PMID- 38111098
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240405
IS  - 1738-3536 (Print)
IS  - 2005-6184 (Electronic)
IS  - 1738-3536 (Linking)
VI  - 87
IP  - 2
DP  - 2024 Apr
TI  - Association between Antacid Exposure and Risk of Interstitial Lung Diseases.
PG  - 185-193
LID - 10.4046/trd.2023.0093 [doi]
AB  - BACKGROUND: The mechanisms leading to lung fibrosis are still under 
      investigation. This study aimed to demonstrate whether antacids could prevent the 
      development of interstitial lung disease (ILD). METHODS: This population-based 
      longitudinal cohort study was conducted between January 2006 and December 2010 in 
      South Korea. Eligible subjects were >/=40 years of age, exposed to proton pump 
      inhibitors (PPI)+/-histamine-2 receptor antagonists (H-2 blockers) or H-2 blockers 
      only, and had no history of ILD between 2004 and 2005. Exposure to antacids was 
      defined as the administration of either PPI or H-2 receptor antagonists for 
      >14 days, whereas underexposure was defined as antacid treatment administered 
      for less than 14 days. Newly developed ILDs, including idiopathic pulmonary 
      fibrosis (IPF), were counted during the 5-year observation period. The 
      association between antacid exposure and ILD development was evaluated using 
      adjusted Cox regression models with variables, such as age, sex, smoking history, 
      and comorbidities. RESULTS: The incidence rates of ILD with/without antacid use 
      were 43.2 and 33.8/100,000 person-years, respectively and those of IPF were 14.9 
      and 22.9/100,000 person-years, respectively. In multivariable analysis, exposure 
      to antacid before the diagnosis of ILD was independently associated with a 
      reduced development of ILD (hazard ratio [HR], 0.57; 95% confidence interval 
      [CI], 0.45 to 0.71; p<0.001), while antacid exposure was not associated with 
      development of IPF (HR, 0.88; 95% CI, 0.72 to 1.09; p=0.06). CONCLUSION: Antacid 
      exposure may be independently associated with a decreased risk of ILD 
      development.
FAU - Bae, Soohyun
AU  - Bae S
AD  - Department of Internal Medicine, Myongji Hospital, Hanyang University College of 
      Medicine, Goyang, Republic of Korea.
FAU - Loloci, Gjustina
AU  - Loloci G
AD  - Department of Internal Medicine, Myongji Hospital, Hanyang University College of 
      Medicine, Goyang, Republic of Korea.
AD  - German Hospital of Tirana, Tirana, Albania.
FAU - Lee, Dong Yoon
AU  - Lee DY
AD  - Department of Internal Medicine, Myongji Hospital, Hanyang University College of 
      Medicine, Goyang, Republic of Korea.
FAU - Jang, Hye Jin
AU  - Jang HJ
AD  - Department of Internal Medicine, Myongji Hospital, Hanyang University College of 
      Medicine, Goyang, Republic of Korea.
FAU - Jeong, Jihyeon
AU  - Jeong J
AD  - Department of Statistics, Kyungpook National University, Daegu, Republic of 
      Korea.
FAU - Choi, Won-Il
AU  - Choi WI
AD  - Department of Internal Medicine, Myongji Hospital, Hanyang University College of 
      Medicine, Goyang, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20231219
PL  - Korea (South)
TA  - Tuberc Respir Dis (Seoul)
JT  - Tuberculosis and respiratory diseases
JID - 101479418
PMC - PMC10990614
OTO - NOTNLM
OT  - Antacid Exposure
OT  - Idiopathic Pulmonary Fibrosis
OT  - Incidence
OT  - Interstitial Lung Disease
COIS- Conflicts of Interest Hye Jin Jang is an editorial board member of the journal, 
      but she was not involved in the peer reviewer selection, evaluation, or decision 
      process of this article. No other potential conflicts of interest relevant to 
      this article were reported.
EDAT- 2023/12/19 06:42
MHDA- 2023/12/19 06:43
PMCR- 2024/04/01
CRDT- 2023/12/19 00:43
PHST- 2023/07/11 00:00 [received]
PHST- 2023/12/17 00:00 [accepted]
PHST- 2023/12/19 06:43 [medline]
PHST- 2023/12/19 06:42 [pubmed]
PHST- 2023/12/19 00:43 [entrez]
PHST- 2024/04/01 00:00 [pmc-release]
AID - trd.2023.0093 [pii]
AID - trd-2023-0093 [pii]
AID - 10.4046/trd.2023.0093 [doi]
PST - ppublish
SO  - Tuberc Respir Dis (Seoul). 2024 Apr;87(2):185-193. doi: 10.4046/trd.2023.0093. 
      Epub 2023 Dec 19.