PMID- 38113025
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240116
IS  - 2193-8245 (Print)
IS  - 2193-6528 (Electronic)
VI  - 13
IP  - 2
DP  - 2024 Feb
TI  - Subfoveal and Parafoveal Choroidal Thickening in Patients with Keratoconus Using 
      the ETDRS Grid on Swept-Source OCT.
PG  - 509-527
LID - 10.1007/s40123-023-00858-y [doi]
AB  - INTRODUCTION: There is growing evidence that confirms morphological changes in 
      the posterior structures in patients with keratoconus (KC); however, isolated 
      alterations could have been missed. This study assesses choroidal thickness (CT) 
      in the fovea and beyond in KC eyes. METHODS: This prospective case-control and 
      non-randomized study enrolled 107 eyes, 62 eyes of 62 patients with KC, and 45 
      age-matched eyes of 45 control subjects with axial length in the range of 
      22-26 mm. Swept-source optical coherence tomography (SS-OCT) was performed to 
      manually measure the subfoveal choroidal thickness (SCT) using a single-line 
      scan. CT was obtained automatically from the Early Treatment Diabetic Retinopathy 
      Study (ETDRS) grid using the 12-lines radial scan pattern. A two-way 
      repeated-measures analysis of variance (ANOVA) was conducted to evaluate CT 
      variations among macular eccentricity, parafoveal area, and the interaction 
      between both factors. CT was compared in all parafoveal areas between groups and 
      subgroups of KC. RESULTS: SCT was significantly thicker in KC eyes (357 +/- 57 microm) 
      than in healthy eyes (325 +/- 63 microm) (p < 0.001). Significant choroidal thickening 
      was observed in the central ring and outer and inner rings of the temporal, 
      superior, and inferior parafoveal macular areas (p < 0.001), except in the outer 
      ring of the nasal macular zone (p > 0.05) of KC compared to healthy eyes. The CT 
      significantly decreased from the center to the outer ring regardless of the 
      presence of KC (p < 0.001). The choroid in the nasal macular zone was 
      significantly thinner than that in the temporal, superior, and inferior 
      parafoveal areas (p < 0.001). CONCLUSIONS: The choroidal structure increased its 
      thickness not only in the subfoveal area, but also in eight parafoveal areas of 
      the ETDRS grid encompassing a wider area of macular examination. These findings 
      demonstrate and corroborate that keratoconus is not a purely corneal disease. 
      Furthermore, it confirms the role that the choroidal structure has in the 
      pathophysiology of keratoconus.
CI  - (c) 2023. The Author(s).
FAU - Burguera-Gimenez, Neus
AU  - Burguera-Gimenez N
AUID- ORCID: 0000-0002-0508-1431
AD  - Anterior Segment and Cornea and External Eye Diseases Unit, Fundacion de 
      Oftalmologia Medica (FOM), Avda. Pio Baroja, 12, 46015, Valencia, Spain. 
      neus.burguera@uv.es.
AD  - Department of Optics and Optometry and Vision Sciences, Physics School, 
      University of Valencia, Dr. Moliner, 50, 46100, Valencia, Spain. 
      neus.burguera@uv.es.
FAU - Diez-Ajenjo, M feminine Amparo
AU  - Diez-Ajenjo MA
AUID- ORCID: 0000-0002-8146-4039
AD  - Anterior Segment and Cornea and External Eye Diseases Unit, Fundacion de 
      Oftalmologia Medica (FOM), Avda. Pio Baroja, 12, 46015, Valencia, Spain.
AD  - Department of Optics and Optometry and Vision Sciences, Physics School, 
      University of Valencia, Dr. Moliner, 50, 46100, Valencia, Spain.
FAU - Burguera, Noemi
AU  - Burguera N
AUID- ORCID: 0000-0002-3735-6452
AD  - Ophthalmology Department, Q Vision, Vithas Virgen del Mar Hospital, Ctra. el Mami 
      a Viator, Km.1, 04120, Almeria, Spain.
FAU - Briceno-Lopez, Celeste
AU  - Briceno-Lopez C
AUID- ORCID: 0009-0004-9363-5482
AD  - Anterior Segment and Cornea and External Eye Diseases Unit, Fundacion de 
      Oftalmologia Medica (FOM), Avda. Pio Baroja, 12, 46015, Valencia, Spain.
AD  - Department of Optics and Optometry and Vision Sciences, Physics School, 
      University of Valencia, Dr. Moliner, 50, 46100, Valencia, Spain.
FAU - Peris-Martinez, Cristina
AU  - Peris-Martinez C
AUID- ORCID: 0000-0001-5992-5006
AD  - Anterior Segment and Cornea and External Eye Diseases Unit, Fundacion de 
      Oftalmologia Medica (FOM), Avda. Pio Baroja, 12, 46015, Valencia, Spain.
AD  - Surgery Department, Ophthalmology, School of Medicine, University of Valencia, 
      Av. Blasco Ibanez, 15, 46010, Valencia, Spain.
LA  - eng
PT  - Journal Article
DEP - 20231219
PL  - England
TA  - Ophthalmol Ther
JT  - Ophthalmology and therapy
JID - 101634502
PMC - PMC10787729
OTO - NOTNLM
OT  - Choroidal thickening
OT  - ETDRS
OT  - Keratoconus
OT  - Swept-source optical coherence tomography
COIS- The authors Neus Burguera-Gimenez, M feminine. Amparo Diez-Ajenjo, Noemi Burguera, 
      Celeste Briceno-Lopez, and Cristina Peris-Martinez do not have any conflicts of 
      interest to disclose.
EDAT- 2023/12/19 19:53
MHDA- 2023/12/19 19:54
PMCR- 2023/12/19
CRDT- 2023/12/19 11:26
PHST- 2023/09/25 00:00 [received]
PHST- 2023/11/20 00:00 [accepted]
PHST- 2023/12/19 19:54 [medline]
PHST- 2023/12/19 19:53 [pubmed]
PHST- 2023/12/19 11:26 [entrez]
PHST- 2023/12/19 00:00 [pmc-release]
AID - 10.1007/s40123-023-00858-y [pii]
AID - 858 [pii]
AID - 10.1007/s40123-023-00858-y [doi]
PST - ppublish
SO  - Ophthalmol Ther. 2024 Feb;13(2):509-527. doi: 10.1007/s40123-023-00858-y. Epub 
      2023 Dec 19.