PMID- 38113360
OWN - NLM
STAT- MEDLINE
DCOM- 20231221
LR  - 20231221
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 54
IP  - 12
DP  - 2023 Dec
TI  - Clinical Utility of Spectral-Domain Optical Coherence Tomography Marker 
      Disorganization of Retinal Inner Layers in Diabetic Retinopathy.
PG  - 692-700
LID - 10.3928/23258160-20231031-02 [doi]
AB  - BACKGROUND AND OBJECTIVE: Disorganization of retinal inner layers (DRIL) is a 
      potential spectral-domain optical coherence tomography (SD-OCT) imaging biomarker 
      with clinical utility in diabetic retinopathy (DR). PATIENTS AND METHODS: A 
      cross-sectional study was conducted at a large academic center. The cohort was 
      composed of 1,175 patients with type 2 diabetes with and without retinopathy on 
      initial examination between September 2009 and January 2019 (n = 2,083 eyes). DR 
      risk and progression factors were obtained from the medical record. Trained 
      graders masked to patients' clinical histories evaluated SD-OCT scans for DRIL. 
      RESULTS: Of 2,083 eyes, 28.1% (n = 585) demonstrated presence of DRIL with high 
      interrater reliability (K = 0.88, 95% CI 0.86-0.90). DRIL was associated with 
      worse visual acuity (VA) (P < 0.001) and DR severity (P < 0.0001). Insulin users 
      had more severe DR (P < 0.0001). DR-related factors, race (Black, White) and sex 
      (male) were significantly associated with DRIL (P < 0.05). CONCLUSIONS: DRIL was 
      strongly associated with DR severity and worse VA, supporting its utility as an 
      unfavorable prognostic indicator. [Ophthalmic Surg Lasers Imaging Retina 
      2023;54:692-700.].
FAU - Singuri, Srinidhi
AU  - Singuri S
FAU - Luo, Shiming
AU  - Luo S
FAU - Hatipoglu, Dilara
AU  - Hatipoglu D
FAU - Nowacki, Amy S
AU  - Nowacki AS
FAU - Patel, Riya
AU  - Patel R
FAU - Schachat, Andrew P
AU  - Schachat AP
FAU - Ehlers, Justis P
AU  - Ehlers JP
FAU - Singh, Rishi P
AU  - Singh RP
FAU - Anand-Apte, Bela
AU  - Anand-Apte B
FAU - Yuan, Alex
AU  - Yuan A
LA  - eng
PT  - Journal Article
DEP - 20231201
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
MH  - Humans
MH  - Male
MH  - *Diabetic Retinopathy/complications
MH  - Tomography, Optical Coherence/methods
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cross-Sectional Studies
MH  - Reproducibility of Results
MH  - *Macular Edema/diagnosis
MH  - Retrospective Studies
MH  - Fluorescein Angiography/methods
MH  - Retina
EDAT- 2023/12/19 19:53
MHDA- 2023/12/21 06:43
CRDT- 2023/12/19 14:33
PHST- 2023/12/21 06:43 [medline]
PHST- 2023/12/19 19:53 [pubmed]
PHST- 2023/12/19 14:33 [entrez]
AID - 10.3928/23258160-20231031-02 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2023 Dec;54(12):692-700. doi: 
      10.3928/23258160-20231031-02. Epub 2023 Dec 1.