PMID- 38118331
OWN - NLM
STAT- MEDLINE
DCOM- 20240123
LR  - 20240202
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 270
DP  - 2024 Jan 15
TI  - Associations of urinary metal concentrations with anemia: A cross-sectional study 
      of Chinese community-dwelling elderly.
PG  - 115828
LID - S0147-6513(23)01332-5 [pii]
LID - 10.1016/j.ecoenv.2023.115828 [doi]
AB  - BACKGROUND: Anemia seriously affects the health and quality of life of the older 
      adult population and may be influenced by various types of environmental metal 
      exposure. Current studies on metals and anemia are mainly limited to single 
      metals, and the association between polymetals and their mixtures and anemia 
      remains unclear. METHODS: We determined 11 urinary metal concentrations and 
      hemoglobin levels in 3781 participants. Binary logistic regression and restricted 
      cubic spline (RCS) model were used to estimate the association of individual 
      metals with anemia. We used Bayesian kernel machine regression (BKMR) and 
      Quantile g-computation (Q-g) regression to assess the overall association between 
      metal mixtures and anemia and identify the major contributing elements. 
      Stratified analyses were used to explore the association of different metals with 
      anemia in different populations. RESULTS: In a single-metal model, nine urinary 
      metals significantly associated with anemia. RCS analysis further showed that the 
      association of arsenic (As) and copper (Cu) with anemia was linear, while cobalt, 
      molybdenum, thallium, and zinc were non-linear. The BKMR model revealed a 
      significant positive association between the concentration of metal mixtures and 
      anemia. Combined Q-g regression analysis suggested that metals such as Cu, As, 
      and tellurium (Te) were positively associated with anemia, with Te as the most 
      significant contributor. Stratified analyses showed that the association of 
      different metals with anemia varied among people of different sexes, obesity 
      levels, lifestyle habits, and blood pressure levels. CONCLUSIONS: Multiple metals 
      are associated with anemia in the older adult population. A significant positive 
      association was observed between metal mixture concentrations and anemia, with Te 
      being the most important factor. The association between urinary metal 
      concentrations and anemia is more sensitive in the non-hypertensive populations.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Qiao, Guojie
AU  - Qiao G
AD  - Radioimmunity Center, Shaanxi Provincial People's Hospital, Xi'an, 710069, 
      Shaanxi, P.R. China. Electronic address: qgj2016@hainanu.edu.cn.
FAU - Shen, Zhuoheng
AU  - Shen Z
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Duan, Siyu
AU  - Duan S
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Wang, Rui
AU  - Wang R
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - He, Pei
AU  - He P
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Zhang, Zhongyuan
AU  - Zhang Z
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Dai, Yuqing
AU  - Dai Y
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Li, Meiyan
AU  - Li M
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Chen, Yue
AU  - Chen Y
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Li, Xiaoyu
AU  - Li X
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Zhao, Yi
AU  - Zhao Y
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Liu, Zhihong
AU  - Liu Z
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Yang, Huifang
AU  - Yang H
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China; Ningxia Key Laboratory of Cerebrocranial 
      Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, 
      Yinchuan, 750004, Ningxia, P.R. China.
FAU - Guan, Suzhen
AU  - Guan S
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China. Electronic address: 
      guansz_nx2017@sina.com.
FAU - Sun, Jian
AU  - Sun J
AD  - School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan, 750004, Ningxia, P.R. China. Electronic address: 20180016@nxmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231220
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Metals)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Humans
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - Independent Living
MH  - Quality of Life
MH  - Metals/urine
MH  - *Arsenic/urine
MH  - *Anemia/epidemiology
MH  - China/epidemiology
OTO - NOTNLM
OT  - Anemia
OT  - Cross-sectional study
OT  - Metal mixture
OT  - Older people
OT  - Urinary metals
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/21 00:41
MHDA- 2024/01/23 06:42
CRDT- 2023/12/20 18:09
PHST- 2023/09/14 00:00 [received]
PHST- 2023/12/10 00:00 [revised]
PHST- 2023/12/11 00:00 [accepted]
PHST- 2024/01/23 06:42 [medline]
PHST- 2023/12/21 00:41 [pubmed]
PHST- 2023/12/20 18:09 [entrez]
AID - S0147-6513(23)01332-5 [pii]
AID - 10.1016/j.ecoenv.2023.115828 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2024 Jan 15;270:115828. doi: 
      10.1016/j.ecoenv.2023.115828. Epub 2023 Dec 20.