rubidium, cadmium, aluminum), and four metals associated with men (magnesium, 
      cobalt, aluminum, iron). Logistics regression showed that in total population, 
      magnesium (OR(Q3) = 0.653, 95% CI = 0.446-0.954) was negatively correlated with 
      osteoporosis, while aluminum (OR(Q2) = 1.569, 95% CI = 1.095-2.248, 
      OR(Q4) = 1.616, 95% CI = 1.109-2.354) and cadmium (OR(Q4) = 1.989, 95% 
      CI = 1.379-2.870) were positively correlated; in women, magnesium 
      (OR(Q3) = 0.579, 95% CI = 0.379-0.883) was negatively correlated with 
      osteoporosis, while aluminum (OR(Q2) = 1.563, 95% CI = 1.051-2.326, 
      OR(Q4) = 1.543, 95% CI = 1.024-2.326) and cadmium (OR(Q3) = 1.482, 95% 
      CI = 1.003-2.191, OR(Q4) = 1.740, 95% CI = 1.167-2.596) were positively 
      correlated. BKMR model showed that combined polymetallic exposure had an overall 
      positive effect on osteoporosis, magnesium was negatively associated with 
      osteoporosis, and cadmium, selenium, and aluminum were positively associated with 
      osteoporosis. Metal mixtures in plasma were associated with osteoporosis risk. 
      Magnesium may reduce the risk of osteoporosis, while cadmium, selenium, and 
      aluminum may increase the risk of osteoporosis. Future studies needed to explore 
      correlations and mechanisms.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Qin, Lidong
AU  - Qin L
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Liu, Qiumei
AU  - Liu Q
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Zhang, Tiantian
AU  - Zhang T
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Tang, Xu
AU  - Tang X
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Mo, Xiaoting
AU  - Mo X
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Liang, Yujian
AU  - Liang Y
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Wang, Xuexiu
AU  - Wang X
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Cao, Jiejing
AU  - Cao J
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Huang, Chuwu
AU  - Huang C
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Lu, Yufu
AU  - Lu Y
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
FAU - Zhang, Zhiyong
AU  - Zhang Z
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
AD  - Department of Environmental Health and Occupational Medicine, School of Public 
      Health, Guilin Medical University, Guilin, China.
AD  - Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, 
      Guilin Medical University, Guilin, China.
FAU - Qin, Jian
AU  - Qin J
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China. 
      qinjian@gxmu.edu.cn.
AD  - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of 
      Highly Prevalent Diseases, Guangxi Medical University, Nanning, China. 
      qinjian@gxmu.edu.cn.
AD  - Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical 
      University, Nanning, China. qinjian@gxmu.edu.cn.
AD  - Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of 
      Education, Guangxi Medical University, Nanning, China. qinjian@gxmu.edu.cn.
FAU - Cai, Jiansheng
AU  - Cai J
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China. 
      15007714226@163.com.
AD  - Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin 
      Medical University, Huan Cheng North 2Nd Road 109, Guilin, 541004, Guangxi, 
      China. 15007714226@163.com.
LA  - eng
GR  - 81960583/National Natural Science Foundation of China/
GR  - 81660528/National Natural Science Foundation of China/
GR  - AA22096026/Major Science and Technology Projects in Guangxi/
GR  - AD 17129003/Guangxi Science and Technology Development Project/
GR  - 2019GXNSFGA245002/Guangxi Natural Science Foundation for Innovation Research 
      Team/
GR  - 20220120-2/Innovation Platform and Talent Plan in Guilin/
PT  - Journal Article
DEP - 20231218
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
SB  - IM
OTO - NOTNLM
OT  - Aluminum
OT  - Bayesian kernel machine regression
OT  - Cadmium
OT  - Magnesium
OT  - Osteoporosis
OT  - Plasma metal mixture
EDAT- 2023/12/18 12:41
MHDA- 2023/12/18 12:41
CRDT- 2023/12/18 11:11
PHST- 2023/09/11 00:00 [received]
PHST- 2023/12/05 00:00 [accepted]
PHST- 2023/12/18 12:41 [medline]
PHST- 2023/12/18 12:41 [pubmed]
PHST- 2023/12/18 11:11 [entrez]
AID - 10.1007/s12011-023-04002-6 [pii]
AID - 10.1007/s12011-023-04002-6 [doi]
PST - aheadofprint
SO  - Biol Trace Elem Res. 2023 Dec 18. doi: 10.1007/s12011-023-04002-6.