PMID- 38115289
OWN - NLM
STAT- MEDLINE
DCOM- 20231229
LR  - 20231229
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 102
IP  - 50
DP  - 2023 Dec 15
TI  - MMP-3 gene regulates the carcinogenesis and metabolic process of ovarian cancer, 
      evidence from a Chinese population: Observational study and meta-analysis.
PG  - e36471
LID - 10.1097/MD.0000000000036471 [doi]
LID - e36471
AB  - The current investigation aims to explore the relationship between matrix 
      metalloproteinase-3 (MMP-3) gene polymorphism and ovarian cancer (OC) risk. Two 
      hundred forty pathologically confirmed OC patients and 390 healthy controls 
      participated in the present investigation. Polymerase chain reaction-restriction 
      fragment length polymorphism was applied to investigate the present polymorphism. 
      At the same time, the meta-analysis was also performed to comprehensively explore 
      the relationship. Three genotypes (5A/5A, 5A/6A, and 6A/6A) were observed for 
      MMP-3 gene polymorphism. 6A/6A genotype and 6A allele displayed significant 
      increase in OC patients (all P < .05). Meta-analysis found that no significant 
      results (all P > .05). In conclusion, our results indicate that MMP-3 gene 
      polymorphism contributes increased risk to OC for southern Chinese population. 
      And meta-analysis indicates that MMP-3 gene polymorphism contributes no risk to 
      OC in other populations.
CI  - Copyright (c) 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Pathology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, 
      Suzhou, China.
FAU - Yao, Yanping
AU  - Yao Y
AD  - Department of Pharmacy, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu, 
      People's Republic of China.
FAU - Si, Dan
AU  - Si D
AUID- ORCID: 0009-0007-1551-2729
AD  - Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing 
      Medical University, Suzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.24 (MMP2 protein, human)
SB  - IM
MH  - Female
MH  - Humans
MH  - Carcinogenesis
MH  - Case-Control Studies
MH  - China
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Matrix Metalloproteinase 3/genetics
MH  - Observational Studies as Topic
MH  - *Ovarian Neoplasms/genetics
MH  - Polymorphism, Single Nucleotide
PMC - PMC10727570
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2023/12/20 06:42
MHDA- 2023/12/21 06:42
PMCR- 2023/12/15
CRDT- 2023/12/20 01:01
PHST- 2023/12/21 06:42 [medline]
PHST- 2023/12/20 06:42 [pubmed]
PHST- 2023/12/20 01:01 [entrez]
PHST- 2023/12/15 00:00 [pmc-release]
AID - 00005792-202312150-00050 [pii]
AID - 10.1097/MD.0000000000036471 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2023 Dec 15;102(50):e36471. doi: 
      10.1097/MD.0000000000036471.