PMID- 38128176
OWN - NLM
STAT- MEDLINE
DCOM- 20240112
LR  - 20240112
IS  - 1532-866X (Electronic)
IS  - 0049-0172 (Linking)
VI  - 64
DP  - 2024 Feb
TI  - Clinical association of health-related quality of life and mortality in an 
      antineutrophil cytoplasmic antibody-associated vasculitis cohort.
PG  - 152353
LID - S0049-0172(23)00195-6 [pii]
LID - 10.1016/j.semarthrit.2023.152353 [doi]
AB  - OBJECTIVES: To evaluate the association between health-related quality of life 
      (HRQoL) and mortality in patients with antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV). METHODS: We searched patients with AAV 
      assessed for HRQoL at initial diagnosis using Short Form 36 (SF-36). 
      Relationships between SF-36 physical component summary (PCS) and mental component 
      summary (MCS) scales and variables were estimated using Pearson's correlation 
      analysis. Contal's and O'Quigley's methods were used to determine optimal SF-36 
      PCS cut-off for predicting all-cause mortality. The Cox proportional hazards 
      model and inverse probability of treatment weighting (IPTW) analysis were used to 
      ascertain prognostic implications of SF-36 scales and mortality. RESULTS: The 
      median SF-36 PCS and MCS values of the 189 patients were 47.5 and 53.3, 
      respectively, and 21 (11.1%) patients (microscopic polyangiitis [MPA], n=15; 
      granulomatosis with polyangiitis [GPA], n=6) died during follow-up. SF-36 PCS was 
      significantly but weakly associated with Birmingham Vasculitis Activity Score, 
      Five-factor score, erythrocyte sedimentation rate (ESR), and C-reactive protein. 
      However, SF-36 MCS was not associated with ESR. In the multivariable Cox 
      analysis, a decrease of SF-36 PCS score by one unit indicated a higher death risk 
      (hazard ratio [HR]: 1.030; 95% confidence interval [CI]: 1.007, 1.052; p=0.041), 
      which was not for SF-36 MCS. IPTW analysis in a subgroup of MPA and GPA patients 
      revealed increased patient mortality with SF-36 PCS <53.75 independently (HR: 
      3.249; 95% CI: 1.169, 9.033; p=0.024). CONCLUSION: Poor baseline physical 
      functioning associated with premature death in patients with MPA and GPA. HRQoL 
      assessment during initial diagnosis may provide clinical insights for this 
      population.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Ahn, Sung Soo
AU  - Ahn SS
AD  - Department of Internal Medicine, Yongin Severance Hospital, Yonsei University 
      College of Medicine, Yongin, Republic of Korea.
FAU - Heo, Seok-Jae
AU  - Heo SJ
AD  - Division of Biostatistics, Department of Biomedical Systems Informatics, Yonsei 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Ha, Jang Woo
AU  - Ha JW
AD  - Department of Internal Medicine, Yongin Severance Hospital, Yonsei University 
      College of Medicine, Yongin, Republic of Korea.
FAU - Park, Yong-Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea; Institute for Immunology and 
      Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of 
      Korea.
FAU - Lee, Sang-Won
AU  - Lee SW
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Republic of Korea; Institute for Immunology and 
      Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of 
      Korea. Electronic address: sangwonlee@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20231216
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Humans
MH  - *Granulomatosis with Polyangiitis/diagnosis
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Quality of Life
MH  - *Microscopic Polyangiitis
MH  - Prognosis
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis
OTO - NOTNLM
OT  - Health-related quality of life
OT  - SF-36
OT  - antineutrophil cytoplasmic antibody
OT  - mortality
OT  - vasculitis
COIS- Declaration of Competing Interest The authors declare that no competing interests 
      exist.
EDAT- 2023/12/22 00:42
MHDA- 2024/01/12 06:42
CRDT- 2023/12/21 18:00
PHST- 2023/08/14 00:00 [received]
PHST- 2023/10/27 00:00 [revised]
PHST- 2023/12/13 00:00 [accepted]
PHST- 2024/01/12 06:42 [medline]
PHST- 2023/12/22 00:42 [pubmed]
PHST- 2023/12/21 18:00 [entrez]
AID - S0049-0172(23)00195-6 [pii]
AID - 10.1016/j.semarthrit.2023.152353 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 2024 Feb;64:152353. doi: 10.1016/j.semarthrit.2023.152353. 
      Epub 2023 Dec 16.