PMID- 38113872
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1423-0194 (Electronic)
IS  - 0028-3835 (Linking)
VI  - 114
IP  - 4
DP  - 2024
TI  - The Reduced Gray Matter Volume and Functional Connectivity of the Cerebellum in 
      Type 2 Diabetes Mellitus with High Insulin Resistance.
PG  - 386-399
LID - 10.1159/000535860 [doi]
AB  - INTRODUCTION: Insulin resistance is widely thought to be a critical feature in 
      type 2 diabetes mellitus (T2DM), and there is significant evidence indicating a 
      higher abundance of insulin receptors in the human cerebellum than cerebrum. 
      However, the specific structural or functional changes in the cerebellum related 
      to T2DM remain unclear, and the association between cerebellar alterations, 
      insulin resistance, cognition, and emotion is yet to be determined. METHODS: We 
      investigated neuropsychological performance, and structural and functional 
      changes in specific cerebellar subregions in 43 T2DM patients with high insulin 
      resistance (T2DM-highIR), 72 T2DM patients with low insulin resistance 
      (T2DM-lowIR), and 50 controls. Furthermore, the correlation and stepwise multiple 
      linear regression analysis were performed. RESULTS: Compared to the controls, 
      T2DM exhibited lower cognitive scores and higher depressive/anxious scores. 
      Furthermore, T2DM-highIR patients showed reduced gray matter volume (GMV) in the 
      right cerebellar lobules VIIb, Crus I/II, and T2DM showed reduced GMV in left 
      lobules I-IV compared to controls. Additionally, functional connectivity decrease 
      was observed between the right lobules I-V and orbital part of the superior 
      frontal gyrus in T2DM-highIR compared to both T2DM-lowIR and controls. Notably, 
      there were negative correlations between the GMV of the lobules VIIb, Crus I/II, 
      and updated homeostatic model assessment of insulin resistance, and positive 
      correlation with executive/visuospatial performance in T2DM patients. 
      CONCLUSIONS: These results suggest that the cerebellar lobules VIIb, Crus I/II, 
      represent vulnerable brain regions in the context of insulin resistance. Overall, 
      this study offers new insights into the neuropathophysiological mechanisms of 
      brain impairment in patients with T2DM.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Zhang, Hui-Yan
AU  - Zhang HY
AD  - School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
AD  - Department of Radiology, Gansu Provincial Hospital, Lanzhou, China.
FAU - Shen, Guo
AU  - Shen G
AD  - School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
AD  - Department of Radiology, Gansu Provincial Hospital, Lanzhou, China.
FAU - Yang, Chen
AU  - Yang C
AD  - Department of Radiology, Gansu Provincial Hospital, Lanzhou, China.
AD  - The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu 
      Provincial Hospital), Lanzhou, China.
FAU - Tan, Jian
AU  - Tan J
AD  - Department of Radiology, Gansu Provincial Hospital, Lanzhou, China.
AD  - The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu 
      Provincial Hospital), Lanzhou, China.
FAU - Cao, Jian-Cang
AU  - Cao JC
AD  - Department of Radiology, Gansu Provincial Hospital, Lanzhou, China.
FAU - Tian, Jing
AU  - Tian J
AD  - Department of Radiology, Gansu Provincial Hospital, Lanzhou, China.
FAU - Li, Zhou-Le
AU  - Li ZL
AD  - The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu 
      Provincial Hospital), Lanzhou, China.
FAU - Huang, Gang
AU  - Huang G
AD  - Department of Radiology, Gansu Provincial Hospital, Lanzhou, China.
FAU - Zhao, Lian-Ping
AU  - Zhao LP
AD  - Department of Radiology, Gansu Provincial Hospital, Lanzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20231219
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
SB  - IM
MH  - Humans
MH  - Gray Matter/diagnostic imaging
MH  - *Insulin Resistance
MH  - *Diabetes Mellitus, Type 2
MH  - Magnetic Resonance Imaging/methods
MH  - Cerebellum/diagnostic imaging
MH  - *Hyperinsulinism
OTO - NOTNLM
OT  - Cerebellum
OT  - Diabetes mellitus
OT  - Insulin resistance
OT  - Magnetic resonance imaging
OT  - Structure and function
OT  - Type 2
EDAT- 2023/12/19 19:55
MHDA- 2024/04/08 06:42
CRDT- 2023/12/19 18:26
PHST- 2023/09/15 00:00 [received]
PHST- 2023/12/14 00:00 [accepted]
PHST- 2024/04/08 06:42 [medline]
PHST- 2023/12/19 19:55 [pubmed]
PHST- 2023/12/19 18:26 [entrez]
AID - 000535860 [pii]
AID - 10.1159/000535860 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2024;114(4):386-399. doi: 10.1159/000535860. Epub 2023 Dec 
      19.