PMID- 38116778
OWN - NLM
STAT- MEDLINE
DCOM- 20231221
LR  - 20240202
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Print)
IS  - 0862-8408 (Linking)
VI  - 72
IP  - S4
DP  - 2023 Dec 17
TI  - Recurrent Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 1 
      Syndrome.
PG  - S423-S427
AB  - Primary hyperparathyroidism is a common endocrinopathy. Multiple Endocrine 
      Neoplasia Type 1 (MEN1) is a rare autosomal dominantly inherited endocrine tumor 
      predisposition syndrome, with one of main manifestations being primary 
      hyperparathyroidism. We retrospectively evaluated a set of 1011 patients who 
      underwent surgery for primary hyperparathyroidism between the years 2018-2022, 
      and found 78 (8 %) patients who underwent reoperations and 27 patients with MEN1 
      syndrome. In the group of patients with MEN1 syndrome, 7 (35 %) needed 
      reoperations. Patients with multiple endocrine neoplasia syndrome have a higher 
      risk of needing reoperation. Genetic testing can help identify MEN1 syndrome 
      preoperatively and to better evaluate the approach to surgery.
FAU - Libansky, P
AU  - Libansky P
AD  - 3rd Department of Surgery, 1st Faculty of Medicine, Charles University in Prague 
      and Motol University Hospital, Prague, Czech Republic. petr.libansky@lf1.cuni.cz.
FAU - Carkova, J
AU  - Carkova J
FAU - Kushnir, I
AU  - Kushnir I
FAU - Matejkova Behanova, M
AU  - Matejkova Behanova M
FAU - Procyklova, K
AU  - Procyklova K
FAU - Sedy, J
AU  - Sedy J
FAU - Vaculova, M
AU  - Vaculova M
FAU - Vcelak, J
AU  - Vcelak J
FAU - Zikan, V
AU  - Zikan V
FAU - Adamek, S
AU  - Adamek S
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
SB  - IM
MH  - Humans
MH  - *Multiple Endocrine Neoplasia Type 1/complications/diagnosis/genetics
MH  - *Hyperparathyroidism, Primary/diagnosis/genetics/surgery
MH  - Retrospective Studies
PMC - PMC10830164
COIS- Conflict of Interest: There is no conflict of interest.
EDAT- 2023/12/20 12:42
MHDA- 2023/12/21 06:43
PMCR- 2023/12/31
CRDT- 2023/12/20 07:46
PHST- 2023/12/21 06:43 [medline]
PHST- 2023/12/20 12:42 [pubmed]
PHST- 2023/12/20 07:46 [entrez]
PHST- 2023/12/31 00:00 [pmc-release]
AID - 935223 [pii]
AID - pr72_s423 [pii]
AID - 10.33549/physiolres.935223 [doi]
PST - ppublish
SO  - Physiol Res. 2023 Dec 17;72(S4):S423-S427. doi: 10.33549/physiolres.935223.