PMID- 38123769
OWN - NLM
STAT- MEDLINE
DCOM- 20240122
LR  - 20240202
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 31
IP  - 4
DP  - 2024 Jan
TI  - Association between combined exposure to dioxins and arthritis among US adults: a 
      cross-sectional study.
PG  - 5415-5428
LID - 10.1007/s11356-023-31423-6 [doi]
AB  - Dioxins and dioxin-like compounds (DLCs) are common pollutants hazardous to human 
      health. We applied 12 dioxins and DLCs data of 1851 participants (including 484 
      arthritis patients) from National Health Examination Survey (NHANES) 2001-2004 
      and quadrupled them into rank variables. Multivariate logistic regression, 
      weighted quantile sum (WQS) regression, and Bayesian kernel machine regression 
      (BKMR) models were used to explore the relationship between individual or mixed 
      exposure to the pollutants and arthritis after adjusting for multiple covariates. 
      In multivariable logistic regression with an individual dioxin or DLC, almost 
      every chemical was significantly positively associated with arthritis, except 
      PCB66 (polychlorinated biphenyl 66) and 1,2,3,4,6,7,8-heptachlorodibenzofuran 
      (hpcdf). The WQS model indicated that the combined exposure to the 12 dioxins and 
      DLCs was positively linked to arthritis (OR: 1.884, 95% CI: 1.514-2.346), with 
      PCB156 (weighted 0.281) making the greatest contribution. A positive trend 
      between combined exposure and arthritis was observed in the BKMR model, with a 
      posterior inclusion probability (PIP) of 0.987 for PCB156, which was also higher 
      than the other contaminants.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Meng, Qi
AU  - Meng Q
AD  - Department of Joint Surgery, Shandong Provincial Hospital, Shandong University, 
      Jinan, 250012, Shandong, China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, 250021, Shandong, China.
AD  - Orthopaedic Research Laboratory, Medical Science and Technology Innovation 
      Center, Shandong First Medical University & Shandong Academy of Medical Sciences, 
      Jinan, 250117, Shandong, China.
FAU - Yuan, Tao
AU  - Yuan T
AD  - Department of Joint Surgery, Shandong Provincial Hospital, Shandong University, 
      Jinan, 250012, Shandong, China.
FAU - Su, Yang
AU  - Su Y
AD  - Department of Joint Surgery, Shandong Provincial Hospital, Shandong University, 
      Jinan, 250012, Shandong, China.
FAU - Ge, Jianxun
AU  - Ge J
AD  - Department of Joint Surgery, Shandong Provincial Hospital, Shandong University, 
      Jinan, 250012, Shandong, China.
FAU - Dong, Shankun
AU  - Dong S
AD  - Department of Joint Surgery, Shandong Provincial Hospital, Shandong University, 
      Jinan, 250012, Shandong, China.
FAU - Sun, Shui
AU  - Sun S
AD  - Department of Joint Surgery, Shandong Provincial Hospital, Shandong University, 
      Jinan, 250012, Shandong, China. sunshui@sdfmu.edu.cn.
AD  - Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, 250021, Shandong, China. sunshui@sdfmu.edu.cn.
AD  - Orthopaedic Research Laboratory, Medical Science and Technology Innovation 
      Center, Shandong First Medical University & Shandong Academy of Medical Sciences, 
      Jinan, 250117, Shandong, China. sunshui@sdfmu.edu.cn.
LA  - eng
GR  - 82272485/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20231220
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Dioxins
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - Nutrition Surveys
MH  - *Environmental Pollutants
OTO - NOTNLM
OT  - Arthritis
OT  - Bayesian kernel machine regression
OT  - Dioxin
OT  - Dioxin-like compounds
OT  - Environmental exposure
OT  - Weighted quantile sum
EDAT- 2023/12/21 00:41
MHDA- 2024/01/22 06:43
CRDT- 2023/12/20 23:41
PHST- 2023/07/06 00:00 [received]
PHST- 2023/12/04 00:00 [accepted]
PHST- 2024/01/22 06:43 [medline]
PHST- 2023/12/21 00:41 [pubmed]
PHST- 2023/12/20 23:41 [entrez]
AID - 10.1007/s11356-023-31423-6 [pii]
AID - 10.1007/s11356-023-31423-6 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2024 Jan;31(4):5415-5428. doi: 
      10.1007/s11356-023-31423-6. Epub 2023 Dec 20.