PMID- 38125730
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231222
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 10
DP  - 2023
TI  - Combined exposure to multiple essential elements and cadmium at early pregnancy 
      on gestational diabetes mellitus: a prospective cohort study.
PG  - 1278617
LID - 10.3389/fnut.2023.1278617 [doi]
LID - 1278617
AB  - BACKGROUND: Minerals and trace elements were involved in the pathogenesis and 
      progression of diabetes. However, the association of mixed exposure to essential 
      elements and toxic elements with gestational diabetes mellitus (GDM) is poorly 
      understood. OBJECTIVE: This study aims to examine the associations between serum 
      calcium (Ca), iron (Fe), zinc (Zn), copper (Cu), magnesium (Mg), and cadmium (Cd) 
      concentrations in early pregnancy and GDM risk in Chinese pregnant women. METHOD: 
      A total of 1,168 pregnant women were included in this prospective cohort study. 
      The concentrations of serum elements were measured using the polarography method 
      before 14 gestational weeks and an oral glucose tolerance test was conducted at 
      24-28 gestational weeks to diagnose GDM. Binary logistic regression analysis and 
      restricted cubic spline were applied to evaluate the association between serum 
      individual element and GDM. Bayesian kernel machine regression (BKMR) and 
      weighted quantile sum (WQS) regression were used to assess the associations 
      between mixed essential elements and Cd exposure and GDM risk. RESULTS: The mean 
      concentrations of Zn (124.65 vs. 120.12 mumol/L), Fe (135.26 vs. 132.21 mumol/L) 
      and Cu (23.33 vs. 23.03 mumol/L) in the GDM group were significantly higher than 
      those in the control group. Single-element modeling results suggested that second 
      and fourth-quartile maternal Zn and Fe concentration, third and fourth-quartile 
      Cu concentration and fourth-quartile Ca concentration were associated with an 
      increased risk of GDM compared to first-quartile values. Restricted cubic spline 
      analysis showed U-shaped and non-linear relationships between Cd and GDM. 
      According to the BKMR models and WQS analyses, a six-element mixture was 
      significantly and positively associated with the risk of GDM. Additionally, Cd, 
      Zn, and Cu contributed the most strongly to the association. CONCLUSION: Serum 
      Zn, Cu, Fe, and Ca exposure during early pregnancy showed a positive association 
      with GDM in the individual evaluation. The multiple-evaluation showed that high 
      levels of elements mixture, particularly Cd, Zn, and Cu, may promote the 
      development of GDM.
CI  - Copyright (c) 2023 Deng, Chen, Liu, Zhou, Lin, Wei, Sun, Zhang and Huang.
FAU - Deng, Guifang
AU  - Deng G
AD  - Department of Clinical Nutrition, Union Shenzhen Hospital of Huazhong University 
      of Science and Technology, Shenzhen, China.
FAU - Chen, Hengying
AU  - Chen H
AD  - Department of Maternal and Child Health, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Liu, Yao
AU  - Liu Y
AD  - Department of Clinical Nutrition, Union Shenzhen Hospital of Huazhong University 
      of Science and Technology, Shenzhen, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, 
      China.
FAU - Zhou, Yingyu
AU  - Zhou Y
AD  - Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of 
      Tropical Disease Research, School of Public Health, Southern Medical University, 
      Guangzhou, China.
FAU - Lin, Xiaoping
AU  - Lin X
AD  - Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of 
      Tropical Disease Research, School of Public Health, Southern Medical University, 
      Guangzhou, China.
FAU - Wei, Yuanhuan
AU  - Wei Y
AD  - Department of Clinical Nutrition, Union Shenzhen Hospital of Huazhong University 
      of Science and Technology, Shenzhen, China.
FAU - Sun, Ruifang
AU  - Sun R
AD  - Department of Clinical Nutrition, Union Shenzhen Hospital of Huazhong University 
      of Science and Technology, Shenzhen, China.
FAU - Zhang, Zheqing
AU  - Zhang Z
AD  - Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of 
      Tropical Disease Research, School of Public Health, Southern Medical University, 
      Guangzhou, China.
FAU - Huang, Zhenhe
AU  - Huang Z
AD  - Geriatric Medicine Department, Union Shenzhen Hospital of Huazhong University of 
      Science and Technology, Shenzhen, China.
LA  - eng
PT  - Journal Article
DEP - 20231206
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC10730676
OTO - NOTNLM
OT  - cadmium
OT  - copper
OT  - elements
OT  - gestational diabetes mellitus
OT  - mixed exposure
OT  - zinc
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/12/21 06:42
MHDA- 2023/12/21 06:43
PMCR- 2023/01/01
CRDT- 2023/12/21 04:17
PHST- 2023/08/16 00:00 [received]
PHST- 2023/11/20 00:00 [accepted]
PHST- 2023/12/21 06:43 [medline]
PHST- 2023/12/21 06:42 [pubmed]
PHST- 2023/12/21 04:17 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2023.1278617 [doi]
PST - epublish
SO  - Front Nutr. 2023 Dec 6;10:1278617. doi: 10.3389/fnut.2023.1278617. eCollection 
      2023.