PMID- 38124771
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231222
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Print)
IS  - 2049-9434 (Linking)
VI  - 20
IP  - 1
DP  - 2024 Jan
TI  - Protein expression analysis for predicting recurrent laryngeal squamous cell 
      carcinoma.
PG  - 15
LID - 10.3892/br.2023.1702 [doi]
LID - 15
AB  - The expression of a number of proteins plays a major role in predicting recurrent 
      laryngeal squamous cell carcinoma (LSCC). Thus, the aim of the present study was 
      to investigate the expression of 16 selected proteins as prognostic indicators 
      for recurrent and non-recurrent LSCC. Samples from a total of 41 patients with 
      LSCC were investigated by immunohistochemistry. Digital image analysis was 
      performed, and various associated factors were calculated. Histoscore (H-score) 
      and receiver operating characteristic curves were used to divide protein 
      expression in high and low for predicting disease recurrence. Disease-free 
      survival (DFS) curves, crude hazard ratios (HRs) and adjusted HRs were analyzed 
      and compared. Significantly different H-scores were found between the recurrent 
      and non-recurrent groups in terms of pRb and c-Met expression. pRb was expressed 
      at high levels in recurrent LSCC, while c-Met was expressed at low levels. 
      Patients with low pRb expression had a longer DFS than those with high pRb 
      expression (log-rank chi(2), 5.161; P=0.023). Patients with high c-Met expression 
      had a longer DFS than those with low c-Met expression (log-rank chi(2), 6.441; 
      P=0.011). Moreover, patients with high pRb expression and low c-Met expression 
      had the shortest DFS (log-rank chi(2), 11.827; P=0.008). Differentiated 
      histological factors had an impact on the risk of recurrence (Cox regression 
      test; crude HR, 9.53; 95% confidence interval, 1.214-74.819; P=0.032). The 
      present study demonstrated that the grading of differentiated squamous cell 
      carcinoma, pRb and c-Met expression are the most useful prognostic factors for 
      the prediction of recurrent LSCC. These might be further applied as potential 
      markers for clinical use.
CI  - Copyright: (c) Thanasan et al.
FAU - Thanasan, Siwaporn
AU  - Thanasan S
AD  - Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 
      10330, Thailand.
FAU - Ruangritchankul, Komkrit
AU  - Ruangritchankul K
AD  - Special Task Force for Activating Research, Department of Pathology, Faculty of 
      Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
FAU - Kitkumthorn, Nakarin
AU  - Kitkumthorn N
AD  - Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok 
      10400, Thailand.
FAU - Keelawat, Somboon
AU  - Keelawat S
AD  - Special Task Force for Activating Research, Department of Pathology, Faculty of 
      Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
FAU - Mahattanasakul, Patnarin
AU  - Mahattanasakul P
AD  - Department of Otolaryngology, Head and Neck Surgery, King Chulalongkorn Memorial 
      Hospital, Thai Red Cross Society, Faculty of Medicine, Chulalongkorn University, 
      Bangkok 10330, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20231201
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC10731163
OTO - NOTNLM
OT  - c-Met
OT  - immunohistochemistry
OT  - laryngeal squamous cell carcinoma
OT  - pRb
OT  - prognostic indicator
COIS- The authors declare that they have no competing interests.
EDAT- 2023/12/21 06:42
MHDA- 2023/12/21 06:43
PMCR- 2023/12/01
CRDT- 2023/12/21 04:02
PHST- 2023/10/05 00:00 [received]
PHST- 2023/11/13 00:00 [accepted]
PHST- 2023/12/21 06:43 [medline]
PHST- 2023/12/21 06:42 [pubmed]
PHST- 2023/12/21 04:02 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - BR-20-1-01702 [pii]
AID - 10.3892/br.2023.1702 [doi]
PST - epublish
SO  - Biomed Rep. 2023 Dec 1;20(1):15. doi: 10.3892/br.2023.1702. eCollection 2024 Jan.