PMID- 38128312
OWN - NLM
STAT- MEDLINE
DCOM- 20240123
LR  - 20240202
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 270
DP  - 2024 Jan 15
TI  - Associations between plasma metal/metalloid mixtures and the risk of central 
      obesity: A prospective cohort study of Chinese adults.
PG  - 115838
LID - S0147-6513(23)01342-8 [pii]
LID - 10.1016/j.ecoenv.2023.115838 [doi]
AB  - Central obesity has increased rapidly over the past decade and posed a 
      substantial disease burden worldwide. Exposure to metals/metalloids has been 
      acknowledged to be involved in the development of central obesity through 
      regulation of cortisol, insulin resistance, and glucocorticoid receptor 
      reduction. Despite the importance, it is lack of prospective study which 
      comprehensively evaluate the relations between multiple metals exposure and 
      central obesity. We explored the prospective associations of plasma metal 
      concentrations with central obesity in a prospective study of the Dongfeng-Tongji 
      cohort. The present study included 2127 participants with a 6.87-year mean 
      follow-up duration. We measured 23 plasma metal/metalloid concentrations at 
      baseline. The associations between metals and incident central obesity were 
      examined utilizing the Cox proportional hazard regression in single and multiple 
      metals models. Additionally, we applied elastic net (ENET), Bayesian kernel 
      machine regression (BKMR), plasma metal score (PMS), and quantile-based 
      g-computation (Qgcomp) models to explore the joint associations of metal mixtures 
      with central obesity. After adjusting potential confounders, we found significant 
      associations of plasma manganese (Mn) and thallium (Tl) concentrations with a 
      higher risk of central obesity, whereas plasma rubidium (Rb) concentration was 
      associated with a lower risk of central obesity both in single and multiple 
      metals models (all FDR <0.05). The ENET and Qqcomp models verified similar metals 
      (Mn, Rb, and Tl) as important predictors for central obesity. The results of both 
      BKMR model and PMS suggested cumulative exposure to metal mixtures was associated 
      with a higher risk of central obesity. Our findings suggested that co-exposure to 
      metals was associated with a higher risk of central obesity. This study expands 
      our knowledge that the management of metals/metalloids exposure may be beneficial 
      for the prevention of new-onset central obesity, which may subsequently alleviate 
      the disease burden of late-life health outcomes.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Zhang, Zirui
AU  - Zhang Z
AD  - Department of Occupational and Environmental Health, Key Laboratory of 
      Environment and Health, Ministry of Education and State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Xiao, Yang
AU  - Xiao Y
AD  - Department of Occupational and Environmental Health, Key Laboratory of 
      Environment and Health, Ministry of Education and State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Long, Pinpin
AU  - Long P
AD  - Department of Occupational and Environmental Health, Key Laboratory of 
      Environment and Health, Ministry of Education and State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Yu, Yanqiu
AU  - Yu Y
AD  - Department of Occupational and Environmental Health, Key Laboratory of 
      Environment and Health, Ministry of Education and State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Liu, Yiyi
AU  - Liu Y
AD  - Department of Occupational and Environmental Health, Key Laboratory of 
      Environment and Health, Ministry of Education and State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Liu, Kang
AU  - Liu K
AD  - Department of Occupational and Environmental Health, Key Laboratory of 
      Environment and Health, Ministry of Education and State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Yang, Handong
AU  - Yang H
AD  - Department of Cardiovascular Diseases, Dongfeng Central Hospital, Hubei 
      University of Medicine, Shiyan, China.
FAU - Li, Xiulou
AU  - Li X
AD  - Department of Cardiovascular Diseases, Dongfeng Central Hospital, Hubei 
      University of Medicine, Shiyan, China.
FAU - He, Meian
AU  - He M
AD  - Department of Occupational and Environmental Health, Key Laboratory of 
      Environment and Health, Ministry of Education and State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Wu, Tangchun
AU  - Wu T
AD  - Department of Occupational and Environmental Health, Key Laboratory of 
      Environment and Health, Ministry of Education and State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Yuan, Yu
AU  - Yuan Y
AD  - Department of Occupational and Environmental Health, Key Laboratory of 
      Environment and Health, Ministry of Education and State Key Laboratory of 
      Environmental Health (Incubating), School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China. Electronic 
      address: yuyuan8hust@163.com.
LA  - eng
PT  - Journal Article
DEP - 20231220
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Metals)
RN  - 42Z2K6ZL8P (Manganese)
RN  - 0 (Metalloids)
RN  - AD84R52XLF (Thallium)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Prospective Studies
MH  - *Obesity, Abdominal/epidemiology
MH  - Bayes Theorem
MH  - Metals
MH  - Manganese
MH  - Obesity/epidemiology
MH  - *Metalloids
MH  - Thallium
MH  - China/epidemiology
OTO - NOTNLM
OT  - Central obesity
OT  - Joint association
OT  - Plasma multiple metals
OT  - Prospective study
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/22 00:42
MHDA- 2024/01/23 06:43
CRDT- 2023/12/21 18:08
PHST- 2023/09/19 00:00 [received]
PHST- 2023/12/07 00:00 [revised]
PHST- 2023/12/13 00:00 [accepted]
PHST- 2024/01/23 06:43 [medline]
PHST- 2023/12/22 00:42 [pubmed]
PHST- 2023/12/21 18:08 [entrez]
AID - S0147-6513(23)01342-8 [pii]
AID - 10.1016/j.ecoenv.2023.115838 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2024 Jan 15;270:115838. doi: 
      10.1016/j.ecoenv.2023.115838. Epub 2023 Dec 20.