PMID- 38111710
OWN - NLM
STAT- MEDLINE
DCOM- 20231220
LR  - 20240305
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Relationship between advanced lung cancer inflammation index and long-term 
      all-cause, cardiovascular, and cancer mortality among type 2 diabetes mellitus 
      patients: NHANES, 1999-2018.
PG  - 1298345
LID - 10.3389/fendo.2023.1298345 [doi]
LID - 1298345
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) was a major global health threat. As 
      a chronic low-grade inflammatory disease, the prognosis of diabetes was 
      associated with inflammation. The advanced lung cancer inflammation index (ALI) 
      served as a comprehensive index to assess inflammation. This study aimed to 
      estimate the association between ALI and all-cause, cardiovascular disease (CVD), 
      and cancer mortality in T2DM patients. METHODS: We extracted cohort data from the 
      National Health and Nutrition Examination Survey (NHANES) spanning 1999-2018 for 
      analysis. The weighted Kaplan-Meier analysis and multivariate-adjusted Cox 
      analysis were utilized to evaluate the relationship between ALI and all-cause, 
      CVD, and cancer mortality in T2DM patients. Restricted cubic spline (RCS) 
      analysis was employed to assess their non-linear relationship. Stratified 
      analysis and interaction analysis were conducted to enhance the robustness of the 
      results. RESULTS: The study incorporated a total of 3,888 patients. An increase 
      in ALI was associated with a reduced risk of all-cause and CVD mortality in T2DM 
      patients, but not related to cancer mortality. There were J-shaped and L-shaped 
      non-linear relationships between ALI and all-cause, CVD mortality in T2DM 
      patients, respectively. The inflection points were 90.20 and 93.06, respectively. 
      For values below the inflection point, every 10U increase in ALI, both all-cause 
      and CVD mortality risk decreased by 9%. Beyond the inflection point, all-cause 
      mortality rose by 3%, while CVD mortality remained unaffected. Gender-stratified 
      RCS analysis indicated a linear negative relationship between CVD mortality and 
      ALI in female T2DM patients, whereas the trend in males aligned with the overall 
      population. CONCLUSION: Our research initially identified a significant 
      correlation between increased ALI levels with decreased all-cause and CVD 
      mortality in T2DM patients. There were J-shaped and L-shaped non-linear 
      relationships between ALI and all-cause, CVD mortality in T2DM patients, 
      respectively. For female patients, there was a linear negative relation between 
      CVD mortality and ALI, whereas the trend in males aligned with the overall 
      population. These findings suggested that maintaining ALI (for example, control 
      body weight and keep albumin in the normal range) within a certain range in the 
      clinical settings was crucial for improving all-cause and CVD mortality in T2DM 
      patients.
CI  - Copyright (c) 2023 Chen, Guan, Wang and Wang.
FAU - Chen, Yaying
AU  - Chen Y
AD  - Department of Physical Examination Center, Xiamen Humanity Hospital of Fujian 
      Medical University, Xiamen, Fujian, China.
FAU - Guan, Mengqian
AU  - Guan M
AD  - Fuzhou International Travel Health Care Center, Fuzhou, China.
FAU - Wang, Ruiqi
AU  - Wang R
AD  - Department of Gastroenterology, Xiamen Humanity Hospital of Fujian Medical 
      University, Xiamen, Fujian, China.
FAU - Wang, Xuewen
AU  - Wang X
AD  - Department of Histology and Embryology, School of Basic Medical Sciences, Fujian 
      Medical University, Fuzhou, Fujian, China.
LA  - eng
PT  - Journal Article
DEP - 20231128
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Nutrition Surveys
MH  - *Lung Neoplasms/complications
MH  - *Cardiovascular Diseases/epidemiology
MH  - Inflammation/complications
PMC - PMC10726345
OTO - NOTNLM
OT  - CVD mortality
OT  - National Health and Nutrition Examination Survey
OT  - advanced lung cancer inflammation index
OT  - all-cause mortality
OT  - cancer mortality
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/12/19 06:41
MHDA- 2023/12/20 06:42
PMCR- 2023/01/01
CRDT- 2023/12/19 03:56
PHST- 2023/09/21 00:00 [received]
PHST- 2023/11/07 00:00 [accepted]
PHST- 2023/12/20 06:42 [medline]
PHST- 2023/12/19 06:41 [pubmed]
PHST- 2023/12/19 03:56 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1298345 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Nov 28;14:1298345. doi: 
      10.3389/fendo.2023.1298345. eCollection 2023.