PMID- 38129862 OWN - NLM STAT- MEDLINE DCOM- 20231225 LR - 20231225 IS - 1471-2466 (Electronic) IS - 1471-2466 (Linking) VI - 23 IP - 1 DP - 2023 Dec 21 TI - Exposure to air pollution concentrations of various intensities in early life and allergic sensitisation later in childhood. PG - 516 LID - 10.1186/s12890-023-02815-8 [doi] LID - 516 AB - BACKGROUND: Evidence on the relationship between air pollution and allergic sensitisation in childhood is inconsistent, and this relationship has not been investigated in the context of smoke events that are predicted to increase with climate change. Thus, we aimed to evaluate associations between exposure in two early life periods to severe levels of particulate matter with an aerodynamic diameter < 2.5 mum (PM(2.5)) from a mine fire, background PM(2.5), and allergic sensitisation later in childhood. METHODS: We measured specific immunoglobulin E (IgE) levels for seven common aeroallergens as well as total IgE levels in a cohort of children who had been exposed to the Hazelwood coal mine fire, either in utero or during their first two years of life, in a regional area of Australia where ambient levels of PM(2.5) are generally low. We estimated personal exposure to fire-specific emissions of PM(2.5) based on a high-resolution meteorological and pollutant dispersion model and detailed reported movements of pregnant mothers and young children during the fire. We also estimated the usual background exposure to PM(2.5) at the residential address at birth using a national satellite-based land-use regression model. Associations between both sources of PM(2.5) and sensitisation to dust, cat, fungi, and grass seven years after the fire were estimated with logistic regression, while associations with total IgE levels were estimated with linear regression. RESULTS: No association was found between the levels of exposure at either developmental stage to fire-related PM(2.5) and allergic sensitisation seven years after the event. However, levels of background exposure were positively associated with sensitisation to dust (OR = 1.90, 95%CI = 1.12,3.21 per 1 mug/m(3)). CONCLUSIONS: Chronic but low exposure to PM(2.5) in early life could be more strongly associated with allergic sensitisation in childhood than time-limited high exposure levels, such as the ones experienced during landscape fires. CI - (c) 2023. The Author(s). FAU - Ziou, Myriam AU - Ziou M AD - Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, 7000, Australia. Myriam.Ziou@utas.edu.au. FAU - Gao, Caroline X AU - Gao CX AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, 3004, Australia. AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, 3052, Australia. FAU - Wheeler, Amanda J AU - Wheeler AJ AD - Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, 7000, Australia. AD - Commonwealth Scientific and Industrial Research Organisation (CSIRO) Environment, Aspendale, Victoria, 3195, Australia. FAU - Zosky, Graeme R AU - Zosky GR AD - Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, 7000, Australia. AD - Tasmanian School of Medicine, University of Tasmania, Hobart, Tasmania, 7000, Australia. FAU - Stephens, Nicola AU - Stephens N AD - Tasmanian School of Medicine, University of Tasmania, Hobart, Tasmania, 7000, Australia. FAU - Knibbs, Luke D AU - Knibbs LD AD - School of Public Health, The University of Sydney, Camperdown, NSW, 2006, Australia. AD - Public Health Research Analytics and Methods for Evidence, Public Health Unit, Sydney Local Health District, Camperdown, NSW, 2050, Australia. FAU - Williamson, Grant J AU - Williamson GJ AD - School of Natural Sciences, University of Tasmania, Sandy Bay, Tasmania, 7005, Australia. FAU - Dalton, Marita F AU - Dalton MF AD - Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, 7000, Australia. FAU - Dharmage, Shyamali C AU - Dharmage SC AD - Allergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Carlton, Victoria, 3052, Australia. FAU - Johnston, Fay H AU - Johnston FH AD - Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, 7000, Australia. LA - eng PT - Journal Article DEP - 20231221 PL - England TA - BMC Pulm Med JT - BMC pulmonary medicine JID - 100968563 RN - 0 (Air Pollutants) RN - 0 (Particulate Matter) RN - 0 (Dust) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Infant, Newborn MH - Pregnancy MH - Child MH - Female MH - Humans MH - Child, Preschool MH - *Air Pollutants/analysis MH - *Air Pollution/adverse effects MH - Particulate Matter/analysis MH - *Immune System Diseases MH - Dust MH - Immunoglobulin E MH - Environmental Exposure/adverse effects PMC - PMC10740230 OTO - NOTNLM OT - Allergic sensitisation OT - Child health OT - Early life OT - Immunoglobulin E OT - Landscape fires OT - Long-term effects OT - Particulate air pollution COIS- No conflicts of interest to declare for the following authors: MZ, CG, AW, GZ, NS, LK, GW or MD. SD reports a relationship with AstraZeneca plc that includes: funding grants. SD reports a relationship with GSK plc that includes: funding grants. FJ reports financial support from the Victoria Department of Health. EDAT- 2023/12/22 06:43 MHDA- 2023/12/25 06:42 PMCR- 2023/12/21 CRDT- 2023/12/22 00:25 PHST- 2023/06/10 00:00 [received] PHST- 2023/12/13 00:00 [accepted] PHST- 2023/12/25 06:42 [medline] PHST- 2023/12/22 06:43 [pubmed] PHST- 2023/12/22 00:25 [entrez] PHST- 2023/12/21 00:00 [pmc-release] AID - 10.1186/s12890-023-02815-8 [pii] AID - 2815 [pii] AID - 10.1186/s12890-023-02815-8 [doi] PST - epublish SO - BMC Pulm Med. 2023 Dec 21;23(1):516. doi: 10.1186/s12890-023-02815-8.