PMID- 38115807
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240104
IS  - 1759-9679 (Electronic)
IS  - 1759-9660 (Linking)
VI  - 16
IP  - 2
DP  - 2024 Jan 4
TI  - Magnetic mesoporous Fe(3)O(4)@nSiO(2)@mSiO(2) nanoparticles for high-throughput 
      mass spectrometry detection of hydrolyzed products of organophosphorus nerve 
      agents.
PG  - 301-313
LID - 10.1039/d3ay01785k [doi]
AB  - Rapid and accurate detection of hydrolyzed products of organophosphorus nerve 
      agents (OPNAs) is an important method to effectively confirm the use of these 
      agents. OPNAs are rapidly hydrolyzed to the methyl phosphonates (MPs) in the 
      environment, which can be used as environmental traceability marker for OPNAs. 
      Herein, magnetic mesoporous materials combined with real-time in situ mass 
      spectrometry (MS) were used to achieve high-throughput detection of MPs. Novel 
      magnetic mesoporous nanoparticles Fe(3)O(4)@nSiO(2)@mSiO(2) were synthesized via 
      co-condensation of tetraethyl orthosilicate and cetyltrimethylammonium bromide 
      (CTAB) on the surface of nonporous silica-coated Fe(3)O(4) under alkaline 
      conditions. CTAB templates were removed by the reflux of ethanol (0.0375 mM 
      ammonium nitrate) to form mesoporous SiO(2), which has a large specific surface 
      area of 549 m(2) g(-1) and an excellent magnetization strength of 59.6 emu g(-1). 
      A quick, cost-effective, rugged, and safe magnetic preparation method, magnetic 
      QuEChERS, was established with magnetic mesoporous nanoparticles 
      (Fe(3)O(4)@nSiO(2)@mSiO(2)) as adsorption materials for direct analysis in 
      real-time and tandem MS (DART-MS/MS) of MPs in environmental samples. The method 
      exhibits good linearity (R(2) > 0.992) in the range of 20.0-4.00 mug mL(-1), the 
      limits of detection were <5.00 ng mL(-1), the limits of quantification were <20.0 
      ng mL(-1), and the extraction recoveries were 70.2-98.1%, with relative standard 
      deviations (RSDs) in the range of 1.97-10.6%. Additionally, using this method, 
      analysis of 70 environmental samples could be completed within 20 min. Then, the 
      M-QuEChERS-DART-MS/MS method was applied to the 52nd Organisation for the 
      Prohibition of Chemical Weapons (OPCW) environmental spiked samples analysis, 
      where the accuracy was 95.2-116%, and the RSD was 1.16-7.83%. The results 
      demonstrated that Fe(3)O(4)@nSiO(2)@mSiO(2) based on the QuEChERS method can 
      quickly and efficiently remove the matrix of environmental samples and when 
      coupled with the DART-MS/MS can achieve high-throughput determination of MPs in 
      environmental samples.
FAU - Qu, Gang
AU  - Qu G
AUID- ORCID: 0000-0002-5883-1144
AD  - State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China. 
      ricdyihui@163.com.
FAU - Zhao, Yuxin
AU  - Zhao Y
AD  - State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China. 
      ricdyihui@163.com.
FAU - Zhang, Qiaoli
AU  - Zhang Q
AD  - State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China. 
      ricdyihui@163.com.
FAU - Wu, Jina
AU  - Wu J
AD  - State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China. 
      ricdyihui@163.com.
FAU - Li, Xiaosen
AU  - Li X
AUID- ORCID: 0009-0004-7912-1266
AD  - State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China. 
      ricdyihui@163.com.
FAU - Yang, Yang
AU  - Yang Y
AD  - State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China. 
      ricdyihui@163.com.
FAU - Liu, Shilei
AU  - Liu S
AUID- ORCID: 0000-0001-6154-2661
AD  - State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China. 
      ricdyihui@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240104
PL  - England
TA  - Anal Methods
JT  - Analytical methods : advancing methods and applications
JID - 101519733
SB  - IM
EDAT- 2023/12/20 06:42
MHDA- 2023/12/20 06:43
CRDT- 2023/12/20 03:43
PHST- 2023/12/20 06:43 [medline]
PHST- 2023/12/20 06:42 [pubmed]
PHST- 2023/12/20 03:43 [entrez]
AID - 10.1039/d3ay01785k [doi]
PST - epublish
SO  - Anal Methods. 2024 Jan 4;16(2):301-313. doi: 10.1039/d3ay01785k.