PMID- 38111999
OWN - NLM
STAT- MEDLINE
DCOM- 20231221
LR  - 20231221
IS  - 1746-076X (Electronic)
IS  - 1746-0751 (Linking)
VI  - 18
IP  - 12
DP  - 2023 Dec
TI  - A 'one stone, two birds' approach with mesenchymal stem cells for acute 
      respiratory distress syndrome and Type II diabetes mellitus.
PG  - 913-934
LID - 10.2217/rme-2023-0193 [doi]
AB  - This review explores the intricate relationship between acute respiratory 
      distress syndrome (ARDS) and Type II diabetes mellitus (T2DM). It covers ARDS 
      epidemiology, etiology and pathophysiology, along with current treatment trends 
      and challenges. The lipopolysaccharides (LPS) role in ARDS and its association 
      between non-communicable diseases and COVID-19 are discussed. The review 
      highlights the therapeutic potential of human umbilical cord-derived mesenchymal 
      stem cells (hUC-MSCs) for ARDS and T2DM, emphasizing their immunomodulatory 
      effects. This review also underlines how T2DM exacerbates ARDS pathophysiology 
      and discusses the potential of hUC-MSCs in modulating immune responses. In 
      conclusion, the review highlights the multidisciplinary approach to managing ARDS 
      and T2DM, focusing on inflammation, oxidative stress and potential therapy of 
      hUC-MSCs in the future.
FAU - Sababathy, Mogesh
AU  - Sababathy M
AUID- ORCID: 0000-0002-9635-3278
AD  - Department of Veterinary Pathology & Microbiology, Faculty of Veterinary 
      Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
FAU - Ramanathan, Ghayathri
AU  - Ramanathan G
AUID- ORCID: 0000-0001-7754-4522
AD  - Faculty of Computer Science & Information Technology, Universiti Malaya, 50603, 
      Kuala Lumpur, Malaysia.
FAU - Abd Rahaman, Nor Yasmin
AU  - Abd Rahaman NY
AUID- ORCID: 0000-0002-5217-565X
AD  - Department of Veterinary Laboratory Diagnostics, Faculty of Veterinary Medicine, 
      Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
AD  - Laboratory of Vaccines & Biomolecules, Institute of Bioscience, Universiti Putra 
      Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
FAU - Ramasamy, Rajesh
AU  - Ramasamy R
AUID- ORCID: 0000-0003-4227-0458
AD  - Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra 
      Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
FAU - Biau, Foo Jhi
AU  - Biau FJ
AUID- ORCID: 0000-0002-5880-2220
AD  - Centre for Drug Discovery & Molecular Pharmacology (CDDMP), Faculty of Health & 
      Medical Sciences, Taylor's University, Selangor, Subang Jaya, 47500, Malaysia.
AD  - School of Pharmacy, Faculty of Health & Medical Sciences, Taylor's University, 
      Selangor, Subang Jaya, 47500, Malaysia.
FAU - Qi Hao, Daniel Looi
AU  - Qi Hao DL
AD  - My Cytohealth Sdn. Bhd., 18-2, Jalan Radin Bagus 1, Bandar Seri Petaling, Kuala 
      Lumpur, 57000, Malaysia.
FAU - Hamid, Nur-Fazila Saulol
AU  - Hamid NS
AUID- ORCID: 0000-0002-9324-2417
AD  - Department of Veterinary Pathology & Microbiology, Faculty of Veterinary 
      Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
AD  - Laboratory of Vaccines & Biomolecules, Institute of Bioscience, Universiti Putra 
      Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
LA  - eng
GR  - FRGS/1/2020/SKK06/UPM/02/16/Ministry of Higher Education of Malaysia/
PT  - Journal Article
PT  - Review
DEP - 20231219
PL  - England
TA  - Regen Med
JT  - Regenerative medicine
JID - 101278116
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/therapy
MH  - *Respiratory Distress Syndrome/therapy
MH  - Inflammation
MH  - *COVID-19/therapy
MH  - *Mesenchymal Stem Cells
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Umbilical Cord
OTO - NOTNLM
OT  - Type II diabetes mellitus
OT  - acute respiratory distress syndrome
OT  - human umbilical cord-derived mesenchymal stem cells
OT  - lipopolysaccharide
OT  - non-communicable disease
EDAT- 2023/12/19 06:41
MHDA- 2023/12/21 06:42
CRDT- 2023/12/19 04:13
PHST- 2023/12/21 06:42 [medline]
PHST- 2023/12/19 06:41 [pubmed]
PHST- 2023/12/19 04:13 [entrez]
AID - 10.2217/rme-2023-0193 [doi]
PST - ppublish
SO  - Regen Med. 2023 Dec;18(12):913-934. doi: 10.2217/rme-2023-0193. Epub 2023 Dec 19.