PMID- 38114385
OWN - NLM
STAT- MEDLINE
DCOM- 20240322
LR  - 20240322
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 20
IP  - 4
DP  - 2024 Apr
TI  - Side-to-side magnetic duodeno-ileostomy in adults with severe obesity with or 
      without type 2 diabetes: early outcomes with prior or concurrent sleeve 
      gastrectomy.
PG  - 341-352
LID - S1550-7289(23)00762-1 [pii]
LID - 10.1016/j.soard.2023.10.018 [doi]
AB  - BACKGROUND: Conventional metabolic/bariatric surgical anastomoses with 
      sutures/staples may cause severe adverse events (AEs). OBJECTIVES: The study aim 
      was to evaluate the feasibility, safety, and effectiveness of primary and 
      revisional side-to-side duodeno-ileostomy (DI) bipartition using a novel magnetic 
      compression anastomosis device (Magnet Anastomosis System [MS]). SETTING: 
      Multicenter: private practices and university hospitals. METHODS: In patients 
      with body mass index ([BMI, kg/m(2)] >/=35.0 to </=50.0 with/without type 2 diabetes 
      [T2D] glycosylated hemoglobin [HbA1C > 6.5 %]), two linear MS magnets were 
      delivered endoscopically to the duodenum and ileum with laparoscopic assistance 
      and aligned, initiating magnet fusion and gradual DI (MagDI). The MagDI-after-SG 
      group had undergone prior sleeve gastrectomy (SG); the MagDI + SG group underwent 
      concurrent SG. AEs were graded by Clavien-Dindo Classification (CDC). RESULTS: 
      Between November 22, 2021 and May 30, 2023, 43 patients (88.0% female, mean age 
      43.7 +/- 1.3 years) underwent the study procedures. The MS met feasibility criteria 
      of magnet device placement, creation of patent anastomoses confirmed 
      radiologically, and magnet passage in 100.0% of patients. There were 64 AEs, most 
      were CDC grade I and II, significantly fewer in the MagDI-after-SG group (P < 
      .001). No device-related AEs including anastomotic leakage, bleeding, 
      obstruction, infection, or death. The MagDI-after-SG group experienced 6-month 
      mean weight loss of 8.0 +/- 2.5 kg (P < .01), 17.4 +/- 5.0% excess weight loss (EWL). 
      The MagDI + SG group had significantly greater weight loss (34.2 +/- 1.6 kg, P < 
      .001), 66.2 +/- 3.4% EWL. All patients with T2D improved. CONCLUSIONS: In early 
      results of a multicenter study, the incisionless, sutureless Magnet System formed 
      patent, complication-free anastomoses in side-to-side DI with prior or concurrent 
      SG.
CI  - Copyright (c) 2024 American Society for Metabolic and Bariatric Surgery. Published 
      by Elsevier Inc. All rights reserved.
FAU - Gagner, Michel
AU  - Gagner M
AD  - Department of Surgery, Westmount Square Surgical Center, Westmount, Quebec, 
      Canada. Electronic address: gagner.michel@cliniquemichelgagner.com.
FAU - Almutlaq, Lamees
AU  - Almutlaq L
AD  - Department of Surgery, Westmount Square Surgical Center, Westmount, Quebec, 
      Canada.
FAU - Cadiere, Guy-Bernard
AU  - Cadiere GB
AD  - Department of Surgery, CHU St-Pierre, Brussels, Belgium.
FAU - Torres, Antonio J
AU  - Torres AJ
AD  - Department of Surgery, Hospital Clinico San Carlos, Madrid, Spain.
FAU - Sanchez-Pernaute, Andres
AU  - Sanchez-Pernaute A
AD  - Department of Surgery, Hospital Clinico San Carlos, Madrid, Spain.
FAU - Buchwald, Jane N
AU  - Buchwald JN
AD  - Medwrite Medical Communications, Maiden Rock, Wisconsin, USA.
FAU - Abuladze, David
AU  - Abuladze D
AD  - Department of Surgery, Innova Medical Center, Tbilisi, Republic of Georgia.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20231110
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
SB  - IM
MH  - Adult
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Male
MH  - *Obesity, Morbid/surgery/etiology
MH  - *Diabetes Mellitus, Type 2/complications/surgery
MH  - Treatment Outcome
MH  - Obesity/surgery
MH  - Duodenum/surgery
MH  - Gastrectomy/methods
MH  - Weight Loss
MH  - Retrospective Studies
MH  - Magnetic Phenomena
MH  - *Gastric Bypass/adverse effects
OTO - NOTNLM
OT  - Duodeno-ileostomy
OT  - Magnet anastomosis system
OT  - Magnetic compression anastomosis
OT  - Metabolic/bariatric surgery
OT  - Obesity
OT  - Sleeve gastrectomy
OT  - Type 2 diabetes
EDAT- 2023/12/20 06:42
MHDA- 2024/03/22 06:44
CRDT- 2023/12/19 22:00
PHST- 2023/06/28 00:00 [received]
PHST- 2023/10/19 00:00 [revised]
PHST- 2023/10/29 00:00 [accepted]
PHST- 2024/03/22 06:44 [medline]
PHST- 2023/12/20 06:42 [pubmed]
PHST- 2023/12/19 22:00 [entrez]
AID - S1550-7289(23)00762-1 [pii]
AID - 10.1016/j.soard.2023.10.018 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2024 Apr;20(4):341-352. doi: 10.1016/j.soard.2023.10.018. 
      Epub 2023 Nov 10.