PMID- 38129825 OWN - NLM STAT- MEDLINE DCOM- 20231225 LR - 20240117 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 23 IP - 1 DP - 2023 Dec 21 TI - Lymphadenectomy and optimal excise lymph nodes count for early-stage primary fallopian tube cancer: a SEER-based study. PG - 681 LID - 10.1186/s12905-023-02833-y [doi] LID - 681 AB - BACKGROUNDS: There is still no consensus on the significance of Lymphadenectomy (LD) and the number of lymph nodes that need to be excised (ELNs) for adequate LD in patients with early-stage primary fallopian tube cancer (PFTC). Our endeavor is geared towards deepening comprehension of LD in early-stage PFTC and identify the optimal cut-off of ELNs. METHODS: This SEER-based study analyzed the clinical data of patients with early-stage PFTC between 2000 and 2018. X-tile was employed to confirm the optimal cut-off of ELNs. The survival data between groups were analyzed by the Kaplan-Meier estimates, Log-rank test and Cox proportional hazards model. RESULTS: There was significant improvement in both mean cancer-specific survival (CSS, p < 0.001) and overall survival (OS, p < 0.001) in LD group. Regardless of matched or not, LD was identified as an independent protective factor of CSS and OS. The optimal 3-year CSS-based cutoff of ELNs was 11 (p = 0.026) as determined by X-tile. Both the mean CSS (p = 0.001) and mean OS (p = 0.002) in adequate LD group (ELNs > 11, n = 574) were significantly longer than these in inadequate LD group (ELNs 11 and an improved prognosis is evident. Future studies are needed to further clarify the results above. CI - (c) 2023. The Author(s). FAU - Liu, Yuexi AU - Liu Y AD - Department of Obstetrics and Gynecology, The first Affiliated Hospital of Chongqing Medical university, Chongqing, China. FAU - Huang, Fanfan AU - Huang F AD - Department of Ophthalmology, The first Affiliated Hospital of Chongqing Medical university, Chongqing, China. FAU - Gu, Qiuying AU - Gu Q AD - Department of Obstetrics and Gynecology, The first Affiliated Hospital of Chongqing Medical university, Chongqing, China. FAU - Wang, Jinlong AU - Wang J AD - Department of Obstetrics and Gynecology, The first Affiliated Hospital of Chongqing Medical university, Chongqing, China. FAU - Wang, Qingmiao AU - Wang Q AD - Department of Obstetrics and Gynecology, The first Affiliated Hospital of Chongqing Medical university, Chongqing, China. FAU - Wu, Yuyang AU - Wu Y AD - Chongqing Medical university, Address No. 1, Medical College Road, Chongqing, Yuzhong District, 400016, China. FAU - Li, Lijuan AU - Li L AUID- ORCID: 0000-0002-3861-3035 AD - Department of Gynecologic Oncology, School of Medicine, the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. 18621823027@163.com. FAU - Xiao, Yao AU - Xiao Y AUID- ORCID: 0000-0001-9929-4843 AD - Chongqing Medical university, Address No. 1, Medical College Road, Chongqing, Yuzhong District, 400016, China. 435506910@qq.com. LA - eng PT - Journal Article DEP - 20231221 PL - England TA - BMC Womens Health JT - BMC women's health JID - 101088690 SB - IM MH - Female MH - Humans MH - *Fallopian Tube Neoplasms/surgery/pathology MH - Neoplasm Staging MH - Lymph Node Excision MH - Lymph Nodes/pathology MH - Prognosis PMC - PMC10740229 OTO - NOTNLM OT - Lymphadenectomy OT - Optimal excise lymph node count OT - Primary fallopian tube cancer OT - Prognosis OT - SEER database COIS- The authors declare no competing interests. EDAT- 2023/12/22 06:43 MHDA- 2023/12/25 06:41 PMCR- 2023/12/21 CRDT- 2023/12/22 00:21 PHST- 2023/07/31 00:00 [received] PHST- 2023/12/07 00:00 [accepted] PHST- 2023/12/25 06:41 [medline] PHST- 2023/12/22 06:43 [pubmed] PHST- 2023/12/22 00:21 [entrez] PHST- 2023/12/21 00:00 [pmc-release] AID - 10.1186/s12905-023-02833-y [pii] AID - 2833 [pii] AID - 10.1186/s12905-023-02833-y [doi] PST - epublish SO - BMC Womens Health. 2023 Dec 21;23(1):681. doi: 10.1186/s12905-023-02833-y.