PMID- 38129100
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240106
IS  - 2713-4148 (Electronic)
IS  - 2713-4148 (Linking)
VI  - 67
IP  - 1
DP  - 2024 Jan
TI  - Relationship between inflammatory biomarkers and insulin resistance in 
      excess-weight Latin children.
PG  - 37-45
LID - 10.3345/cep.2022.01382 [doi]
AB  - BACKGROUND: Excess weight, inflammation, and insulin resistance (IR) are 
      associated, but the prevalence of and biomarkers for IR in Latin children are 
      unknown. PURPOSE: This study aimed to determine the prevalence of IR in 
      prepubertal and pubertal Latin children with excess weight and explore the 
      usefulness of different biomarkers of low-grade inflammation for identifying IR 
      status. METHODS: Sixty-eight children (31 boys, 37 girls; approximately 11 years 
      of age) with excess weight (overweight and obese) and 20 healthy normal-weight 
      children (12 boys, 8 girls; approximately 12 years of age) were included. 
      Anthropometric parameters, insulin, neutrophil/lymphocyte ratio, 
      platelet/lymphocyte ratio, tumor necrosis factor- alpha (TNF-alpha), interleukin (IL)-6, 
      monocyte chemoattractant protein-1 (MCP-1), soluble CD40 ligand (sCD40L), 
      high-sensitivity C-reactive protein (hs-CRP), and myeloperoxidase were assessed 
      and IR was determined by homeostasis model assessment index (cutoff points: 2.67 
      and 2.22 in prepubertal boys and girls and 5.55 and 3.82 in pubertal boys and 
      girls, respectively). Intergroup differences were compared, correlations were 
      investigated using Pearson correlation coefficient, and stepwise multiple linear 
      regression analyses were performed to estimate the relationship between 
      inflammatory biomarkers and IR. RESULTS: The prevalence of IR among overweight 
      children was 62%. IL-6 levels differed between overweight and obese boys, while 
      erythrocyte sedimentation rate, MCP-1, TNF-alpha, IL-6, hs-CRP, and sCD40L differed 
      between obese and normal-weight boys. In contrast, sCD40L levels were increased 
      in overweight versus normal-weight girls, while MCP-1, TNF-alpha, IL-6, and sCD40L 
      differed between obese and normal-weight girls. Furthermore, MCP-1 and sCD40L 
      levels and erythrocyte sedimentation rate were positively correlated with IR; 
      however, a stepwise regression analysis that adjusted for the body mass index 
      (BMI) z score, sex, and age showed that none were good predictors of IR status. 
      CONCLUSION: The prevalence of IR is high among Latin children with excess weight. 
      Although some inflammatory biomarkers differed among groups, none robustly 
      predicted IR.
FAU - Aleman, Mariano Nicolas
AU  - Aleman MN
AD  - Departamento de Bioquimica Aplicada, Facultad de Bioquimica, Quimicay Farmacia, 
      Universidad Nacional de Tucuman, San Miguel de Tucuman, Argentina.
FAU - Luciardi, Maria Constanza
AU  - Luciardi MC
AD  - Departamento de Bioquimica Aplicada, Facultad de Bioquimica, Quimicay Farmacia, 
      Universidad Nacional de Tucuman, San Miguel de Tucuman, Argentina.
FAU - Albornoz, Emilce Romina
AU  - Albornoz ER
AD  - Departamento de Bioquimica Aplicada, Facultad de Bioquimica, Quimicay Farmacia, 
      Universidad Nacional de Tucuman, San Miguel de Tucuman, Argentina.
FAU - Bazan, Maria Cristina
AU  - Bazan MC
AD  - Departamento de Endocrinologia, Hospital del Nino Jesus de Tucuman, San Miguel de 
      Tucuman, Argentina.
FAU - Abregu, Adela Victoria
AU  - Abregu AV
AD  - Departamento de Bioquimica Aplicada, Facultad de Bioquimica, Quimicay Farmacia, 
      Universidad Nacional de Tucuman, San Miguel de Tucuman, Argentina.
LA  - eng
PT  - Journal Article
DEP - 20231221
PL  - Korea (South)
TA  - Clin Exp Pediatr
JT  - Clinical and experimental pediatrics
JID - 101761234
PMC - PMC10764670
OTO - NOTNLM
OT  - Biomarkers
OT  - Child
OT  - Inflammation
OT  - Insulin resistance
OT  - Obesity
COIS- Conflicts of interest No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2023/12/22 00:42
MHDA- 2023/12/22 00:43
PMCR- 2023/12/21
CRDT- 2023/12/21 21:12
PHST- 2022/11/23 00:00 [received]
PHST- 2023/11/01 00:00 [accepted]
PHST- 2023/12/22 00:43 [medline]
PHST- 2023/12/22 00:42 [pubmed]
PHST- 2023/12/21 21:12 [entrez]
PHST- 2023/12/21 00:00 [pmc-release]
AID - cep.2022.01382 [pii]
AID - cep-2022-01382 [pii]
AID - 10.3345/cep.2022.01382 [doi]
PST - ppublish
SO  - Clin Exp Pediatr. 2024 Jan;67(1):37-45. doi: 10.3345/cep.2022.01382. Epub 2023 
      Dec 21.